Identification of RBMX as a splicing regulator in Parkinsonian mimetic induced alternative splicing of α-synuclein.
Alternative splicing
MPP(+)
Minigene
RBMX
α-Synuclein
Journal
Biochimica et biophysica acta. Gene regulatory mechanisms
ISSN: 1876-4320
Titre abrégé: Biochim Biophys Acta Gene Regul Mech
Pays: Netherlands
ID NLM: 101731723
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
03
12
2021
revised:
28
04
2022
accepted:
06
05
2022
pubmed:
17
5
2022
medline:
9
6
2022
entrez:
16
5
2022
Statut:
ppublish
Résumé
α-Synuclein (α-syn) plays a precipitating role in Parkinson's disease (PD) due to its tendency to form oligomers and fibrils. The presence of smaller isoforms of α-syn was widely noticed in the affected brain regions of PD patients. 112-synuclein (112-syn) which lacks exon-5, possess enhanced aggregation propensity and forms intracellular inclusions. However, the factors responsible for the skipping of exon-5 are not completely understood. In this context, we aimed to identity the cis & trans-acting elements governing alternative splicing (AS) events by the Parkinsonian agent (MPP
Identifiants
pubmed: 35577270
pii: S1874-9399(22)00040-2
doi: 10.1016/j.bbagrm.2022.194825
pii:
doi:
Substances chimiques
Heterogeneous-Nuclear Ribonucleoproteins
0
KHDRBS3 protein, human
0
Protein Isoforms
0
RBMX protein, human
0
RNA-Binding Proteins
0
alpha-Synuclein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
194825Informations de copyright
Copyright © 2022. Published by Elsevier B.V.