Longitudinal Trajectory of the Link Between Ventral Striatum and Depression in Adolescence.
Cohort
Depressive Disorders
Development
Neuroimaging
Journal
The American journal of psychiatry
ISSN: 1535-7228
Titre abrégé: Am J Psychiatry
Pays: United States
ID NLM: 0370512
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
pubmed:
19
5
2022
medline:
6
7
2022
entrez:
18
5
2022
Statut:
ppublish
Résumé
Research in adolescent depression has found aberrant intrinsic functional connectivity (iFC) among the ventral striatum (VS) and several brain regions implicated in reward processing. The present study probes this question by taking advantage of the availability of data from a large youth cohort, the IMAGEN Consortium. iFC data from 303 adolescents (48% of them female) were used to examine associations of VS connectivity at baseline (at age 14) with depressive disorders at baseline and at 2-year (N=250) and 4-year (N=219) follow-ups. Eleven regions of interest, key nodes of the reward system, were used to probe the reward network and calculate the connectivity strength of the VS within this network (VS connectivity Higher right VS connectivity The connectivity strength of the VS within the reward network showed distinct patterns of association with depressive disorders and anhedonia from mid to late adolescence, suggesting that the role of this circuitry in depression changes with age. This study replicates, in an independent sample, the association between the VS and depression previously reported in younger adolescents. The findings suggest a role of VS connectivity
Identifiants
pubmed: 35582783
doi: 10.1176/appi.ajp.20081180
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
470-481Subventions
Organisme : MRF
ID : MRF_MRF-058-0004-RG-DESRI
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R00465X/1
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG058854
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA049238
Pays : United States
Organisme : Medical Research Council
ID : MR/W002418/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S020306/1
Pays : United Kingdom
Organisme : Intramural NIH HHS
ID : ZIA MH002798
Pays : United States
Organisme : MRF
ID : MRF_MRF-058-0009-RG-DESR-C0759
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N000390/1
Pays : United Kingdom
Organisme : Intramural NIH HHS
ID : ZIA MH002957
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH085772
Pays : United States