The association of decreased HLA-G
COVID-19
HLA-G(+) T cells
HLA-G(+) monocytes
SARS-CoV-2
Journal
Microbial pathogenesis
ISSN: 1096-1208
Titre abrégé: Microb Pathog
Pays: England
ID NLM: 8606191
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
20
12
2021
revised:
09
04
2022
accepted:
19
04
2022
pubmed:
19
5
2022
medline:
7
6
2022
entrez:
18
5
2022
Statut:
ppublish
Résumé
COVID-19 (coronavirus disease-2019) is an infectious disease caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). Immune dysregulation causes inflammation and massive production of inflammatory mediators that worsen the patients' status. Here, regulatory immune cells may ameliorate inflammation and improve the severity of the disease. A total of 76 participants were enrolled in this study and divided into 3 groups as follows: patients with moderate/severe COVID-19 (n = 25), patients with critical COVID-19 (n = 26), and healthy controls (n = 25). After blood collection, peripheral blood mononuclear cells (PBMCs) were isolated and stained by FITC-conjugated anti-CD4 monoclonal antibodies (mABs), PE-conjugated anti-HLA-G mABs, PerCPCy5.5-conjugated anti-CD14 mABs, and APC-conjugated anti-CD8 mABs. Critical COVID-19 patients had a significantly lower frequency of CD4 The increased amount of immunomodulatory HLA-G
Identifiants
pubmed: 35584714
pii: S0882-4010(22)00163-2
doi: 10.1016/j.micpath.2022.105550
pmc: PMC9107627
pii:
doi:
Substances chimiques
HLA-G Antigens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105550Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
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