The association of decreased HLA-G


Journal

Microbial pathogenesis
ISSN: 1096-1208
Titre abrégé: Microb Pathog
Pays: England
ID NLM: 8606191

Informations de publication

Date de publication:
Jun 2022
Historique:
received: 20 12 2021
revised: 09 04 2022
accepted: 19 04 2022
pubmed: 19 5 2022
medline: 7 6 2022
entrez: 18 5 2022
Statut: ppublish

Résumé

COVID-19 (coronavirus disease-2019) is an infectious disease caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). Immune dysregulation causes inflammation and massive production of inflammatory mediators that worsen the patients' status. Here, regulatory immune cells may ameliorate inflammation and improve the severity of the disease. A total of 76 participants were enrolled in this study and divided into 3 groups as follows: patients with moderate/severe COVID-19 (n = 25), patients with critical COVID-19 (n = 26), and healthy controls (n = 25). After blood collection, peripheral blood mononuclear cells (PBMCs) were isolated and stained by FITC-conjugated anti-CD4 monoclonal antibodies (mABs), PE-conjugated anti-HLA-G mABs, PerCPCy5.5-conjugated anti-CD14 mABs, and APC-conjugated anti-CD8 mABs. Critical COVID-19 patients had a significantly lower frequency of CD4 The increased amount of immunomodulatory HLA-G

Identifiants

pubmed: 35584714
pii: S0882-4010(22)00163-2
doi: 10.1016/j.micpath.2022.105550
pmc: PMC9107627
pii:
doi:

Substances chimiques

HLA-G Antigens 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

105550

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

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Auteurs

Somayeh Ramzannezhad (S)

Immunoregulation Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Department of Pathology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

Mona Tarighi (M)

Immunoregulation Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Department of Immunology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

Mousa Mohammadnia-Afrouzi (M)

Immunoregulation Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Department of Immunology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

Soudabeh Aghapour (S)

Immunoregulation Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Department of Immunology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

Mojgan Bagherzadeh (M)

Immunoregulation Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Department of Immunology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

Zahra Ahmadnia (Z)

Department of Pathology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

Akramossadat Hosseini (A)

Department of Pathology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

Mostafa Javanian (M)

Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

Housein Ghorbani (H)

Immunoregulation Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Department of Pathology, School of Medicine, Babol University of Medical Sciences, Babol, Iran. Electronic address: Ghorbani7958@yahoo.com.

Mehdi Shahbazi (M)

Immunoregulation Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran; Department of Immunology, School of Medicine, Babol University of Medical Sciences, Babol, Iran. Electronic address: mehdishahbazi60@yahoo.com.

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Classifications MeSH