Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide.

Bumetanide / pharmacology Cations / metabolism Chlorides / metabolism Diuretics / pharmacology Solute Carrier Family 12, Member 2 Symporters

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
18 05 2022
Historique:
received: 08 11 2021
accepted: 28 04 2022
entrez: 18 5 2022
pubmed: 19 5 2022
medline: 21 5 2022
Statut: epublish

Résumé

Cation-chloride cotransporters (CCCs) NKCC1 and NKCC2 catalyze electroneutral symport of 1 Na

Identifiants

DOI: 10.1038/s41467-022-30407-3 PMID: 35585053 PMC: PMC9117670
pubmed: 35585053
doi: 10.1038/s41467-022-30407-3
pii: 10.1038/s41467-022-30407-3
pmc: PMC9117670
doi:

Substances chimiques

Cations 0
Chlorides 0
Diuretics 0
Solute Carrier Family 12, Member 2 0
Symporters 0
Bumetanide 0Y2S3XUQ5H

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2747

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK128592
Pays : United States
Organisme : NIGMS NIH HHS
ID : U24 GM129539
Pays : United States
Organisme : NIGMS NIH HHS
ID : U24 GM129547
Pays : United States

Informations de copyright

© 2022. The Author(s).

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Auteurs

Yongxiang Zhao (Y)

Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, 84112-5650, USA.

Kasturi Roy (K)

Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.
ORCID: 0000-0003-2504-3114

Pietro Vidossich (P)

Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genova, Italy.

Laura Cancedda (L)

Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genova, Italy.
ORCID: 0000-0003-0566-057X

Marco De Vivo (M)

Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genova, Italy.
ORCID: 0000-0003-4022-5661

Biff Forbush (B)

Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA. biff.forbush@yale.edu.
ORCID: 0000-0001-5250-4057

Erhu Cao (E)

Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, 84112-5650, USA. Erhu.Cao@biochem.utah.edu.
ORCID: 0000-0003-3102-5692

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Sulfonamides › Bumétanide › Structural basis for inhibition of the...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Cations › Structural basis for inhibition of the...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Anions › Chlorures › Structural basis for inhibition of the...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Diurétiques › Structural basis for inhibition of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Symporteurs des ions sodium-potassium-chlorure › Membre-2 de la famille-12 des transporteurs de solutés › Structural basis for inhibition of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Symporteurs › Structural basis for inhibition of the...