Recent developments in computational and experimental studies of physicochemical properties of Au and Ag nanostructures on cellular uptake and nanostructure toxicity.
Cellular uptake
Coordination chemistry
Gold (Au) nanostructures
Physicochemical properties
Silver (Ag)
Surface chemistry
Toxicity
Journal
Biochimica et biophysica acta. General subjects
ISSN: 1872-8006
Titre abrégé: Biochim Biophys Acta Gen Subj
Pays: Netherlands
ID NLM: 101731726
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
10
02
2022
revised:
06
05
2022
accepted:
11
05
2022
pubmed:
20
5
2022
medline:
3
6
2022
entrez:
19
5
2022
Statut:
ppublish
Résumé
Recent developments in studies of the uptake and toxicity of both gold (Au) and silver (Ag) nanostructures (NS) in drug delivery systems have shown that physicochemical properties play an important role. Physicochemical properties of engineered NS such as size, shape, coordination chemistry, surface charge, and surface chemistry generally manifest in reactivity, surface energetics and electronic properties of the nanomaterials. This review discusses the computational and experimental studies conducted to study the effects of physicochemical properties on cellular uptake and nanostructure toxicity. The studies show that properties like coordination chemistry have often been overlooked when studying the high surface energy of NS.
Identifiants
pubmed: 35588956
pii: S0304-4165(22)00088-5
doi: 10.1016/j.bbagen.2022.130170
pii:
doi:
Substances chimiques
Silver
3M4G523W1G
Gold
7440-57-5
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
130170Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.