Enzymatic continuous-flow preparation of nature-inspired phenolic esters as antiradical and antimicrobial agents.

Anti-Infective Agents / pharmacology Antioxidants Enzymes, Immobilized Esters Fungal Proteins Lipase Phenols
Antimicrobial agents Flow chemistry Food preservatives Lipase Phenolic esters Radical scavenger

Journal

Food chemistry
ISSN: 1873-7072
Titre abrégé: Food Chem
Pays: England
ID NLM: 7702639

Informations de publication

Date de publication:
01 Oct 2022
Historique:
received: 22 12 2021
revised: 30 04 2022
accepted: 08 05 2022
pubmed: 21 5 2022
medline: 7 6 2022
entrez: 20 5 2022
Statut: ppublish

Résumé

A collection of nature-inspired lipophilic phenolic esters have been prepared by an enzymatic synthesis under flow conditions, using the immobilized lipase B from Candida antarctica (Novozyme 435®) as a catalyst in cyclopentyl methyl ether (CPME), a non-conventional and green solvent. Their antimicrobial activity against four selected bacterial strains together with their efficiency as radical scavengers were evaluated. The obtained compounds were characterized by enhanced lipophilicity in comparison with the parent non-esterified compounds, which increased the possibility of their use as additives in the food industry.

Identifiants

DOI: 10.1016/j.foodchem.2022.133195 PMID: 35594770
pubmed: 35594770
pii: S0308-8146(22)01157-8
doi: 10.1016/j.foodchem.2022.133195
pii:
doi:

Substances chimiques

Anti-Infective Agents 0
Antioxidants 0
Enzymes, Immobilized 0
Esters 0
Fungal Proteins 0
Phenols 0
Lipase EC 3.1.1.3

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

133195

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Auteurs

Francesca Annunziata (F)

Department of Pharmaceutical Sciences (DISFARM), University of Milan, via Mangiagalli 25, 20133 Milan, Italy.

Martina L Contente (ML)

Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133 Milan, Italy.

Valentina Anzi (V)

Department of Pharmaceutical Sciences (DISFARM), University of Milan, via Mangiagalli 25, 20133 Milan, Italy.

Silvia Donzella (S)

Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133 Milan, Italy.

Paola Conti (P)

Department of Pharmaceutical Sciences (DISFARM), University of Milan, via Mangiagalli 25, 20133 Milan, Italy.

Francesco Molinari (F)

Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133 Milan, Italy.

Piera Anna Martino (PA)

Department of Biomedical, Surgical and Dental Sciences (DSBCO), One Health Unit, University of Milan, via Pascal 36, 20133 Milan, Italy.

Gabriele Meroni (G)

Department of Biomedical, Surgical and Dental Sciences (DSBCO), One Health Unit, University of Milan, via Pascal 36, 20133 Milan, Italy.

Valerio Massimo Sora (VM)

Department of Biomedical, Surgical and Dental Sciences (DSBCO), One Health Unit, University of Milan, via Pascal 36, 20133 Milan, Italy.

Lucia Tamborini (L)

Department of Pharmaceutical Sciences (DISFARM), University of Milan, via Mangiagalli 25, 20133 Milan, Italy. Electronic address: lucia.tamborini@unimi.it.

Andrea Pinto (A)

Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133 Milan, Italy.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Enzymatic continuous-flow preparation of...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Enzymatic continuous-flow preparation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines immobilisées › Enzymes immobilisées › Enzymatic continuous-flow preparation of...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Esters › Enzymatic continuous-flow preparation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Enzymatic continuous-flow preparation of...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Triacylglycerol lipase › Enzymatic continuous-flow preparation of...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Enzymatic continuous-flow preparation of...