Sex differences in efficacy of pharmacological therapies in heart failure with reduced ejection fraction: a meta-analysis.
Female
Humans
Male
Middle Aged
Adrenergic beta-Antagonists
/ pharmacology
Angiotensin Receptor Antagonists
/ pharmacology
Angiotensin-Converting Enzyme Inhibitors
/ therapeutic use
Heart Failure
/ therapy
Mineralocorticoid Receptor Antagonists
/ therapeutic use
Sex Characteristics
Sodium-Glucose Transporter 2 Inhibitors
/ pharmacology
Stroke Volume
/ physiology
Ventricular Function, Left
Guideline-directed medical therapy
Heart failure with reduced ejection fraction
Pharmacology
Sex differences
Journal
ESC heart failure
ISSN: 2055-5822
Titre abrégé: ESC Heart Fail
Pays: England
ID NLM: 101669191
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
revised:
24
03
2022
received:
28
12
2021
accepted:
08
05
2022
pubmed:
24
5
2022
medline:
20
7
2022
entrez:
23
5
2022
Statut:
ppublish
Résumé
Recent studies have suggested potential sex differences in treatment response to pharmacological therapies in heart failure (HF). We performed a systematic review and meta-analysis of studies comparing treatment effects between men and women with HF and reduced ejection fraction (HFrEF) using established guideline-directed medical therapy and other emerging pharmacological treatments. Systematic search was performed on PubMed, Embase, and Cochrane Library for randomized controlled trials published in 1990-2021. Outcomes were all-cause mortality and combined outcome of all-cause mortality and/or hospitalization for HF. Of 618 articles identified, 25 articles and 100 213 patients (mean age 62 ± 1.7 years, women 23.1%, mean left ventricular ejection fraction 26.6 ± 1.3%) were included in the systematic review and meta-analysis. For the outcome of all-cause mortality, there was no evidence of treatment heterogeneity by sex for renin-angiotensin system inhibitors (RASi) [hazard ratio (HR) 0.86 (95% confidence interval 0.75-0.99) in men; HR 0.97 (0.77-1.23) in women; P Our meta-analysis showed no differences between sex in treatment effect for BB and RASi. Review on previously published trials for MRA, SGLT2i, and emerging therapies presented consistent treatment effects between men and women.
Identifiants
pubmed: 35603531
doi: 10.1002/ehf2.13974
pmc: PMC9288771
doi:
Substances chimiques
Adrenergic beta-Antagonists
0
Angiotensin Receptor Antagonists
0
Angiotensin-Converting Enzyme Inhibitors
0
Mineralocorticoid Receptor Antagonists
0
Sodium-Glucose Transporter 2 Inhibitors
0
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2753-2761Informations de copyright
© 2022 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
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