Monocyte subsets, T cell activation profiles, and stroke in men and women: The Multi-Ethnic Study of Atherosclerosis and Cardiovascular Health Study.

Atherosclerosis / epidemiology CD4-Positive T-Lymphocytes / immunology CD8-Positive T-Lymphocytes Cytokines / biosynthesis Female Follow-Up Studies Humans Incidence Inflammation Interleukin-4 / biosynthesis Ischemic Stroke / blood Lymphocyte Activation / immunology Male Monocytes / immunology Stroke / blood T-Lymphocyte Subsets / immunology
Biomarkers Epidemiology Immune cells Inflammation Stroke

Journal

Atherosclerosis
ISSN: 1879-1484
Titre abrégé: Atherosclerosis
Pays: Ireland
ID NLM: 0242543

Informations de publication

Date de publication:
06 2022
Historique:
received: 22 02 2022
revised: 20 04 2022
accepted: 11 05 2022
pubmed: 24 5 2022
medline: 9 6 2022
entrez: 23 5 2022
Statut: ppublish

Résumé

Despite mechanistic data implicating unresolving inflammation in stroke pathogenesis, data regarding circulating immune cell phenotypes - key determinants of inflammation propagation versus resolution - and incident stroke are lacking. Therefore, we aimed to comprehensively define associations of circulating immune phenotypes and activation profiles with incident stroke. We investigated circulating leukocyte phenotypes and activation profiles with incident adjudicated stroke in 2104 diverse adults from the Multi-Ethnic Study of Atherosclerosis (MESA) followed over a median of 16.6 years. Cryopreserved cells from the MESA baseline examination were thawed and myeloid and lymphoid lineage cell subsets were measured using polychromatic flow cytometry and intracellular cytokine activation staining. We analyzed multivariable-adjusted associations of cell phenotypes, as a proportion of parent cell subsets, with incident stroke (overall) and ischemic stroke using Cox regression models. We observed associations of intermediate monocytes, early-activated CD4 Circulating IL-4 producing T cells and intermediate monocytes were significantly associated with incident stroke over nearly two decades of follow-up. These associations were stronger among men and not among women. Further translational studies are warranted to define more precise targets for prognosis and intervention.

Sections du résumé

BACKGROUND AND AIMS
Despite mechanistic data implicating unresolving inflammation in stroke pathogenesis, data regarding circulating immune cell phenotypes - key determinants of inflammation propagation versus resolution - and incident stroke are lacking. Therefore, we aimed to comprehensively define associations of circulating immune phenotypes and activation profiles with incident stroke.
METHODS
We investigated circulating leukocyte phenotypes and activation profiles with incident adjudicated stroke in 2104 diverse adults from the Multi-Ethnic Study of Atherosclerosis (MESA) followed over a median of 16.6 years. Cryopreserved cells from the MESA baseline examination were thawed and myeloid and lymphoid lineage cell subsets were measured using polychromatic flow cytometry and intracellular cytokine activation staining. We analyzed multivariable-adjusted associations of cell phenotypes, as a proportion of parent cell subsets, with incident stroke (overall) and ischemic stroke using Cox regression models.
RESULTS
We observed associations of intermediate monocytes, early-activated CD4
CONCLUSIONS
Circulating IL-4 producing T cells and intermediate monocytes were significantly associated with incident stroke over nearly two decades of follow-up. These associations were stronger among men and not among women. Further translational studies are warranted to define more precise targets for prognosis and intervention.

Identifiants

DOI: 10.1016/j.atherosclerosis.2022.05.007 PMID: 35605368 PMC: PMC9548392
pubmed: 35605368
pii: S0021-9150(22)00243-X
doi: 10.1016/j.atherosclerosis.2022.05.007
pmc: PMC9548392
mid: NIHMS1838912
pii:
doi:

Substances chimiques

Cytokines 0
IL4 protein, human 0
Interleukin-4 207137-56-2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

18-25

Subventions

Organisme : NCATS NIH HHS
ID : UL1 TR001079
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL130114
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL087652
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL156792
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95165
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95159
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201500003I
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85083
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000040
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85080
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85081
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL103612
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201500003C
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95160
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL120393
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95163
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL080295
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268200800007C
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95169
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95164
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL120854
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC55222
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL135625
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95162
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85086
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95168
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL122309
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201200036C
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL144483
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201800001C
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95161
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001420
Pays : United States
Organisme : NHLBI NIH HHS
ID : 75N92021D00006
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL159964
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85082
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95167
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC85079
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95166
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG023629
Pays : United States

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

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Auteurs

Matthew J Feinstein (MJ)

Division of Cardiology in the Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Clinical and Translational Immunocardiology Program, Northwestern Medicine Bluhm Cardiovascular Institute, Chicago, IL, USA. Electronic address: matthewjfeinstein@northwestern.edu.

Petra Buzkova (P)

University of Washington, Seattle, WA, USA.

Nels C Olson (NC)

University of Vermont, Burlington, VT, USA.

Margaret F Doyle (MF)

University of Vermont, Burlington, VT, USA.

Colleen M Sitlani (CM)

University of Washington, Seattle, WA, USA.

Alison E Fohner (AE)

University of Washington, Seattle, WA, USA.

Sally A Huber (SA)

University of Vermont, Burlington, VT, USA.

James Floyd (J)

University of Washington, Seattle, WA, USA.

Arjun Sinha (A)

Division of Cardiology in the Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Clinical and Translational Immunocardiology Program, Northwestern Medicine Bluhm Cardiovascular Institute, Chicago, IL, USA.

Edward B Thorp (EB)

Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Clinical and Translational Immunocardiology Program, Northwestern Medicine Bluhm Cardiovascular Institute, Chicago, IL, USA.

Alan Landay (A)

Rush University Medical Center, Chicago, IL, USA.

Matthew S Freiberg (MS)

Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.

William T Longstreth (WT)

University of Washington, Seattle, WA, USA; Departments of Neurology and Epidemiology, University of Washington, Seattle, WA, USA.

Russell P Tracy (RP)

University of Vermont, Burlington, VT, USA.

Bruce M Psaty (BM)

Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Systems and Population Health, University of Washington, Seattle, WA, USA.

Joseph Ac Delaney (JA)

University of Manitoba, Winnipeg, Manitoba, Canada.

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Classifications MeSH

questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Artériopathies oblitérantes › Artériosclérose › Athérosclérose › Monocyte subsets, T cell activation profiles,...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Monocyte subsets, T cell activation profiles,...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Monocyte subsets, T cell activation profiles,...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Monocyte subsets, T cell activation profiles,...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études de suivi › Monocyte subsets, T cell activation profiles,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Monocyte subsets, T cell activation profiles,...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Incidence › Monocyte subsets, T cell activation profiles,...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Monocyte subsets, T cell activation profiles,...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-4 › Monocyte subsets, T cell activation profiles,...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Accident vasculaire cérébral ischémique › Monocyte subsets, T cell activation profiles,...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Monocyte subsets, T cell activation profiles,...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Monocytes › Monocyte subsets, T cell activation profiles,...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Monocyte subsets, T cell activation profiles,...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Monocyte subsets, T cell activation profiles,...