[HLA-B58.01 and allopurinol hypersensitivity renal vasculitis in a Chinese patient].
HLA-B58.01 et vascularite rénale d’hypersensibilité à l’allopurinol chez un patient chinois.
Acute kidney injury
Allopurinol
HLA-B*5801
Insuffisance rénale aiguë
Necrotizing vasculitis
Vascularite nécrosante
Journal
La Revue de medecine interne
ISSN: 1768-3122
Titre abrégé: Rev Med Interne
Pays: France
ID NLM: 8101383
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
13
01
2022
revised:
04
04
2022
accepted:
10
04
2022
pubmed:
24
5
2022
medline:
14
7
2022
entrez:
23
5
2022
Statut:
ppublish
Résumé
Allopurinol, widely used in the treatment of hyperuricemia and gout, has been shown to cause severe cutaneous reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis, as well as systemic reactions such as DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms). The HLA-B*5801 allele is known to be a risk factor for severe cutaneous manifestations of hypersensitivity to allopurinol, mostly in Asian populations. We report the observation of a 47-year-old Chinese patient, with no previous medical history, carrying the HLA-B*5801 allele, who developed an isolated allopurinol hypersensitivity necrotizing renal vasculitis without cutaneous manifestations. . The identification of this allele should be proposed before prescribing allopurinol in patients originating from certain regions of Asia, and the imputability of allopurinol should be evoked in case of necrotizing renal vasculitis, even without associated cutaneous involvement.
Identifiants
pubmed: 35606203
pii: S0248-8663(22)00439-8
doi: 10.1016/j.revmed.2022.04.018
pii:
doi:
Substances chimiques
Gout Suppressants
0
HLA-B Antigens
0
HLA-B58
0
Allopurinol
63CZ7GJN5I
Types de publication
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
436-439Informations de copyright
Copyright © 2022 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.