The Italian tremor Network (TITAN): rationale, design and preliminary findings.


Journal

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
ISSN: 1590-3478
Titre abrégé: Neurol Sci
Pays: Italy
ID NLM: 100959175

Informations de publication

Date de publication:
Sep 2022
Historique:
received: 16 03 2022
accepted: 29 04 2022
pubmed: 25 5 2022
medline: 20 8 2022
entrez: 24 5 2022
Statut: ppublish

Résumé

The recently released classification has revised the nosology of tremor, defining essential tremor (ET) as a syndrome and fueling an enlightened debate about some newly conceptualized entities such as ET-plus. As a result, precise information of demographics, clinical features, and about the natural history of these conditions are lacking. The ITAlian tremor Network (TITAN) is a multicenter data collection platform, the aim of which is to prospectively assess, according to a standardized protocol, the phenomenology and natural history of tremor syndromes. In the first year of activity, 679 patients have been recruited. The frequency of tremor syndromes varied from 32% of ET and 41% of ET-plus to less than 3% of rare forms, including focal tremors (2.30%), task-specific tremors (1.38%), isolated rest tremor (0.61%), and orthostatic tremor (0.61%). Patients with ET-plus were older and had a higher age at onset than ET, but a shorter disease duration, which might suggest that ET-plus is not a disease stage of ET. Familial aggregation of tremor and movement disorders was present in up to 60% of ET cases and in about 40% of patients with tremor combined with dystonia. The body site of tremor onset was different between tremor syndromes, with head tremor being most commonly, but not uniquely, associated with dystonia. The TITAN study is anticipated to provide clinically relevant prospective information about the clinical correlates of different tremor syndromes and their specific outcomes and might serve as a basis for future etiological, pathophysiological, and therapeutic research.

Identifiants

pubmed: 35608737
doi: 10.1007/s10072-022-06104-w
pii: 10.1007/s10072-022-06104-w
pmc: PMC9385818
doi:

Types de publication

Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

5369-5376

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2022. The Author(s).

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Auteurs

Roberto Erro (R)

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", Neuroscience Section, University of Salerno, Via Allende 43, 84081, Baronissi, SA, Italy. rerro@unisa.it.

Andrea Pilotto (A)

Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Marcello Esposito (M)

Clinical Neurophysiology Unit, AORN Cardarelli, Naples, Italy.

Enrica Olivola (E)

Neuromed Institute IRCCS, Pozzilli, IS, Italy.

Alessandra Nicoletti (A)

Department "G.F. Ingrassia", Section of Neurosciences, University of Catania, Catania, Italy.

Giulia Lazzeri (G)

Neurology Unit, Department of Neuroscience, Dino Ferrari Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Luca Magistrelli (L)

Department of Translational Medicine, Movement Disorders Centre, Neurology Unit, University of Piemonte Orientale, Novara, Italy.

Carlo Dallocchio (C)

Neurology Unit, Department of Medical Area, ASST Pavia, Voghera, PV, Italy.

Roberta Marchese (R)

IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Matteo Bologna (M)

Neuromed Institute IRCCS, Pozzilli, IS, Italy.
Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.

Alessandro Tessitore (A)

Department of Advanced Medical and Surgical Sciences, Università Della Campania "Luigi Vanvitelli", Naples, Italy.

Salvatore Misceo (S)

Neurosensory Department, Neurology Unit, San Paolo Hospital, ASL Bari, Bari, Italy.

Angelo Fabio Gigante (AF)

Neurosensory Department, Neurology Unit, San Paolo Hospital, ASL Bari, Bari, Italy.

Carmen Terranova (C)

Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

Vincenzo Moschella (V)

Neurology Unit ,San Filippo Neri Hospital ASL Roma1, Rome, Italy.

Lazzaro di Biase (L)

Neurology Unit, Campus Bio-Medico University Hospital Foundation, Rome, Italy.
Unit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, Università Campus Bio-Medico Di Roma, Rome, Italy.
Brain Innovations Lab, Università Campus Bio-Medico Di Roma, Rome, Italy.

Raffaella Di Giacopo (R)

Neurology Unit, Rovereto Hospital, APSS Trento, Rovereto, TN, Italy.

Francesca Morgante (F)

Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Neurosciences Research Centre, Molecular and Clinical Sciences Institute, St. George's, University of London, London, UK.

Francesca Valentino (F)

Parkinson's Disease and Movement Disorders Unit, IRCCS Mondino Foundation, Pavia, Italy.

Anna De Rosa (A)

Department of Neurosciences and Reproductive and Odontostomatological Sciences, Federico II University, Naples, Italy.

Assunta Trinchillo (A)

Department of Neurosciences and Reproductive and Odontostomatological Sciences, Federico II University, Naples, Italy.

Maria Chiara Malaguti (MC)

Neurology Department, S. Chiara Hospital, Trento, Italy.

Livia Brusa (L)

Neurology Department, S.Eugenio Hospital, Rome, Italy.

Angela Matinella (A)

Neurology Unit, Department of Medical Area, ASST Pavia, Voghera, PV, Italy.

Francesca Di Biasio (F)

IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Giulia Paparella (G)

Neuromed Institute IRCCS, Pozzilli, IS, Italy.

Rosa De Micco (R)

Department of Advanced Medical and Surgical Sciences, Università Della Campania "Luigi Vanvitelli", Naples, Italy.

Elena Contaldi (E)

Department of Translational Medicine, Movement Disorders Centre, Neurology Unit, University of Piemonte Orientale, Novara, Italy.

Nicola Modugno (N)

Neuromed Institute IRCCS, Pozzilli, IS, Italy.

Alessio Di Fonzo (A)

Neurology Unit, Department of Neuroscience, Dino Ferrari Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Alessandro Padovani (A)

Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Paolo Barone (P)

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", Neuroscience Section, University of Salerno, Via Allende 43, 84081, Baronissi, SA, Italy.

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