A review of the protective effects of chlorogenic acid against different chemicals.
antioxidants
chemicals toxicity
chlorogenic acid
organ toxicity
Journal
Journal of food biochemistry
ISSN: 1745-4514
Titre abrégé: J Food Biochem
Pays: United States
ID NLM: 7706045
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
revised:
17
03
2022
received:
02
12
2021
accepted:
20
04
2022
pubmed:
25
5
2022
medline:
11
9
2022
entrez:
24
5
2022
Statut:
ppublish
Résumé
Chlorogenic acid (CGA) is a naturally occurring non-flavonoid polyphenol found in green coffee beans, teas, certain fruits, and vegetables, that exerts antiviral, antitumor, antibacterial, and antioxidant effects. Several in vivo and in vitro studies have demonstrated that CGA can protect against toxicities induced by chemicals of different classes such as fungal/bacterial toxins, pharmaceuticals, metals, pesticides, etc., by preservation of cell survival via reducing overproduction of nitric oxide and reactive oxygen species and suppressed pro-apoptotic signaling. CGA antioxidant effects mediated through the Nrf2-heme oxygenase-1 signaling pathway were shown to enhance the levels of antioxidant enzymes such as superoxide dismutase, catalase, glutathione-S-transferases, glutathione peroxidase, and glutathione reductase as well as glutathione content. Also, CGA could suppress inflammation via inhibition of toll-like receptor 4 and MyD88, and the phosphorylation of inhibitor of kappa B and p65 subunit of NF-κB, resulting in diminished levels of downstream inflammatory factors including interleukin (IL)-1 β, IL-6, tumor necrosis factor-α, macrophage inflammatory protein 2, cyclooxygenase-2, and prostaglandin E2. Moreover, CGA inhibited apoptosis by reducing Bax, cytochrome C, and caspase 3 and 9 expression while increasing Bcl-2 levels. The present review discusses several mechanisms through which CGA may exert its protective role against such agents. Chemical and natural toxic agents affect human health. Phenolic antioxidant compounds can suppress free radical production and combat these toxins. Chlorogenic acid is a plant polyphenol present in the human diet and exerts strong antioxidant properties that can effectively help in the treatment of various toxicities.
Substances chimiques
Antioxidants
0
Polyphenols
0
Chlorogenic Acid
318ADP12RI
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14254Informations de copyright
© 2022 Wiley Periodicals LLC.
Références
Abbas, N. A., Awad, M. M., & Nafea, O. E. (2020). Silymarin in combination with chlorogenic acid protects against hepatotoxicity induced by doxorubicin in rats: Possible role of adenosine monophosphate-activated protein kinase pathway. Toxicology Research, 9(6), 771-777.
Ahmed, M. A., Mohanad, M., Ahmed, A. A., Aboulhoda, B. E., & El-Awdan, S. A. (2021). Mechanistic insights into the protective effects of chlorogenic acid against indomethacin-induced gastric ulcer in rats: Modulation of the cross talk between autophagy and apoptosis signaling. Life Sciences, 275, 119370.
Akhtar, T., & Sheikh, N. (2013). An overview of thioacetamide-induced hepatotoxicity. Toxin Reviews, 32(3), 43-46.
Akila, P., Asaikumar, L., & Vennila, L. (2017). Chlorogenic acid ameliorates isoproterenol-induced myocardial injury in rats by stabilizing mitochondrial and lysosomal enzymes. Biomedicine & Pharmacotherapy, 85, 582-591.
Akila, P., & Vennila, L. (2016). Chlorogenic acid a dietary polyphenol attenuates isoproterenol induced myocardial oxidative stress in rat myocardium: An in vivo study. Biomedicine & Pharmacotherapy, 84, 208-214.
Al-Rasheed, N., Faddah, L., Al-Rasheed, N., Bassiouni, Y. A., Hasan, I. H., Mahmoud, A. M., Mohamad, R. A., & Yacoub, H. I. (2016). Protective effects of silymarin, alone or in combination with chlorogenic acid and/or melatonin, against carbon tetrachloride-induced hepatotoxicity. Pharmacognosy Magazine, 12(3), S337.
Al-Rasheed, N. M., Al-Rasheed, N. M., Faddah, L., Mohamed, A. M., Mohammad, R. A., & Al-Amin, M. (2014). Potential impact of silymarin in combination with chlorogenic acid and/or melatonin in combating cardiomyopathy induced by carbon tetrachloride. Saudi Journal of Biological Sciences, 21(3), 265-274.
AL-Megrin, W. A., Metwally, D. M., Habotta, O. A., Amin, H. K., Abdel Moneim, A. E., & El-khadragy, M. (2020). Nephroprotective effects of chlorogenic acid against sodium arsenite-induced oxidative stress, inflammation, and apoptosis. Journal of the Science of Food and Agriculture, 100(14), 5162-5170.
Ali, N., Rashid, S., Nafees, S., Hasan, S. K., Shahid, A., Majed, F., & Sultana, S. (2017). Protective effect of chlorogenic acid against methotrexate induced oxidative stress, inflammation and apoptosis in rat liver: An experimental approach. Chemico-Biological Interactions, 272, 80-91.
Alkiş, İ., Suat, E., Yildirim, S., Bakir, A., Gizem, E., & Firat, M. (2020). Evaluation of the protective effect of chlorogenic acid and rhabdosciadium anatolyi against cyclophosphamide-induced ovarian toxicity in the rat with histopathological and immunohistochemical findings. Kafkas Universitesi Veteriner Fakültesi Dergisi, 26(6), 757-763.
Amirabadi, F., Tabrizian, K., Rashki, A., Rezaee, R., Tsatsakis, A. M., Arsene, A. L., Docea, A. O., Moshiri, M., & Hashemzaei, M. (2016). Lead levels in children deciduous teeth are associated with parents'education status and daily dairy consumption: An iranian experience. Farmácia, 64(2), 202-209.
Aseervatham, G. S., Suryakala, U., Sundaram, S., Bose, P. C., & Sivasudha, T. (2016). Expression pattern of NMDA receptors reveals antiepileptic potential of apigenin 8-C-glucoside and chlorogenic acid in pilocarpine induced epileptic mice. Biomedicine & Pharmacotherapy., 82, 54-64.
Avedissian, S. N., Pais, G., Liu, J., O'Donnell, J. N., Lodise, T. P., Neely, M., Prozialeck, W. C., Lamar, P. C., Becher, L., & Scheetz, M. H. (2021). The pharmacodynamic-toxicodynamic relationship of AUC and C max in vancomycin-induced kidney injury in an animal model. Antimicrobial Agents and Chemotherapy, 65(3), e01945-20.
Bakalbassis, E. G., Chatzopoulou, A., Melissas, V. S., Tsimidou, M., Tsolaki, M., & Vafiadis, A. (2001). Ab initio and density functional theory studies for the explanation of the antioxidant activity of certain phenolic acids. Lipids, 36, 181-191.
Bisht, A., Dickens, M., Rutherfurd-Markwick, K., Thota, R., Mutukumira, A. N., & Singh, H. (2020). Chlorogenic acid potentiates the anti-inflammatory activity of curcumin in LPS-stimulated THP-1 cells. Nutrients, 12(9), 2706.
Campra, N. A., Cariddi, L. N., Escobar, F. M., Sabini, M. C., Freire-de-Lima, C. G., Decote-Ricardo, D., Roma, D., & Mañas, F. (2020). Protective role of chlorogenic acid on DNA damage caused by ochratoxin A exposure. Analecta Veterinaria, 40(2), 049.
Cariddi, L., Escobar, F., Sabini, M., Campra, N., Bagnis, G., Decote-Ricardo, D., Freire-de-Lima, C. G., Mañas, F., Sabini, L. I., & Dalcero, A. (2016). Phenolic acid protects of renal damage induced by ochratoxin A in a 28-days-oral treatment in rats. Environmental Toxicology and Pharmacology, 43, 105-111.
Cariddi, L. N., Sabini, M. C., Escobar, F. M., Montironi, I., Mañas, F., Iglesias, D., Comini, L. R., Sabini, L. I., & Dalcero, A. M. (2015). Polyphenols as possible bioprotectors against cytotoxicity and DNA damage induced by ochratoxin A. Environmental Toxicology and Pharmacology, 39(3), 1008-1018.
Casanova, A. G., Hernández-Sánchez, M. T., López-Hernández, F. J., Martínez-Salgado, C., Prieto, M., Vicente-Vicente, L., & Morales, A. I. (2020). Systematic review and meta-analysis of the efficacy of clinically tested protectants of cisplatin nephrotoxicity. European Journal of Clinical Pharmacology, 76(1), 23-33.
Catanzaro, D., Filippini, R., Vianello, C., Carrara, M., Ragazzi, E., & Montopoli, M. (2016). Chlorogenic acid interaction with cisplatin and oxaliplatin: Studies in cervical carcinoma cells. Natural Product Communications, 11(4), 499-502.
Chamandoost, S., Fateh Moradi, M., & Hosseini, M.-J. (2016). A review of nitrate and nitrite toxicity in foods. Journal of Human Environment and Health Promotion, 1(2), 80-86.
Chan, B. Y., Roczkowsky, A., Cho, W. J., Poirier, M., Sergi, C., Keschrumrus, V., Churko, J. M., Granzier, H., & Schulz, R. (2021). MMP inhibitors attenuate doxorubicin cardiotoxicity by preventing intracellular and extracellular matrix remodelling. Cardiovascular Research, 117(1), 188-200.
Chauhan, P. S., Satti, N. K., Sharma, V. K., Dutt, P., Suri, K. A., & Bani, S. (2011). Amelioration of inflammatory responses by chlorogenic acid via suppression of pro-inflammatory mediators. Journal of Applied Pharmaceutical Science, 1(4), 67.
Cheng, D., Li, H., Zhou, J., & Wang, S. (2019). Chlorogenic acid relieves lead-induced cognitive impairments and hepato-renal damage via regulating the dysbiosis of the gut microbiota in mice. Food & Function, 10(2), 681-690.
Cheng, D., Song, Q., Ding, Y., Yu, Q., Liu, Y., Tian, X., Wang, M., Wang, G., & Wang, S. (2021). Comparative study on the protective effect of chlorogenic acid and 3-(3-Hydroxyphenyl) propionic acid against cadmium-induced erythrocyte cytotoxicity: In vitro and in vivo evaluation. Journal of Agricultural and Food Chemistry, 69(13), 3859-3870.
Cheng, D., Wang, G., Wang, X., Tang, J., & Li, C. (2020). Chlorogenic acid improves lipid membrane peroxidation and morphological changes in nitrite-induced erythrocyte model of methemoglobinemia. Journal of Food Biochemistry, 44(5), e13172.
Cheng, D., Wang, G., Wang, X., Tang, J., Yu, Q., Zhang, X., & Wang, S. (2020). Neuro-protection of chlorogenic acid against Al-induced apoptosis in PC12 cells via modulation of Al metabolism and Akt/GSK-3β pathway. Journal of Functional Foods, 70, 103984.
Cheng, D., Zhang, X., Tang, J., Kong, Y., Wang, X., & Wang, S. (2019). Chlorogenic acid protects against aluminum toxicity via MAPK/Akt signaling pathway in murine RAW264.7 macrophages. Journal of Inorganic Biochemistry, 190, 113-120.
Cheng, D., Zhang, X., Xu, L., Li, X., Hou, L., & Wang, C. (2017). Protective and prophylactic effects of chlorogenic acid on aluminum-induced acute hepatotoxicity and hematotoxicity in mice. Chemico-Biological Interactions, 273, 125-132.
Cheng, J. C., Dai, F., Zhou, B., Yang, L., & Liu, Z. L. (2007). Antioxidant activity of hydroxycinnamic acid derivatives in human low density lipoprotein: Mechanism and structure-activity relationship. Food Chemistry, 104, 132-139.
Clissold, S. P., & Heel, R. C. (1985). Transdermal hyoscine (scopolamine). Drugs, 29(3), 189-207.
Cornard, J.-P., Lapouge, C., Dangleterre, L., & Allet-Bodelot, C. (2008). Complexation of lead (II) by chlorogenic acid: Experimental and theoretical study. The Journal of Physical Chemistry A, 112(48), 12475-12484.
Cronstein, B. N., & Aune, T. M. (2020). Methotrexate and its mechanisms of action in inflammatory arthritis. Nature Reviews Rheumatology, 16(3), 145-154.
de Paulis, T., Schmidt, D. E., Bruchey, A. K., Kirby, M. T., McDonald, M. P., Commers, P., Lovinger, D. M., & Martin, P. R. (2002). Dicinnamoylquinides in roasted coffee inhibit the human adenosine transporter. European Journal of Pharmacology, 442(3), 215-223. https://doi.org/10.1016/S0014-2999(02)01540-6
Ding, Y., Li, X., Liu, Y., Wang, S., & Cheng, D. (2021). Protection mechanisms underlying oral administration of chlorogenic acid against cadmium-induced hepatorenal injury related to regulating intestinal flora balance. Journal of Agricultural and Food Chemistry, 69(5), 1675-1683.
Dkhil, M. A., Moneim, A. E. A., Bauomy, A. A., Khalil, M., Al-Shaebi, E. M., & Al-Quraishy, S. (2020). Chlorogenic acid prevents hepatotoxicity in arsenic-treated mice: Role of oxidative stress and apoptosis. Molecular Biology Reports, 47(2), 1161-1171.
Domitrović, R., Cvijanović, O., Šušnić, V., & Katalinić, N. (2014). Renoprotective mechanisms of chlorogenic acid in cisplatin-induced kidney injury. Toxicology, 324, 98-107.
El-Demerdash, F. M., Yousef, M. I., Kedwany, F. S., & Baghdadi, H. H. (2004). Cadmium-induced changes in lipid peroxidation, blood hematology, biochemical parameters and semen quality of male rats: Protective role of vitamin E and β-carotene. Food and Chemical Toxicology, 42(10), 1563-1571.
El-Khadragy, M. F., Al-Megrin, W. A., Alomar, S., Alkhuriji, A. F., Metwally, D. M., Mahgoub, S., Amin, H. K., Habotta, O. A., Moneim, A. E., & Albeltagy, R. S. (2021). Chlorogenic acid abates male reproductive dysfunction in arsenic-exposed mice via attenuation of testicular oxido-inflammatory stress and apoptotic responses. Chemico-Biological Interactions, 333, 109333.
Eriksson, M., Eklund, M., Borgquist, S., Hellgren, R., Margolin, S., Thoren, L., Rosendahl, A., Lång, K., Tapia, J., Bäcklund, M., & Discacciati, A. (2021). Low-dose tamoxifen for mammographic density reduction: A randomized controlled trial. Journal of Clinical Oncology, 39(17), 1899-1908.
Fang, H., WenHui, L., Yi, W., YaLi, Y., & Zheng, R. (2018). Chlorogenic acid attenuates cadmium-induced intestinal injury in rats. Shipin Kexue/Food Science, 39(17), 187-191.
Fang, S.-Q., Wang, Y.-T., Wei, J.-X., Shu, Y.-H., Xiao, L., & Lu, X.-M. (2016). Beneficial effects of chlorogenic acid on alcohol-induced damage in PC12 cells. Biomedicine & Pharmacotherapy, 79, 254-262.
Fazel Nabavi, S., Tejada, S., Setzer, W. N., Gortzi, O., Sureda, A., Braidy, N., Daglia, M., & Mohammad Nabavi, S. (2017). Chlorogenic acid and mental diseases: From chemistry to medicine. Current Neuropharmacology, 15(4), 471-479.
Flaten, T. P. (1990). Geographical associations between aluminium in drinking water and death rates with dementia (including Alzheimer's disease), Parkinson's disease and amyotrophic lateral sclerosis in Norway. Environmental Geochemistry and Health, 12(1), 152-167.
Fuentes, E., Caballero, J., Alarcon, M., Rojas, A., & Palomo, I. (2014). Chlorogenic acid inhibits human platelet activation and thrombus formation. PLoS ONE, 9(3), 90699. https://doi.org/10.1371/journal.pone.0090699
Fukutomi, R., Ohishi, T., Koyama, Y., Pervin, M., Nakamura, Y., & Isemura, M. (2021). Beneficial effects of epigallocatechin-3-O-gallate, chlorogenic acid, resveratrol, and curcumin on neurodegenerative diseases. Molecules, 26(2), 415.
Ghahhari, J., Vaezi, G., Riazi, G., Abbasi, A., Modanloo, M., & Shokrzadeh, M. (2017). The protective effect of chlorogenic acid on arsenic trioxide induced hepatotoxicity in mice. Bioscience Biotechnology Research Communications, 10(2), 165-172.
Golding, J. F., Wesnes, K. A., & Leaker, B. R. (2018). The effects of the selective muscarinic M3 receptor antagonist darifenacin, and of hyoscine (scopolamine), on motion sickness, skin conductance & cognitive function. British Journal of Clinical Pharmacology, 84(7), 1535-1543.
Guo, Z., & Li, J. (2017). Chlorogenic acid prevents alcohol-induced brain damage in neonatal rat. Translational Neuroscience, 8(1), 176-181.
Hao, M. L., Pan, N., Zhang, Q. H., & Wang, X. H. (2015). Therapeutic efficacy of chlorogenic acid on cadmium-induced oxidative neuropathy in a murine model. Experimental and Therapeutic Medicine, 9(5), 1887-1894.
Hedayati, N., Naeini, M. B., Nezami, A., Hosseinzadeh, H., Wallace Hayes, A., Hosseini, S., Imenshahidi, M., & Karimi, G. (2019). Protective effect of lycopene against chemical and natural toxins: A review. Bio Factors, 45(1), 5-23.
Holt, E. M., Steffen, L. M., Moran, A., Basu, S., Steinberger, J., Ross, J. A., Hong, C. P., & Sinaiko, A. R. (2009). Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents. Journal of the American Dietetic Association, 109(3), 414-421.
Hsu, P.-C., & Guo, Y. L. (2002). Antioxidant nutrients and lead toxicity. Toxicology, 180(1), 33-44.
Hussein, R. M., Sawy, D. M., Kandeil, M. A., & Farghaly, H. S. (2021). Chlorogenic acid, quercetin, coenzyme Q10 and silymarin modulate Keap1-Nrf2/heme oxygenase-1 signaling in thioacetamide-induced acute liver toxicity. Life Sciences, 277, 119460.
Hwang, S. J., Kim, Y.-W., Park, Y., Lee, H.-J., & Kim, K.-W. (2014). Anti-inflammatory effects of chlorogenic acid in lipopolysaccharide-stimulated RAW 264.7 cells. Inflammation Research, 63(1), 81-90.
Iranshahi, M., Barthomeuf, C., Bayet-Robert, M., Chollet, P., Davoodi, D., Piacente, S., Rezaee, R., & Sahebkar, A. (2014). Drimane-type sesquiterpene coumarins from Ferula gummosa fruits enhance doxorubicin uptake in doxorubicin-resistant human breast cancer cell line. Journal of Traditional and Complementary Medicine, 4(2), 118-125.
Jaeschke, H. (2016). Acetaminophen hepatotoxicity and sterile inflammation: The mechanism of protection of Chlorogenic acid. Chemico-Biological Interactions, 243, 148-149.
Jantararussamee, C., Rodniem, S., Taweechotipatr, M., Showpittapornchai, U., & Pradidarcheep, W. (2021). Hepatoprotective effect of probiotic lactic acid bacteria on thioacetamide-induced liver fibrosis in rats. Probiotics and Antimicrobial Proteins, 13, 40-50.
Ji, L., Jiang, P., Lu, B., Sheng, Y., Wang, X., & Wang, Z. (2013). Chlorogenic acid, a dietary polyphenol, protects acetaminophen-induced liver injury and its mechanism. The Journal of Nutritional Biochemistry, 24(11), 1911-1919.
Ji, X., Wang, B., Paudel, Y. N., Li, Z., Zhang, S., Mou, L., Liu, K., & Jin, M. (2021). Protective effect of chlorogenic acid and its analogues on lead-induced developmental neurotoxicity through modulating oxidative stress and autophagy. Frontiers in Molecular Biosciences, 8, 440.
Karcheva-Bahchevanska, D. P., Lukova, P. K., Nikolova, M. M., Mladenov, R. D., & Iliev, I. N. (2017). Effect of extracts of bilberries (Vaccinium myrtillus L.) on amyloglucosidase and α-glucosidase activity. Folia Med (Plovdiv), 59(2), 197-202.
Kapil, A., Koul, I. B., & Suri, O. P. (1995). Antihepatotoxic effects of chlorogenic acid from Anthocephalus cadamba. Phytotherapy Research, 9(3), 189-193.
Kim, H., Pan, J. H., Kim, S. H., Lee, J. H., & Park, J.-W. (2018). Chlorogenic acid ameliorates alcohol-induced liver injuries through scavenging reactive oxygen species. Biochimie, 150, 131-138.
Kim, S. H., Park, S. Y., Park, Y. L., Myung, D. S., Rew, J. S., & Joo, Y. E. (2017). Chlorogenic acid suppresses lipopolysaccharide-induced nitric oxide and interleukin-1β expression by inhibiting JAK2/STAT3 activation in RAW264.7 cells. Molecular Medicine Reports, 16(6), 9224-9232.
Kong, D., Ding, Y., Liu, J., Liu, R., Zhang, J., Zhou, Q., Long, Z., Peng, J., Li, L., Bai, H., & Hai, C. (2019). Chlorogenic acid prevents paraquat-induced apoptosis via Sirt1-mediated regulation of redox and mitochondrial function. Free Radical Research, 53(6), 680-693.
Koriem, K. M., & Soliman, R. E. (2014). Chlorogenic and caftaric acids in liver toxicity and oxidative stress induced by methamphetamine. Journal of Toxicology, 2014, 583494.
Kurisaki, E. (1989). Lung toxicity of Paraquat. Eisei. Kagaku, 35(4), 261-272.
Kwon, S. H., Lee, H. K., Kim, J. A., Hong, S. I., Kim, H. C., Jo, T. H., Park, Y. I., Lee, C. K., Kim, Y. B., Lee, S. Y., & Jang, C. G. (2010). Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice. European Journal of Pharmacology, 649(1-3), 210-217.
Lee, K., Lee, J. S., Jang, H. J., Kim, S. M., Chang, M. S., Park, S. H., Kim, K. S., Bae, J., Park, J. W., Lee, B., & Choi, H. Y. (2012). Chlorogenic acid ameliorates brain damage and edema by inhibiting matrix metalloproteinase-2 and 9 in a rat model of focal cerebral ischemia. European Journal of Pharmacology, 689(1-3), 89-95.
Leopoldini, M., Chiodo, S. G., Russo, N., & Toscano, M. (2011). Detailed investigation of the OH radical quenching by natural antioxidant caffeic acid studied by quantum mechanical models. Journal of Chemical Theory and Computation, 7(12), 4218-4233.
Li, C., Chen, W., Zheng, L., Zhang, B., Yang, X., Zhang, Q., Wang, N., Wang, Y., Yang, J., Sha, J., & Zhou, Z. (2019). Ameliorative effect of ursolic acid on ochratoxin A-induced renal cytotoxicity mediated by Lonp1/Aco2/Hsp75. Toxicon, 168, 141-146.
Li, Y., Shen, D., Tang, X., Li, X., Wo, D., Yan, H., Song, R., Feng, J., Li, P., Zhang, J., & Li, J. (2014). Chlorogenic acid prevents isoproterenol-induced hypertrophy in neonatal rat myocytes. Toxicology Letters, 226(3), 257-263.
Li, Y., Shi, W., Li, Y., Zhou, Y., Hu, X., Song, C., Ma, H., Wang, C., & Li, Y. (2008). Neuroprotective effects of chlorogenic acid against apoptosis of PC12 cells induced by methylmercury. Environmental Toxicology and Pharmacology, 26(1), 13-21.
Liao, Z. C., Yang, Z. Y., Li, Y., Wang, B. D., & Zhou, Q. X. (2013). A simple structure fluorescent chemosensor for high selectivity and sensitivity of aluminum ions. Dyes and Pigments, 97(1), 124-128.
Lu, H., Tian, Z., Cui, Y., Liu, Z., & Ma, X. (2020). Chlorogenic acid: A comprehensive review of the dietary sources, processing effects, bioavailability, beneficial properties, mechanisms of action, and future directions. Comprehensive Reviews in Food Science and Food Safety, 19(6), 3130-3158.
Lukitasari, M., Nugroho, D. A., & Widodo, N. (2018). Chlorogenic acid: The conceivable chemosensitizer leading to cancer growth suppression. Journal of Evidence-based Integrative Medicine, 23, 1-6.
Luo, J., Yang, C., Luo, X., Yang, Y., Li, J., Song, B., Zhao, J., & Li, L. (2020). Chlorogenic acid attenuates cyclophosphamide-induced rat interstitial cystitis. Life Sciences, 254, 117590.
Manibusan, M. K., Odin, M., & Eastmond, D. A. (2007). Postulated carbon tetrachloride mode of action: A review. Journal of Environmental Science and Health Part C, 25(3), 185-209.
Matei, M. F., Jaiswal, R., & Kuhnert, N. (2012). Investigating the chemical changes of chlorogenic acids during coffee brewing: Conjugate addition of water to the olefinic moiety of chlorogenic acids and their quinides. Journal of Agricultural and Food Chemistry, 60(49), 12105-12115.
Metwally, D. M., Alajmi, R. A., El-Khadragy, M. F., Yehia, H. M., AL-Megrin, W. A., Akabawy, A. M., Amin, H. K., & Moneim, A. E. (2020). Chlorogenic acid confers robust neuroprotection against arsenite toxicity in mice by reversing oxidative stress, inflammation, and apoptosis. Journal of Functional Foods, 75, 104202.
Miao, M., & Xiang, L. (2020). Pharmacological action and potential targets of chlorogenic acid. Advances in Pharmacology, 87, 71-88.
Mohammadi, H., Karimi, G., Mahdi Rezayat, S., Reza, A., Shafiee, H., Nikfar, S., Baeeri, M., Sabzevari, O., & Abdollahi, M. (2011). Benefit of nanocarrier of magnetic magnesium in rat malathion-induced toxicity and cardiac failure using non-invasive monitoring of electrocardiogram and blood pressure. Toxicology and Industrial Health, 27(5), 417-429.
Moreira, E. A., Pilon, A. C., Andrade, L. E., & Lopes, N. P. (2018). New perspectives on chlorogenic acid accumulation in harvested leaf tissue: Impact on traditional medicine preparations. ACS Omega, 3(12), 18380-18386.
Naraki, K., Rezaee, R., & Karimi, G. (2021). A review on the protective effects of naringenin against natural and chemical toxic agents. Phytotherapy Research, 35(8), 4075-4091.
Naraki, K., Rezaee, R., Mashayekhi-Sardoo, H., Hayes, A. W., & Karimi, G. (2021). Mangiferin offers protection against deleterious effects of pharmaceuticals, heavy metals, and environmental chemicals. Phytotherapy Research, 35(2), 810-822.
Necas, J., & Bartosikova, L. (2013). Carrageenan: A review. Veterinární Medicína, 58(4), 187-205.
Niu, Q. (2018). Neurotoxicity of Aluminum (Vol. 1091). Springer.
Nwafor, E. O., Lu, P., Zhang, Y., Liu, R., Peng, H., Xing, B., Liu, Y., Li, Z., Zhang, K., Zhang, Y., & Liu, Z. (2022). Chlorogenic acid: Potential source of natural drugs for the therapeutics of fibrosis and cancer. Translational Oncology, 15(1), 101294.
Onakpoya, I., Spencer, E., Thompson, M., & Heneghan, C. (2015). The effect of chlorogenic acid on blood pressure: A systematic review and meta-analysis of randomized clinical trials. Journal of Human Hypertension, 29(2), 77-81.
Owumi, S. E., Anaikor, R. A., Arunsi, U. O., Adaramoye, O. A., & Oyelere, A. K. (2021). Chlorogenic acid co-administration abates tamoxifen-mediated reproductive toxicities in male rats: An experimental approach. Journal of Food Biochemistry, 45(2), e13615.
Owumi, S. E., Olusola, K. J., Arunsi, O. U., & Oyelere, K. A. (2021). Chlorogenic acid abates oxido-inflammatory and apoptotic responses in the liver and kidney of tamoxifen-treated rats. Toxicology Research, 10(2), 345-353.
Pabla, N., & Dong, Z. (2008). Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies. Kidney International, 73(9), 994-1007.
Palócz, O., Pászti-Gere, E., Gálfi, P., & Farkas, O. (2016). Chlorogenic acid combined with Lactobacillus plantarum 2142 reduced LPS-induced intestinal inflammation and oxidative stress in IPEC-J2 cells. PLoS ONE, 11(11), e0166642.
Palumbo, J. D., O'Keeffe, T. L., & Mahoney, N. E. (2007). Inhibition of ochratoxin A production and growth of Aspergillus species by phenolic antioxidant compounds. Mycopathologia, 164(5), 241-248.
Pang, C., Sheng, Y. C., Jiang, P., Wei, H., & Ji, L. (2015). Chlorogenic acid prevents acetaminophen-induced liver injury: The involvement of CYP450 metabolic enzymes and some antioxidant signals. Journal of Zhejiang University-Science B, 16(7), 602-610.
Pınar, N., Çakırca, G., Hakverdi, S., & Kaplan, M. (2020). Protective effect of alpha lipoic acid on cisplatin induced hepatotoxicity in rats. Biotechnic & Histochemistry, 95(3), 219-224.
Qu, S., Dai, C., Hao, Z., Tang, Q., Wang, H., Wang, J., & Zhao, H. (2020). Chlorogenic acid prevents vancomycin-induced nephrotoxicity without compromising vancomycin antibacterial properties. Phytotherapy Research, 34(12), 3189-3199.
Ramachandran, A., & Jaeschke, H. (2017). Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology. Journal of Clinical and Translational Research, 3(1), 157.
Renouf, M., Guy, P. A., Marmet, C., Fraering, A. L., Longet, K., Moulin, J., Enslen, M., Barron, D., Dionisi, F., Cavin, C., & Williamson, G. (2010). Measurement of caffeic and ferulic acid equivalents in plasma after coffee consumption: Small intestine and colon are key sites for coffee metabolism. Molecular Nutrition & Food Research, 54(6), 760-766.
Ruifeng, G., Yunhe, F., Zhengkai, W., Yimeng, L., Minjun, Y., Xiaojing, S., Zhengtao, Y., & Naisheng, Z. (2014). Chlorogenic acid attenuates lipopolysaccharide-induced mice mastitis by suppressing TLR4-mediated NF-κB signaling pathway. European Journal of Pharmacology, 729, 54-58.
Sato, Y., Itagaki, S., Kurokawa, T., Ogura, J., Kobayashi, M., Hirano, T., Sugawara, M., & Iseki, K. (2011). In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid. International Journal of Pharmaceutics, 403(1-2), 136-138.
Santana-Gálvez, J., Cisneros-Zevallos, L., & Jacobo-Velázquez, D. A. (2017). Chlorogenic acid: Recent advances on its dual role as a food additive and a nutraceutical against metabolic syndrome. Molecules, 22(3), 358.
Sasaki, K., Alamed, J., Weiss, J., Villeneuve, P., Giraldo, L. J., Lecomte, J., Figueroa-Espinoza, M. C., & Decker, E. A. (2010). Relationship between the physical properties of chlorogenic acid esters and their ability to inhibit lipid oxidation in oil-in-water emulsions. Food Chemistry, 118(3), 830-835.
Shan, J., Fu, J., Zhao, Z., Kong, X., Huang, H., Luo, L., & Yin, Z. (2009). Chlorogenic acid inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264. 7 cells through suppressing NF-κB and JNK/AP-1 activation. International Immunopharmacology, 9(9), 1042-1048.
Shapiro, H., Ashkenazi, M., Weizman, N., Shahmurov, M., Aeed, H., & Bruck, R. (2006). Curcumin ameliorates acute thioacetamide-induced hepatotoxicity. Journal of Gastroenterology and Hepatology, 21(2), 358-366.
Shen, W., Qi, R., Zhang, J., Wang, Z., Wang, H., Hu, C., Zhao, Y., Bie, M., Wang, Y., Fu, Y., & Chen, M. (2012). Chlorogenic acid inhibits LPS-induced microglial activation and improves survival of dopaminergic neurons. Brain Research Bulletin, 88(5), 487-494.
Shi, H., Dong, L., Bai, Y., Zhao, J., Zhang, Y., & Zhang, L. (2009). Chlorogenic acid against carbon tetrachloride-induced liver fibrosis in rats. European Journal of Pharmacology, 623(1-3), 119-124.
Shi, H., Dong, L., Dang, X., Liu, Y., Jiang, J., Wang, Y., Lu, X., & Guo, X. (2013). Effect of chlorogenic acid on LPS-induced proinflammatory signaling in hepatic stellate cells. Inflammation Research, 62(6), 581-587.
Shi, J., Chang, X., Zou, H., Gu, J., Yuan, Y., Liu, X., Liu, Z., & Bian, J. (2021). Protective effects of α-lipoic acid and chlorogenic acid on cadmium-induced liver injury in three-yellow chickens. Animals, 11(6), 1606.
Shirani, K., Yousefsani, B. S., Shirani, M., & Karimi, G. (2020). Protective effects of naringin against drugs and chemical toxins induced hepatotoxicity: A review. Phytotherapy Research, 34(8), 1734-1744.
Shokrzadeh, M., Bagheri, A., Ghassemi-Barghi, N., Rahmanian, N., & Eskandani, M. (2021). Doxorubicin and doxorubicin-loaded nanoliposome induce senescence by enhancing oxidative stress, hepatotoxicity, and in vivo genotoxicity in male Wistar rats. Naunyn-Schmiedeberg's Archives of Pharmacology, 394(8), 1803-1813.
Song, Z., Zhu, J., Wei, Q., Dong, G., & Dong, Z. (2020). Canagliflozin reduces cisplatin uptake and activates Akt to protect against cisplatin-induced nephrotoxicity. American Journal of Physiology-Renal Physiology, 318(4), F1041-F1052.
Spinks, A., & Wasiak, J. (2011). Scopolamine (hyoscine) for preventing and treating motion sickness. Cochrane Database of Systematic Reviews, 6, CD002851.
Sritharan, S., & Sivalingam, N. (2021). A comprehensive review on time-tested anticancer drug doxorubicin. Life Sciences, 278, 119527.
Stalmach, A., Mullen, W., Barron, D., Uchida, K., Yokota, T., Cavin, C., Steiling, H., Williamson, G., & Crozier, A. (2009). Metabolite profiling of hydroxycinnamate derivatives in plasma and urine after the ingestion of coffee by humans: Identification of biomarkers of coffee consumption. Drug Metabolism and Disposition, 37(8), 1749-1758.
Stalmach, A., Steiling, H., Williamson, G., & Crozier, A. (2010). Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. Archives of Biochemistry and Biophysics, 501(1), 98-105.
Stoev, S. D. (2021). Follow up long term preliminary studies on carcinogenic and toxic effects of ochratoxin A in rats and the putative protection of phenylalanine. Toxicon, 190, 41-49.
Su, J., Liu, D., Wang, Q., Lin, J., Song, S., & Huang, K. (2019). Long-time instead of short-time exposure in vitro and administration in vivo of ochratoxin A is consistent in immunosuppression. Journal of Agricultural and Food Chemistry, 67(26), 7485-7495.
Summ, O., Andreou, A. P., Akerman, S., Holland, P. R., Hoffmann, J., & Goadsby, P. J. (2021). Differential actions of indomethacin: Clinical relevance in headache. Pain, 162(2), 591.
Sun, Z. X., Liu, S., Zhao, Z. Q., & Su, R. Q. (2014). Protective effect of chlorogenic acid against carbon tetrachloride-induced acute liver damage in rats. Chinese Herbal Medicines, 6(1), 36-41.
Tian, L., Su, C. P., Wang, Q., Wu, F. J., Bai, R., Zhang, H. M., Liu, J. Y., Lu, W. J., Wang, W., Lan, F., & Guo, S. Z. (2019). Chlorogenic acid: A potent molecule that protects cardiomyocytes from TNF-α-induced injury via inhibiting NF-κB and JNK signals. Journal of Cellular and Molecular Medicine, 23(7), 4666-4678.
Tsuchiya, T., Suzuki, O., & Igarashi, K. (1996). Protective effects of chlorogenic acid on paraquat-induced oxidative stress in rats. Bioscience, Biotechnology, and Biochemistry, 60(5), 765-768.
Türkan, F., Calimli, M. H., Kanberoğlu, G. S., & Karaman, M. (2021). Inhibition effects of isoproterenol, chlorpromazine, carbamazepine, tamoxifen drugs on glutathione S-transferase, cholinesterases enzymes and molecular docking studies. Journal of Biomolecular Structure and Dynamics, 39(9), 3277-3284.
Tyler, C. R., & Allan, A. M. (2014). The effects of arsenic exposure on neurological and cognitive dysfunction in human and rodent studies: A review. Current Environmental Health Reports, 1(2), 132-147.
Un, H., Ugan, R. A., Kose, D., Bayir, Y., Cadirci, E., Selli, J., & Halici, Z. (2020). A novel effect of Aprepitant: Protection for cisplatin-induced nephrotoxicity and hepatotoxicity. European Journal of Pharmacology, 880, 173168.
Vardi, N., Parlakpinar, H., & Ates, B. (2012). Beneficial effects of chlorogenic acid on methotrexate-induced cerebellar Purkinje cell damage in rats. Journal of Chemical Neuroanatomy, 43(1), 43-47.
Ventura-Lima, J., Bogo, M. R., & Monserrat, J. M. (2011). Arsenic toxicity in mammals and aquatic animals: A comparative biochemical approach. Ecotoxicology and Environmental Safety, 74(3), 211-218.
Wan, C. W., Wong, C. N., Pin, W. K., Wong, M. H., Kwok, C. Y., Chan, R. Y., Yu, P. H., & Chan, S. W. (2013). Chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up-regulating the gene expression of PPAR-α in hypercholesterolemic rats induced with a high-cholesterol diet. Phytotherapy Research, 27(4), 545-551.
Wang, J., Li, J., Liu, J., Xu, M., Tong, X., & Wang, J. (2016). Chlorogenic acid prevents isoproterenol-induced DNA damage in vascular smooth muscle cells. Molecular Medicine Reports, 14(5), 4063-4068.
Wang, X., Fan, X., Yuan, S., Jiao, W., Liu, B., Cao, J., & Jiang, W. (2017). Chlorogenic acid protects against aluminium-induced cytotoxicity through chelation and antioxidant actions in primary hippocampal neuronal cells. Food & Function, 8(8), 2924-2934.
Wang, X., Xi, Y., Zeng, X., Zhao, H., Cao, J., & Jiang, W. (2018). Effects of chlorogenic acid against aluminium neurotoxicity in ICR mice through chelation and antioxidant actions. Journal of Functional Foods, 40, 365-376.
Wei, M., Zheng, Z., Shi, L., Jin, Y., & Ji, L. (2018). Natural polyphenol chlorogenic acid protects against acetaminophen-induced hepatotoxicity by activating ERK/Nrf2 antioxidative pathway. Toxicological Sciences, 162(1), 99-112.
Xu, D., Hu, L., Xia, X., Song, J., Li, L., Song, E., & Song, Y. (2014). Tetrachlorobenzoquinone induces acute liver injury, up-regulates HO-1 and NQO1 expression in mice model: The protective role of chlorogenic acid. Environmental Toxicology and Pharmacology, 37(3), 1212-1220.
Xu, Y., Chen, J., Yu, X., Tao, W., Jiang, F., Yin, Z., & Liu, C. (2010). Protective effects of chlorogenic acid on acute hepatotoxicity induced by lipopolysaccharide in mice. Inflammation Research, 59(10), 871-877.
Xue, Y., Huang, F., Tang, R., Fan, Q., Zhang, B., Xu, Z., Sun, X., & Ruan, Z. (2019). Chlorogenic acid attenuates cadmium-induced intestinal injury in Sprague-Dawley rats. Food and Chemical Toxicology, 133, 110751.
Yan, Y., Zhou, X., Guo, K., Zhou, F., & Yang, H. (2020). Chlorogenic acid protects against indomethacin-induced inflammation and mucosa damage by decreasing bacteroides-derived LPS. Frontiers in Immunology, 11, 1125.
Yarmohammadi, F., Hayes, A. W., & Karimi, G. (2021). Protective effects of curcumin on chemical and drug-induced cardiotoxicity: A review. Naunyn-Schmiedeberg's Archives of Pharmacology, 394(7), 1341-1353.
Yarmohammadi, F., Rezaee, R., Haye, A. W., & Karimi, G. (2021). Endoplasmic reticulum stress in doxorubicin-induced cardiotoxicity may be therapeutically targeted by natural and chemical compounds: A review. Pharmacological Research, 164, 105383.
Yarmohammadi, F., Rezaee, R., & Karimi, G. (2021). Natural compounds against doxorubicin-induced cardiotoxicity: A review on the involvement of Nrf2/ARE signaling pathway. Phytotherapy Research, 35(3), 1163-1175.
Ye, H. Y., Jin, J., Jin, L. W., Chen, Y., Zhou, Z. H., & Li, Z. Y. (2017). Chlorogenic acid attenuates lipopolysaccharide-induced acute kidney injury by inhibiting TLR4/NF-κB signal pathway. Inflammation, 40(2), 523-529.
Ye, H. Y., Li, Z. Y., Zheng, Y., Chen, Y., Zhou, Z. H., & Jin, J. (2016). The attenuation of chlorogenic acid on oxidative stress for renal injury in streptozotocin-induced diabetic nephropathy rats. Archives of Pharmacal Research, 39(7), 989-997.
Youn, Y., Jeon, S. H., Jin, H. Y., Che, D. N., Jang, S. I., & Kim, Y. S. (2019). Chlorogenic acid-rich Solanum melongena extract has protective potential against rotenone-induced neurotoxicity in PC-12 cells. Journal of Food Biochemistry, 43(11), e12999.
Zahir, F., Rizwi, S. J., Haq, S. K., & Khan, R. H. (2005). Low dose mercury toxicity and human health. Environmental Toxicology and Pharmacology, 20(2), 351-360.
Zargar, S. (2014). Protective effect of Trigonella foenum-graecum on thioacetamide induced hepatotoxicity in rats. Saudi Journal of Biological Sciences, 21(2), 139-145.
Zhang, L. T., Chang, C. Q., Liu, Y., & Che, Z. M. (2011). Effect of chlorogenic acid on disordered glucose and lipid metabolism in db/db mice and its mechanism. Acta Academiae Medicinae Sinicae, 33(3), 281-286.
Zhang, S., Sun, B., Wang, D., Liu, Y., Li, J., Qi, J., Zhang, Y., Bai, C., & Liang, S. (2021). Chlorogenic acid ameliorates damage induced by fluorene-9-bisphenol in porcine sertoli cells. Frontiers in Pharmacology, 12, 1464.
Zhang, T., Chen, S., Chen, L., Zhang, L., Meng, F., Sha, S., Ai, C., & Tai, J. (2019). Chlorogenic acid ameliorates lead-induced renal damage in mice. Biological Trace Element Research, 189(1), 109-117.
Zhang, T., Dang, M., Zhang, W., & Lin, X. (2020). Gold nanoparticles synthesized from Euphorbia fischeriana root by green route method alleviates the isoprenaline hydrochloride induced myocardial infarction in rats. Journal of Photochemistry and Photobiology B: Biology, 202, 111705.
Zhang, X., Huang, H., Yang, T., Ye, Y., Shan, J., Yin, Z., & Luo, L. (2010). Chlorogenic acid protects mice against lipopolysaccharide-induced acute lung injury. Injury, 41(7), 746-752.
Zhao, Y., Wang, J., Ballevre, O., Luo, H., & Zhang, W. (2012). Antihypertensive effects and mechanisms of chlorogenic acids. Hypertension Research, 35(4), 370-374.
Zheng, L. F., Dai, F., Zhou, B., Yang, L., & Liu, Z. L. (2008). Prooxidant activity of hydroxycinnamic acids on DNA damage in the presence of Cu (II) ions: Mechanism and structure-activity relationship. Food and Chemical Toxicology, 46, 149-156.
Zheng, Z., Sheng, Y., Lu, B., & Ji, L. (2015). The therapeutic detoxification of chlorogenic acid against acetaminophen-induced liver injury by ameliorating hepatic inflammation. Chemico-Biological Interactions, 238, 93-101.
Zhou, J., Ashoori, F., Suzuki, S., Nishigaki, I., & Yagi, K. (1993). Protective effect of chlorogenic acid on lipid peroxidation induced in the liver of rats by carbon tetrachloride or 60Co-irradiation. Journal of Clinical Biochemistry and Nutrition, 15(2), 119-125.