iBCS: 2. Mechanistic Modeling of Pulmonary Availability of Inhaled Drugs versus Critical Product Attributes.

biopharmaceutics classification system critical product attributes iBCS inhaled drugs mechanistic modeling pulmonary availability

Journal

Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791

Informations de publication

Date de publication:
04 07 2022
Historique:
pubmed: 25 5 2022
medline: 8 7 2022
entrez: 24 5 2022
Statut: ppublish

Résumé

This work is the second in a series of publications outlining the fundamental principles and proposed design of a biopharmaceutics classifications system for inhaled drugs and drug products (the iBCS). Here, a mechanistic computer-based model has been used to explore the sensitivity of the primary biopharmaceutics functional output parameters: (i) pulmonary fraction dose absorbed (

Identifiants

pubmed: 35609877
doi: 10.1021/acs.molpharmaceut.2c00112
pmc: PMC9257747
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2040-2047

Références

Lancet. 2000 Aug 12;356(9229):556-61
pubmed: 10950233
AAPS J. 2015 Jul;17(4):999-1010
pubmed: 25933600
Mol Pharm. 2015 Aug 3;12(8):2618-24
pubmed: 26091361
CPT Pharmacometrics Syst Pharmacol. 2016 Apr;5(4):201-10
pubmed: 27104089
J Appl Physiol (1985). 2021 Mar 1;130(3):678-707
pubmed: 33180641
Pharm Res. 1995 Mar;12(3):413-20
pubmed: 7617530
Clin Pharmacol Ther. 2017 Mar;101(3):331-340
pubmed: 27727445
Mol Pharm. 2022 Jul 4;19(7):2032-2039
pubmed: 35576168
Thorax. 2003 Mar;58(3):258-60
pubmed: 12612308
J Aerosol Med Pulm Drug Deliv. 2017 Apr;30(2):108-117
pubmed: 27740878
Eur J Pharm Sci. 2018 Feb 15;113:41-52
pubmed: 29079338
J Aerosol Med Pulm Drug Deliv. 2019 Feb;32(1):1-12
pubmed: 29878860
Pharm Res. 1993 Sep;10(9):1308-14
pubmed: 8234168
Adv Drug Deliv Rev. 2014 May;71:15-33
pubmed: 24530633
Mol Pharm. 2014 May 5;11(5):1707-14
pubmed: 24735251
AAPS J. 2015 Jul;17(4):853-70
pubmed: 25845315
Br J Radiol. 1986 Feb;59(698):147-51
pubmed: 3947822
Clin Pharmacol Ther. 2016 Sep;100(3):223-31
pubmed: 27037630
AAPS J. 2013 Jan;15(1):159-71
pubmed: 23139018
Ann ICRP. 1994;24(1-3):1-482
pubmed: 7726471
J Aerosol Med Pulm Drug Deliv. 2016 Aug;29(4):362-77
pubmed: 26859446

Auteurs

Per Bäckman (P)

Emmace Consulting AB, Medicon Village, Scheelevägen 2, Lund SE-223 81, Sweden.

Antonio Cabal (A)

Eisai, Woodcliff Lake, New Jersey 07677, United States.

Andy Clark (A)

Aerogen Pharma, San Mateo, California 94402, United States.

Carsten Ehrhardt (C)

Trinity College Dublin, Dublin 2, Ireland.

Ben Forbes (B)

King's College London, London WC2R 2LS, U.K.

Jayne Hastedt (J)

JDP Pharma Consulting, San Carlos, California 94070, United States.

Anthony Hickey (A)

University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
RTI International, Research Triangle Park, North Carolina 27709, United States.

Guenther Hochhaus (G)

University of Florida, Gainesville, Florida 32611, United States.

Wenlei Jiang (W)

Center for Drug Evaluation and Research, Office of Generic Drugs, Office of Research and Standards, U.S. FDA, Silver Spring, Maryland 20993, United States.

Stavros Kassinos (S)

University of Cyprus, Nicosia 1678, Cyprus.

Philip J Kuehl (PJ)

Lovelace Biomedical, Albuquerque, New Mexico 87108, United States.

David Prime (D)

Pulmonary Drug Delivery Consultant, Ware SG12, U.K.

Yoen-Ju Son (YJ)

Genentech, South San Francisco, California 94080, United States.

Simon P Teague (SP)

GlaxoSmithKline, Stevenage SG1 2NY, U.K.

Ulrika Tehler (U)

Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Gothenburg 43183, Sweden.

Jennifer Wylie (J)

Merck & Co., Inc., Kenilworth, New Jersey 07033, United States.

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Classifications MeSH