Skeletal muscle provides the immunological micro-milieu for specific plasma cells in anti-synthetase syndrome-associated myositis.
Anti-synthetase syndrome
Jo-1
PL-12
PL-7
Pathophysiology
Plasma cells
Journal
Acta neuropathologica
ISSN: 1432-0533
Titre abrégé: Acta Neuropathol
Pays: Germany
ID NLM: 0412041
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
21
12
2021
accepted:
13
05
2022
revised:
08
04
2022
pubmed:
26
5
2022
medline:
20
7
2022
entrez:
25
5
2022
Statut:
ppublish
Résumé
Anti-synthetase syndrome (ASyS)-associated myositis is a major subgroup of the idiopathic inflammatory myopathies (IIM) and is characterized by disease chronicity with musculoskeletal, dermatological and pulmonary manifestations. One of eight autoantibodies against the aminoacyl-transferase RNA synthetases (ARS) is detectable in the serum of affected patients. However, disease-specific therapeutic approaches have not yet been established.To obtain a deeper understanding of the underlying pathogenesis and to identify putative therapeutic targets, we comparatively investigated the most common forms of ASyS associated with anti-PL-7, anti-PL-12 and anti-Jo-1. Our cohort consisted of 80 ASyS patients as well as healthy controls (n = 40), diseased controls (n = 40) and non-diseased controls (n = 20). We detected a reduced extent of necrosis and regeneration in muscle biopsies from PL-12
Identifiants
pubmed: 35612662
doi: 10.1007/s00401-022-02438-z
pii: 10.1007/s00401-022-02438-z
pmc: PMC9288384
doi:
Substances chimiques
Autoantibodies
0
Ligases
EC 6.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
353-372Informations de copyright
© 2022. The Author(s).
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