Experimental approaches for manipulating choroid plexus epithelial cells.
Adeno-associated virus (AAV)
Blood-cerebrospinal fluid barrier (BCSFB)
Cerebrospinal fluid (CSF)
Chemogenetics
Choroid plexus (ChP)
Gene therapy
Journal
Fluids and barriers of the CNS
ISSN: 2045-8118
Titre abrégé: Fluids Barriers CNS
Pays: England
ID NLM: 101553157
Informations de publication
Date de publication:
26 May 2022
26 May 2022
Historique:
received:
31
12
2021
accepted:
14
04
2022
entrez:
26
5
2022
pubmed:
27
5
2022
medline:
31
5
2022
Statut:
epublish
Résumé
Choroid plexus (ChP) epithelial cells are crucial for the function of the blood-cerebrospinal fluid barrier (BCSFB) in the developing and mature brain. The ChP is considered the primary source and regulator of CSF, secreting many important factors that nourish the brain. It also performs CSF clearance functions including removing Amyloid beta and potassium. As such, the ChP is a promising target for gene and drug therapy for neurodevelopmental and neurological disorders in the central nervous system (CNS). This review describes the current successful and emerging experimental approaches for targeting ChP epithelial cells. We highlight methodological strategies to specifically target these cells for gain or loss of function in vivo. We cover both genetic models and viral gene delivery systems. Additionally, several lines of reporters to access the ChP epithelia are reviewed. Finally, we discuss exciting new approaches, such as chemical activation and transplantation of engineered ChP epithelial cells. We elaborate on fundamental functions of the ChP in secretion and clearance and outline experimental approaches paving the way to clinical applications.
Identifiants
pubmed: 35619113
doi: 10.1186/s12987-022-00330-2
pii: 10.1186/s12987-022-00330-2
pmc: PMC9134666
doi:
Substances chimiques
Amyloid beta-Peptides
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
36Subventions
Organisme : NICHD NIH HHS
ID : P50 HD105351
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS088566
Pays : United States
Organisme : New York Stem Cell Foundation
ID : NYSCF-R-NI38
Organisme : NIH NINDS
ID : NS088566
Informations de copyright
© 2022. The Author(s).
Références
Genesis. 2014 Apr;52(4):350-8
pubmed: 24550157
Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6232-6
pubmed: 1631115
Hum Gene Ther. 2017 Jul;28(7):576-587
pubmed: 28462595
Aging Cell. 2020 Sep 21;:e13239
pubmed: 32964663
Oncogene. 2006 Jan 19;25(3):487-91
pubmed: 16186803
Nat Genet. 2003 Sep;35(1):70-5
pubmed: 12923530
Cereb Cortex. 2009 Jul;19 Suppl 1:i120-5
pubmed: 19395528
Nucleic Acids Res. 1999 Nov 15;27(22):4324-7
pubmed: 10536138
Neuron. 2019 Apr 3;102(1):263
pubmed: 30946822
J Neurosci. 2012 Nov 7;32(45):15934-45
pubmed: 23136431
Front Neurosci. 2014 Nov 14;8:363
pubmed: 25452709
Acta Med Austriaca. 1992;19 Suppl 1:25-8
pubmed: 1519447
Neuron. 2015 Mar 04;85(5):942-58
pubmed: 25741722
Genesis. 2009 Jul;47(7):447-55
pubmed: 19415627
Mol Ther. 2021 Nov 3;29(11):3140-3152
pubmed: 34601132
PLoS One. 2015 Mar 27;10(3):e0121738
pubmed: 25815836
J Neurosci Res. 2020 Mar;98(3):469-470
pubmed: 31840283
Mol Ther. 2021 Feb 3;29(2):464-488
pubmed: 33309881
Gene Ther. 2005 Oct;12(20):1503-8
pubmed: 15944733
Anat Rec. 1980 Aug;197(4):495-502
pubmed: 7212299
Cell. 2008 Nov 14;135(4):738-48
pubmed: 19013281
Nat Rev Drug Discov. 2019 May;18(5):358-378
pubmed: 30710128
Elife. 2021 Jul 14;10:
pubmed: 34259630
Brain Res. 2010 Nov 4;1359:1-13
pubmed: 20732308
Cell Mol Life Sci. 2018 Feb;75(3):375-383
pubmed: 28780589
Methods Mol Biol. 2016;1408:207-25
pubmed: 26965125
Hum Gene Ther. 2020 Apr;31(7-8):440-447
pubmed: 32056463
Proteomics. 2006 Nov;6(22):5941-52
pubmed: 17051638
Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11388-E11396
pubmed: 30413620
Adv Exp Med Biol. 2010;670:80-91
pubmed: 20384220
Development. 2021 Jan 20;148(2):
pubmed: 33334860
Dev Biol. 2013 Jul 15;379(2):229-34
pubmed: 23648512
Nucleic Acids Res. 2007;35(5):1402-10
pubmed: 17284462
Development. 1998 Jun;125(12):2315-25
pubmed: 9584130
Fluids Barriers CNS. 2018 Aug 16;15(1):22
pubmed: 30111340
Acta Neuropathol. 2018 Mar;135(3):337-361
pubmed: 29368213
Am J Respir Cell Mol Biol. 2007 May;36(5):515-9
pubmed: 17255554
Nature. 2020 Feb;578(7794):229-236
pubmed: 32051598
Development. 2021 May 15;148(10):
pubmed: 34032267
Nat Commun. 2020 May 1;11(1):2141
pubmed: 32358538
Bioessays. 2008 Mar;30(3):237-48
pubmed: 18293362
Nat Commun. 2018 Mar 14;9(1):1062
pubmed: 29540683
Curr Aging Sci. 2010 Dec;3(3):219-29
pubmed: 20735345
Neurobiol Aging. 2007 May;28(5):713-8
pubmed: 16698124
PLoS One. 2012;7(6):e39835
pubmed: 22745832
Trends Pharmacol Sci. 2014 Feb;35(2):63-75
pubmed: 24412421
Neurosci Behav Physiol. 2000 Sep-Oct;30(5):509-12
pubmed: 11037140
Neurosci Res. 2022 Apr;177:38-51
pubmed: 34968558
Nat Neurosci. 2003 May;6(5):453-60
pubmed: 12652306
Cancer Res. 2019 May 1;79(9):2208-2219
pubmed: 30885981
J Control Release. 2016 Nov 10;241:94-109
pubmed: 27637390
Development. 2005 Aug;132(15):3549-59
pubmed: 15975937
PLoS One. 2008 Sep 03;3(9):e3114
pubmed: 18769591
Genome Biol. 2017 May 17;18(1):92
pubmed: 28511701
Fluids Barriers CNS. 2020 May 6;17(1):35
pubmed: 32375819
J Neurosci Res. 2020 Mar;98(3):471-480
pubmed: 31544973
Development. 2013 Mar;140(5):1055-66
pubmed: 23364326
J Neurosci. 2005 Nov 23;25(47):10884-93
pubmed: 16306401
Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3900-5
pubmed: 10097135
Mol Ther. 2011 Dec;19(12):2114-23
pubmed: 21878905
Int J Biomed Sci. 2017 Jun;13(2):48-57
pubmed: 28824341
Neurosci Lett. 2010 Jan 29;469(3):283-8
pubmed: 19800935
J Neurosci. 1999 Aug 1;19(15):6275-89
pubmed: 10414957
Methods Mol Biol. 2013;945:13-29
pubmed: 23097098
Nature. 2013 Sep 19;501(7467):373-9
pubmed: 23995685
Gene. 2000 Feb 22;244(1-2):47-54
pubmed: 10689186
Nat Neurosci. 2022 Jan;25(1):106-115
pubmed: 34887588
Curr Gene Ther. 2016;16(3):156-67
pubmed: 27216914
Cell Rep. 2013 Jun 27;3(6):1815-23
pubmed: 23770240
Nat Immunol. 2012 Nov;13(11):1092-100
pubmed: 23001146
Nat Biotechnol. 2016 Feb;34(2):204-9
pubmed: 26829320
Neurobiol Dis. 2006 Aug;23(2):471-80
pubmed: 16777422
J Virol. 2001 Dec;75(24):12382-92
pubmed: 11711628
Sci Transl Med. 2021 Feb 10;13(580):
pubmed: 33568518
Biol Open. 2012 Dec 15;1(12):1200-3
pubmed: 23259054
Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E358-67
pubmed: 26733686
Neuroscience. 2011 Mar 17;177:195-206
pubmed: 21241779
Genesis. 2007 Sep;45(9):593-605
pubmed: 17868096
Dev Cell. 2020 Feb 10;52(3):261-275
pubmed: 32049038
Cell Transplant. 2008;16(10):987-92
pubmed: 18351014
Nat Methods. 2020 May;17(5):541-550
pubmed: 32313222
J Neurosci. 2005 Oct 12;25(41):9321-7
pubmed: 16221840
Brain Res Bull. 2018 Oct;143:155-170
pubmed: 30449731
Methods Cell Biol. 2015;127:19-35
pubmed: 25837384
eNeuro. 2019 May 7;6(2):
pubmed: 31064838
J Virol. 2003 Jun;77(12):7034-40
pubmed: 12768022
Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):
pubmed: 33526661
Neuron. 2011 Mar 10;69(5):893-905
pubmed: 21382550
Brain Res. 2002 Dec 27;958(2):371-80
pubmed: 12470873
Pharmaceutics. 2020 Oct 14;12(10):
pubmed: 33066423
Development. 2009 Aug;136(15):2535-43
pubmed: 19570847
J Neuroimmunol. 2008 Aug 13;199(1-2):133-41
pubmed: 18539342
Annu Rev Neurosci. 2009;32:149-84
pubmed: 19555289
Nat Genet. 1999 Sep;23(1):99-103
pubmed: 10471508
Curr Opin Virol. 2014 Aug;7:108-18
pubmed: 25047752
Biomolecules. 2021 Apr 20;11(4):
pubmed: 33924076
Neurobiol Aging. 2019 Jun;78:18-28
pubmed: 30851437
Int J Mol Sci. 2021 Aug 19;22(16):
pubmed: 34445655
Science. 2020 Jul 10;369(6500):
pubmed: 32527923
Front Neuroanat. 2014 Aug 05;8:66
pubmed: 25147505
Mol Ther. 2006 Jul;14(1):14-24
pubmed: 16624622
Life Sci. 2020 Oct 15;259:118165
pubmed: 32735884
Physiol Rev. 2013 Oct;93(4):1847-92
pubmed: 24137023
J Neurosci. 2015 Mar 25;35(12):4903-16
pubmed: 25810521
Front Pharmacol. 2018 Jan 18;8:950
pubmed: 29403373
EMBO J. 2019 Sep 2;38(17):e100481
pubmed: 31304985
Nat Commun. 2018 Jun 4;9(1):2167
pubmed: 29867199
Nat Commun. 2019 Apr 2;10(1):1498
pubmed: 30940800
Transgenic Res. 2012 Feb;21(1):113-30
pubmed: 21538071
Elife. 2021 Jan 18;10:
pubmed: 33459592
J Mol Biol. 1981 Aug 25;150(4):467-86
pubmed: 6276557
Physiol Rev. 1971 Apr;51(2):273-311
pubmed: 4930496
Nat Commun. 2021 Jan 19;12(1):447
pubmed: 33469018
Bio Protoc. 2020 Feb 20;10(4):e3532
pubmed: 33654756
Nat Chem Biol. 2016 Dec;12(12):1059-1064
pubmed: 27723747
Hum Gene Ther. 2005 Jan;16(1):49-56
pubmed: 15703488
Adv Drug Deliv Rev. 2012 May 15;64(7):614-28
pubmed: 22119441
PLoS One. 2008 Sep 01;3(9):e3090
pubmed: 18769618
J Neuropathol Exp Neurol. 1998 Oct;57(10):885-94
pubmed: 9786239
Pediatr Neurol. 2019 Nov;100:3-11
pubmed: 31371124
Am J Pathol. 2018 Jun;188(6):1334-1344
pubmed: 29545198
J Neurosci. 2006 Jul 26;26(30):7811-9
pubmed: 16870726
Mol Ther. 2010 Dec;18(12):2075-84
pubmed: 20859261
Hum Gene Ther. 2011 Jun;22(6):745-51
pubmed: 21175294
Mol Ther Nucleic Acids. 2013 Jun 25;2:e101
pubmed: 23799375
Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4424-9
pubmed: 20142482
CNS Neurol Disord Drug Targets. 2020;19(5):386-399
pubmed: 32640968
Int J Mol Sci. 2020 May 07;21(9):
pubmed: 32392694
Cell. 2021 May 27;184(11):3056-3074.e21
pubmed: 33932339
PLoS One. 2013;8(3):e59759
pubmed: 23544095
Nat Rev Neurosci. 2015 Aug;16(8):445-57
pubmed: 26174708
Nat Rev Drug Discov. 2015 Oct;14(10):721-31
pubmed: 26361349
Sci Rep. 2014 Jul 01;4:5506
pubmed: 24981028
Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4489-94
pubmed: 11904364
Nat Rev Neurosci. 2017 Mar 17;18(4):222-235
pubmed: 28303019
Nat Rev Mol Cell Biol. 2017 Jul;18(7):423-436
pubmed: 28400610
Cell. 2001 Jun 1;105(5):599-612
pubmed: 11389830
Dev Cell. 2020 Dec 7;55(5):617-628.e6
pubmed: 33038331
Neuroscience. 2006;138(2):501-10
pubmed: 16414198
Front Biosci. 2003 May 01;8:s515-21
pubmed: 12700093
Genes Cells. 2021 Jun;26(6):399-410
pubmed: 33811429
PLoS One. 2019 Nov 14;14(11):e0225206
pubmed: 31725765
Methods. 1998 Apr;14(4):381-92
pubmed: 9608509
Neuropathol Appl Neurobiol. 1979 Aug;5(4):303-9
pubmed: 481702
Neuro Oncol. 2013 Mar;15(3):255-67
pubmed: 23172371
Biol Open. 2018 Feb 2;7(2):
pubmed: 29437557
J Neural Eng. 2009 Dec;6(6):065001
pubmed: 19850973
Neuron. 2020 Nov 25;108(4):623-639.e10
pubmed: 32961128
BMC Neurosci. 2011 Jan 07;12:4
pubmed: 21214926
Cell. 2020 Apr 2;181(1):136-150
pubmed: 32243786
Pharm Res. 2005 Jul;22(7):1011-37
pubmed: 16028003
Genesis. 2000 Feb;26(2):99-109
pubmed: 10686599
Life Sci Alliance. 2021 Sep 20;4(11):
pubmed: 34544751
iScience. 2021 Feb 07;24(3):102157
pubmed: 33665575
Front Neurosci. 2014 Nov 10;8:364
pubmed: 25426018