Effect of statins combined or not combined with metformin on polycystic ovary syndrome: A systematic review and meta-analysis.
meta-analysis
polycystic ovary syndrome
statin
Journal
The journal of obstetrics and gynaecology research
ISSN: 1447-0756
Titre abrégé: J Obstet Gynaecol Res
Pays: Australia
ID NLM: 9612761
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
revised:
10
05
2022
received:
15
03
2022
accepted:
13
05
2022
pubmed:
28
5
2022
medline:
7
7
2022
entrez:
27
5
2022
Statut:
ppublish
Résumé
This meta-analysis was conducted to evaluate the effect of statins combined or not combined with metformin on polycystic ovary syndrome (PCOS). Databases were systematically searched from inception to February 2022. Meta-analysis was conducted by using STATA 12.0 software. In the study, standard mean difference (SMD) and 95% confidence intervals (CI) were computed as the effect size. A random effect model was used. Meta-analysis showed significant decline of total testosterone, free testosterone, dehydroepiandrosterone sulphate, androstenedione, luteinizing hormone (LH), LH to follicle-stimulating hormone (FSH) ratio, and prolactin in statin group. Our study also demonstrated significant decline of total cholesterol, low-density lipoprotein cholesterol, and triglycerides in statin group. Moreover, we found significant decline of fasting glucose, insulin sensitivity index, and high-sensitivity C-reactive protein. The meta-analysis showed that statin therapy was good for women with PCOS, and could improve clinical signs of PCOS.
Sections du résumé
BACKGROUND
BACKGROUND
This meta-analysis was conducted to evaluate the effect of statins combined or not combined with metformin on polycystic ovary syndrome (PCOS).
METHODS
METHODS
Databases were systematically searched from inception to February 2022. Meta-analysis was conducted by using STATA 12.0 software. In the study, standard mean difference (SMD) and 95% confidence intervals (CI) were computed as the effect size. A random effect model was used.
RESULTS
RESULTS
Meta-analysis showed significant decline of total testosterone, free testosterone, dehydroepiandrosterone sulphate, androstenedione, luteinizing hormone (LH), LH to follicle-stimulating hormone (FSH) ratio, and prolactin in statin group. Our study also demonstrated significant decline of total cholesterol, low-density lipoprotein cholesterol, and triglycerides in statin group. Moreover, we found significant decline of fasting glucose, insulin sensitivity index, and high-sensitivity C-reactive protein.
CONCLUSION
CONCLUSIONS
The meta-analysis showed that statin therapy was good for women with PCOS, and could improve clinical signs of PCOS.
Substances chimiques
Hydroxymethylglutaryl-CoA Reductase Inhibitors
0
Hypoglycemic Agents
0
Insulin
0
Testosterone
3XMK78S47O
Luteinizing Hormone
9002-67-9
Follicle Stimulating Hormone
9002-68-0
Metformin
9100L32L2N
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1806-1815Informations de copyright
© 2022 Japan Society of Obstetrics and Gynecology.
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