CD2-negative lymphoma-associated T-cells: a potential mechanism of immune-evasion in diffuse large B-cell lymphoma.
CD2
CD58
Diffuse large B-cell lymphoma
Immune evasion
Lymphoma-associated lymphoid cells
Journal
Virchows Archiv : an international journal of pathology
ISSN: 1432-2307
Titre abrégé: Virchows Arch
Pays: Germany
ID NLM: 9423843
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
24
02
2022
accepted:
18
05
2022
revised:
04
05
2022
pubmed:
28
5
2022
medline:
12
10
2022
entrez:
27
5
2022
Statut:
ppublish
Résumé
CD2 is a costimulatory protein expressed in all mature T/NK-cells, in particular memory T-cells. CD58 (or LFA-3) is the receptor for CD2 and is ubiquitously expressed. CD2-CD58 interaction has key functions in T-cell activation and organization of the immunological synapse between T- and antigen-presenting cells. Cancer cells have developed multiple mechanisms to evade immune surveillance. Loss of CD58 expression is one frequently reported in diffuse large B-cell lymphomas (DLBCL). On the other hand, in non-hematological neoplasms, tumor infiltrating lymphocytes (TILs) with reduced expression of CD2 have been associated with defective cytotoxicity and T-cell exhaustion. Here, we reported a case of DLBCL involving the jejunal mucosa associated with a rim of cytotoxic reactive T-cells with features of immune evasion (CD2- and TCR-) and T-cell exhaustion (PD1 + high). This case likely exemplifies a previously unrecognized immune evasion mechanism in lymphoma involving a decreased CD2 expression in the lymphoma-associated T-cells.
Identifiants
pubmed: 35622145
doi: 10.1007/s00428-022-03348-x
pii: 10.1007/s00428-022-03348-x
doi:
Substances chimiques
CD2 Antigens
0
CD58 Antigens
0
Receptors, Antigen, T-Cell
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
659-663Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Challa-Malladi M, Lieu YK, Califano O, Holmes AB, Bhagat G, Murty VV, Dominguez-Sola D, Pasqualucci L, Dalla-Favera R (2011) Combined genetic inactivation of beta2-Microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma. Cancer Cell 20:728–740. https://doi.org/10.1016/j.ccr.2011.11.006
doi: 10.1016/j.ccr.2011.11.006
pubmed: 22137796
pmcid: 3660995
Demetriou P, Abu-Shah E, Valvo S, McCuaig S, Mayya V, Kvalvaag A, Starkey T, Korobchevskaya K, Lee LYW, Friedrich M, Mann E, Kutuzov MA, Morotti M, Wietek N, Rada H, Yusuf S, Afrose J, Siokis A, Oxford IBDCI, Meyer-Hermann M, Ahmed AA, Depoil D, Dustin ML (2020) A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals. Nat Immunol 21:1232–1243. https://doi.org/10.1038/s41590-020-0770-x
doi: 10.1038/s41590-020-0770-x
pubmed: 32929275
pmcid: 7611174
Demetriou P, Abu-Shah E, Valvo S, McCuaig S, Mayya V, Kvalvaag A, Starkey T, Korobchevskaya K, Lee LYW, Friedrich M, Mann E, Kutuzov MA, Morotti M, Wietek N, Rada H, Yusuf S, Afrose J, Siokis A, Oxford IBDCI, Meyer-Hermann M, Ahmed AA, Depoil D, Dustin ML (2021) Author correction: a dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals. Nat Immunol 22:99. https://doi.org/10.1038/s41590-020-00825-w
doi: 10.1038/s41590-020-00825-w
pubmed: 33122852
Dustin ML, Olszowy MW, Holdorf AD, Li J, Bromley S, Desai N, Widder P, Rosenberger F, van der Merwe PA, Allen PM, Shaw AS (1998) A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts. Cell 94:667–677. https://doi.org/10.1016/s0092-8674(00)81608-6
doi: 10.1016/s0092-8674(00)81608-6
pubmed: 9741631
Koneru M, Monu N, Schaer D, Barletta J, Frey AB (2006) Defective adhesion in tumor infiltrating CD8+ T cells. J Immunol 176:6103–6111. https://doi.org/10.4049/jimmunol.176.10.6103
doi: 10.4049/jimmunol.176.10.6103
pubmed: 16670319
McKinney EF, Lee JC, Jayne DR, Lyons PA, Smith KG (2015) T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection. Nature 523:612–616. https://doi.org/10.1038/nature14468
doi: 10.1038/nature14468
pubmed: 26123020
pmcid: 4623162
Menter T, Tzankov A (2018) Mechanisms of immune evasion and immune modulation by lymphoma cells. Front Oncol 8:54. https://doi.org/10.3389/fonc.2018.00054
doi: 10.3389/fonc.2018.00054
pubmed: 29564225
pmcid: 5845888
Otsuka Y, Nishikori M, Arima H, Izumi K, Kitawaki T, Hishizawa M, Takaori-Kondo A (2020) EZH2 inhibitors restore epigenetically silenced CD58 expression in B-cell lymphomas. Mol Immunol 119:35–45. https://doi.org/10.1016/j.molimm.2020.01.006
doi: 10.1016/j.molimm.2020.01.006
pubmed: 31962268
Palomero T, Couronne L, Khiabanian H, Kim MY, Ambesi-Impiombato A, Perez-Garcia A, Carpenter Z, Abate F, Allegretta M, Haydu JE, Jiang X, Lossos IS, Nicolas C, Balbin M, Bastard C, Bhagat G, Piris MA, Campo E, Bernard OA, Rabadan R, Ferrando AA (2014) Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas. Nat Genet 46:166–170. https://doi.org/10.1038/ng.2873
doi: 10.1038/ng.2873
pubmed: 24413734
pmcid: 3963408
Sanchez-Madrid F, Krensky AM, Ware CF, Robbins E, Strominger JL, Burakoff SJ, Springer TA (1982) Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3. Proc Natl Acad Sci U S A 79:7489–7493. https://doi.org/10.1073/pnas.79.23.7489
doi: 10.1073/pnas.79.23.7489
pubmed: 6984191
pmcid: 347365
Siokis A, Robert PA, Demetriou P, Dustin ML, Meyer-Hermann M (2018) F-actin-driven CD28-CD80 localization in the immune synapse. Cell Rep 24:1151–1162. https://doi.org/10.1016/j.celrep.2018.06.114
doi: 10.1016/j.celrep.2018.06.114
pubmed: 30067972