Identification of UDP-Glucuronosyltransferase 2B15 (UGT2B15) as a Target for IGF1 and Insulin Action.
Animals
Glucuronosyltransferase
/ genetics
Glycosyltransferases
/ metabolism
Growth Hormone
/ metabolism
Humans
Insulin
/ metabolism
Insulin-Like Growth Factor I
/ metabolism
Laron Syndrome
/ genetics
Mammals
/ metabolism
Neoplasms
/ metabolism
RNA, Messenger
/ genetics
Tumor Suppressor Protein p53
/ genetics
Uridine Diphosphate
Laron syndrome
UGT2B15
growth hormone receptor
insulin-like growth factor-1 (IGF1)
p53
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
12 05 2022
12 05 2022
Historique:
received:
04
04
2022
revised:
06
05
2022
accepted:
10
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
1
6
2022
Statut:
epublish
Résumé
Normal growth and development in mammals are tightly controlled by numerous genetic factors and metabolic conditions. The growth hormone (GH)-insulin-like growth factor-1 (IGF1) hormonal axis is a key player in the regulation of these processes. Dysregulation of the GH-IGF1 endocrine system is linked to a number of pathologies, ranging from growth deficits to cancer. Laron syndrome (LS) is a type of dwarfism that results from mutation of the GH receptor (
Identifiants
pubmed: 35626664
pii: cells11101627
doi: 10.3390/cells11101627
pmc: PMC9139319
pii:
doi:
Substances chimiques
IGF1 protein, human
0
Insulin
0
RNA, Messenger
0
Tumor Suppressor Protein p53
0
Uridine Diphosphate
58-98-0
Insulin-Like Growth Factor I
67763-96-6
Growth Hormone
9002-72-6
Glycosyltransferases
EC 2.4.-
Glucuronosyltransferase
EC 2.4.1.17
UDP-glucuronosyltransferase 2B15, human
EC 2.4.1.17
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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