The Effect of Activated FXIII, a Transglutaminase, on Vascular Smooth Muscle Cells.
cell proliferation
collagen secretion
factor XIII
thrombospondin-1
vascular smooth muscle cell
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 May 2022
23 May 2022
Historique:
received:
13
04
2022
revised:
18
05
2022
accepted:
20
05
2022
entrez:
28
5
2022
pubmed:
29
5
2022
medline:
1
6
2022
Statut:
epublish
Résumé
Plasma factor XIII (pFXIII) is a heterotetramer of FXIII-A and FXIII-B subunits. The cellular form (cFXIII), a dimer of FXIII-A, is present in a number of cell types. Activated FXIII (FXIIIa), a transglutaminase, plays an important role in clot stabilization, wound healing, angiogenesis and maintenance of pregnancy. It has a direct effect on vascular endothelial cells and fibroblasts, which have been implicated in the development of atherosclerotic plaques. Our aim was to explore the effect of FXIIIa on human aortic smooth muscle cells (HAoSMCs), another major cell type in the atherosclerotic plaque. Osteoblastic transformation induced by Pi and Ca
Identifiants
pubmed: 35628664
pii: ijms23105845
doi: 10.3390/ijms23105845
pmc: PMC9144255
pii:
doi:
Substances chimiques
RNA, Messenger
0
Thrombospondin 1
0
Collagen
9007-34-5
Factor XIIIa
EC 2.3.2.13
Transglutaminases
EC 2.3.2.13
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research, Development and Innovation Office (NKFIH), Hungary
ID : K129287
Organisme : University of Debrecen, Faculty of Medicine
ID : Research grant
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