Mitochondrial matrix-localized Src kinase regulates mitochondrial morphology.
Cellular respiration
Mitochondria-shaping protein
Mitochondrial dynamics
Oxidative phosphorylation
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
30 May 2022
30 May 2022
Historique:
received:
15
11
2021
accepted:
22
04
2022
revised:
19
04
2022
entrez:
31
5
2022
pubmed:
1
6
2022
medline:
3
6
2022
Statut:
epublish
Résumé
The architecture of mitochondria adapts to physiological contexts: while mitochondrial fragmentation is usually associated to quality control and cell death, mitochondrial elongation often enhances cell survival during stress. Understanding how these events are regulated is important to elucidate how mitochondrial dynamics control cell fate. Here, we show that the tyrosine kinase Src regulates mitochondrial morphology. Deletion of Src increased mitochondrial size and reduced cellular respiration independently of mitochondrial mass, mitochondrial membrane potential or ATP levels. Re-expression of Src targeted to the mitochondrial matrix, but not of Src targeted to the plasma membrane, rescued mitochondrial morphology in a kinase activity-dependent manner. These findings highlight a novel function for Src in the control of mitochondrial dynamics.
Identifiants
pubmed: 35637383
doi: 10.1007/s00018-022-04325-y
pii: 10.1007/s00018-022-04325-y
pmc: PMC9151517
doi:
Substances chimiques
src-Family Kinases
EC 2.7.10.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
327Subventions
Organisme : Medical Research Council
ID : MC_UU_00015/7
Pays : United Kingdom
Informations de copyright
© 2022. The Author(s).
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