A multilocus genetic study evidences the association of autoimmune-related genes with Psoriatic Arthritis in Italian patients.
Alleles
Aminopeptidases
/ genetics
Arthritis, Psoriatic
/ genetics
Case-Control Studies
Genetic Predisposition to Disease
Genotype
Humans
Interleukin-10
/ genetics
Minor Histocompatibility Antigens
Polymorphism, Single Nucleotide
RNA
/ genetics
STAT4 Transcription Factor
/ genetics
Tumor Necrosis Factor alpha-Induced Protein 3
/ genetics
Autoimmune-related genes
Genetic susceptibility
Polymorphisms
Psoriatic Arthritis
Journal
Immunobiology
ISSN: 1878-3279
Titre abrégé: Immunobiology
Pays: Netherlands
ID NLM: 8002742
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
received:
09
02
2022
revised:
28
04
2022
accepted:
21
05
2022
pubmed:
2
6
2022
medline:
3
8
2022
entrez:
1
6
2022
Statut:
ppublish
Résumé
Psoriatic Arthritis (PsA) is an immune-mediated rheumatic disease caused by the interaction between environmental factors and genetic predisposition. Many of the risk loci associated with PsA susceptibility are shared with other autoimmune diseases, suggesting an involvement of the same pathways in these diseases. We investigated the association between nine selected polymorphisms and PsA susceptibility and their possible role in the modulation of the disease activity. We analysed 163 patients with PsA and 298 age and sex-matched healthy subjects. Our results showed the associations of five polymorphisms with the disease development: rs33980500 (TRAF3IP2), rs6920220 (TNFAIP3), rs27524 (ERAP1), rs7574865 (STAT4) and rs1800872 (IL10). Patients carrying the variant allele of TRAF3IP2 polymorphism had a higher number of tender/swollen joints and a higher Disease Activity Index for PsA score. The multilocus genetic risk profile showed a higher probability to develop the disease in subjects with at least four risk alleles.
Identifiants
pubmed: 35642993
pii: S0171-2985(22)00058-4
doi: 10.1016/j.imbio.2022.152232
pii:
doi:
Substances chimiques
IL10 protein, human
0
Minor Histocompatibility Antigens
0
STAT4 Transcription Factor
0
STAT4 protein, human
0
TRAF3IP2-AS1 antisense RNA, human
0
Interleukin-10
130068-27-8
RNA
63231-63-0
Aminopeptidases
EC 3.4.11.-
ERAP1 protein, human
EC 3.4.11.-
TNFAIP3 protein, human
EC 3.4.19.12
Tumor Necrosis Factor alpha-Induced Protein 3
EC 3.4.19.12
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
152232Informations de copyright
Copyright © 2022 Elsevier GmbH. All rights reserved.