PET Imaging of Cholinergic Neurotransmission in Neurodegenerative Disorders.
Alzheimer disease
Lewy body disorder
PET
acetylcholine
neurodegenerative disorder
neurology
Journal
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
23
03
2022
revised:
06
05
2022
entrez:
1
6
2022
pubmed:
2
6
2022
medline:
7
6
2022
Statut:
ppublish
Résumé
As a neuromodulator, the neurotransmitter acetylcholine plays an important role in cognitive, mood, locomotor, sleep/wake, and olfactory functions. In the pathophysiology of most neurodegenerative diseases, such as Alzheimer disease (AD) or Lewy body disorder (LBD), cholinergic receptors, transporters, or enzymes are involved and relevant as imaging targets. The aim of this review is to summarize current knowledge on PET imaging of cholinergic neurotransmission in neurodegenerative diseases. For PET imaging of presynaptic vesicular acetylcholine transporters (VAChT), (-)-
Identifiants
pubmed: 35649648
pii: jnumed.121.263198
doi: 10.2967/jnumed.121.263198
doi:
Substances chimiques
Cholinergic Agents
0
Acetylcholine
N9YNS0M02X
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
33S-44SInformations de copyright
© 2022 by the Society of Nuclear Medicine and Molecular Imaging.