Preparation and identification of dipeptidyl peptidase IV inhibitory peptides from quinoa protein.

Caco-2 Cells Chenopodium quinoa / metabolism Chromatography, Liquid Diabetes Mellitus, Type 2 Dipeptidyl Peptidase 4 / metabolism Dipeptidyl-Peptidase IV Inhibitors / chemistry Humans Molecular Docking Simulation Pepsin A Peptides / chemistry Protein Hydrolysates / chemistry Tandem Mass Spectrometry Trypsin
Bioactive peptide Dipeptidyl peptidase IV Molecular docking Peptide identification Quinoa protein Type 2 diabetes

Journal

Food research international (Ottawa, Ont.)
ISSN: 1873-7145
Titre abrégé: Food Res Int
Pays: Canada
ID NLM: 9210143

Informations de publication

Date de publication:
06 2022
Historique:
received: 12 01 2022
revised: 16 03 2022
accepted: 17 03 2022
entrez: 2 6 2022
pubmed: 3 6 2022
medline: 7 6 2022
Statut: ppublish

Résumé

The objective of this study was to investigate the dipeptidyl peptidase IV (DPP-IV) inhibitory properties of quinoa protein-derived peptides. After germination, quinoa protein was extracted and then hydrolyzed by different enzymes such as papain, Alcalase, Neutrase, and Flavourzyme and pepsin-trypsin digestion. Results showed that the quinoa protein hydrolysates (QPH) by pepsin-trypsin digestion displayed the highest DPP-IV inhibitory activity. When ultrafiltrated, the fraction of quinoa protein hydrolysate with molecular weight less than 1 kDa (QPH1) exhibited a superior DPP-IV inhibitory activity with IC

Identifiants

DOI: 10.1016/j.foodres.2022.111176 PMID: 35651037
pubmed: 35651037
pii: S0963-9969(22)00233-2
doi: 10.1016/j.foodres.2022.111176
pii:
doi:

Substances chimiques

Dipeptidyl-Peptidase IV Inhibitors 0
Peptides 0
Protein Hydrolysates 0
Dipeptidyl Peptidase 4 EC 3.4.14.5
Trypsin EC 3.4.21.4
Pepsin A EC 3.4.23.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

111176

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Auteurs

Haixi You (H)

College of Food Science and Engineering, Northwest A&F University, Yangling 712100, PR China.

Tianliang Wu (T)

College of Food Science and Engineering, Northwest A&F University, Yangling 712100, PR China.

Wei Wang (W)

College of Food Science and Engineering, Northwest A&F University, Yangling 712100, PR China.

Yiju Li (Y)

College of Food Science and Engineering, Northwest A&F University, Yangling 712100, PR China.

Xuebo Liu (X)

College of Food Science and Engineering, Northwest A&F University, Yangling 712100, PR China. Electronic address: xueboliu@nwsuaf.edu.cn.

Long Ding (L)

College of Food Science and Engineering, Northwest A&F University, Yangling 712100, PR China. Electronic address: longding@nwafu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules Caco-2 › Preparation and identification of dipeptidyl...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Caryophyllanae › Caryophyllales › Amaranthaceae › Chenopodium › Chenopodium quinoa › Preparation and identification of dipeptidyl...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Preparation and identification of dipeptidyl...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Preparation and identification of dipeptidyl...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Dipeptidyl peptidase 4 › Preparation and identification of dipeptidyl...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Inhibiteurs de la dipeptidyl-peptidase IV › Preparation and identification of dipeptidyl...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Preparation and identification of dipeptidyl...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Preparation and identification of dipeptidyl...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › Aspartic acid endopeptidases › Pepsine A › Preparation and identification of dipeptidyl...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Preparation and identification of dipeptidyl...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hydrolysats de protéines › Preparation and identification of dipeptidyl...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Preparation and identification of dipeptidyl...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Protéases à sérine › Serine endopeptidases › Trypsine › Preparation and identification of dipeptidyl...