Ubiquitin-regulating effector proteins from Legionella.
Journal
BMB reports
ISSN: 1976-670X
Titre abrégé: BMB Rep
Pays: Korea (South)
ID NLM: 101465334
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
20
03
2022
pubmed:
3
6
2022
medline:
29
7
2022
entrez:
2
6
2022
Statut:
ppublish
Résumé
Ubiquitin is relatively modest in size but involves almost entire cellular signaling pathways. The primary role of ubiquitin is maintaining cellular protein homeostasis. Ubiquitination regulates the fate of target proteins using the proteasome- or autophagymediated degradation of ubiquitinated substrates, which can be either intracellular or foreign proteins from invading pathogens. Legionella, a gram-negative intracellular pathogen, hinders the host-ubiquitin system by translocating hundreds of effector proteins into the host cell's cytoplasm. In this review, we describe the current understanding of ubiquitin machinery from Legionella. We summarize structural and biochemical differences between the host-ubiquitin system and ubiquitin-related effectors of Legionella. Some of these effectors act much like canonical host-ubiquitin machinery, whereas others have distinctive structures and accomplish non-canonical ubiquitination via novel biochemical mechanisms. [BMB Reports 2022; 55(7): 316-322].
Substances chimiques
Bacterial Proteins
0
Ubiquitin
0
Types de publication
News
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
316-322Références
Cell Rep. 2018 Apr 10;23(2):568-583
pubmed: 29642013
PLoS Pathog. 2009 Dec;5(12):e1000704
pubmed: 20041211
Cell. 2016 Dec 1;167(6):1636-1649.e13
pubmed: 27912065
Annu Rev Biochem. 2009;78:363-97
pubmed: 19489724
Cell. 2013 Jul 3;154(1):169-84
pubmed: 23827681
Mol Cell. 2021 Nov 4;81(21):4527-4539.e8
pubmed: 34407442
Clin Microbiol Rev. 2002 Jul;15(3):506-26
pubmed: 12097254
EMBO J. 2006 Apr 19;25(8):1635-45
pubmed: 16601694
Cell Rep. 2020 Sep 8;32(10):108107
pubmed: 32905772
Nature. 2019 Aug;572(7769):382-386
pubmed: 31330532
Nat Struct Biol. 2003 Apr;10(4):250-5
pubmed: 12627222
Cell. 1999 Mar 5;96(5):645-53
pubmed: 10089880
Mol Cell. 2012 Oct 12;48(1):87-97
pubmed: 22902562
Nature. 2011 Mar 31;471(7340):591-6
pubmed: 21455173
J Biol Chem. 1990 May 25;265(15):8354-7
pubmed: 2160452
Nat Commun. 2021 Jul 1;12(1):4055
pubmed: 34210965
Nature. 2019 Aug;572(7769):387-391
pubmed: 31330531
Mol Cell. 2020 Jan 2;77(1):164-179.e6
pubmed: 31732457
Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11364-9
pubmed: 10500182
Elife. 2020 Nov 13;9:
pubmed: 33185526
Nat Commun. 2020 Apr 14;11(1):1774
pubmed: 32286321
Cell Death Differ. 2021 Oct;28(10):2957-2969
pubmed: 34285384
Science. 1989 Mar 24;243(4898):1576-83
pubmed: 2538923
mBio. 2021 Oct 26;12(5):e0231621
pubmed: 34488448
J Biol Chem. 2004 Feb 6;279(6):3916-24
pubmed: 14638690
Hum Mol Genet. 2004 Apr 15;13(8):807-17
pubmed: 14976165
Nat Biotechnol. 2003 Mar;21(3):255-61
pubmed: 12610572
Virus Res. 2017 Mar 15;232:13-21
pubmed: 28119118
Infect Immun. 2010 Sep;78(9):3905-19
pubmed: 20547746
Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23518-23526
pubmed: 31690664
Nat Rev Microbiol. 2014 Jun;12(6):399-413
pubmed: 24801936
J Biol Chem. 2020 Feb 7;295(6):1646-1657
pubmed: 31907282
Nat Rev Mol Cell Biol. 2009 May;10(5):319-31
pubmed: 19352404
Proteins. 2022 Apr;90(4):947-958
pubmed: 34825414
Nat Rev Mol Cell Biol. 2016 Oct;17(10):626-42
pubmed: 27485899
Biochem J. 2014 Mar 15;458(3):421-37
pubmed: 24576094
Annu Rev Biochem. 2017 Jun 20;86:159-192
pubmed: 28498721
Structure. 2015 Aug 4;23(8):1459-1469
pubmed: 26146184
EMBO J. 2019 May 2;38(9):
pubmed: 30886050
Nature. 2018 May;557(7707):734-738
pubmed: 29795347
Nature. 2018 May;557(7707):729-733
pubmed: 29795346
Adv Exp Med Biol. 2011;691:107-14
pubmed: 21153314
Cell Rep. 2015 Jan 13;10(2):226-38
pubmed: 25578731
J Bacteriol. 2022 Jan 18;204(1):e0037621
pubmed: 34633867
Nat Rev Mol Cell Biol. 2009 Nov;10(11):755-64
pubmed: 19851334
Biochem J. 2009 Mar 1;418(2):379-90
pubmed: 18954305
Protein Sci. 2018 Aug;27(8):1354-1363
pubmed: 29663561
EMBO J. 2020 Aug 3;39(15):e105127
pubmed: 32567101
Nat Microbiol. 2019 Aug;4(8):1282-1293
pubmed: 31110362
Immunity. 2010 Jul 23;33(1):60-70
pubmed: 20637659
EMBO J. 2007 Nov 14;26(22):4634-45
pubmed: 17948050
Annu Rev Biochem. 2009;78:399-434
pubmed: 19489725
Cell. 2013 Jun 6;153(6):1312-26
pubmed: 23746843
Cell. 2012 Jun 8;149(6):1192-205
pubmed: 22682243
Science. 2019 May 24;364(6442):787-792
pubmed: 31123136
Front Cell Infect Microbiol. 2020 Aug 21;10:448
pubmed: 32974222
EMBO J. 2006 Oct 18;25(20):4877-87
pubmed: 17006537
Structure. 2010 Aug 11;18(8):955-65
pubmed: 20696396
Adv Sci (Weinh). 2020 Apr 30;7(12):2000871
pubmed: 32596129
Nature. 2018 May;557(7707):674-678
pubmed: 29795342
Proc Natl Acad Sci U S A. 1975 Jan;72(1):11-5
pubmed: 1078892
BMC Biol. 2012 Mar 15;10:23
pubmed: 22420778
Nat Cell Biol. 2009 Feb;11(2):123-32
pubmed: 19136968
Nat Commun. 2020 May 12;11(1):2365
pubmed: 32398758
Nat Struct Mol Biol. 2014 Apr;21(4):301-7
pubmed: 24699078
Front Mol Biosci. 2021 Nov 16;8:770320
pubmed: 34869597
Cell. 2018 May 17;173(5):1231-1243.e16
pubmed: 29731171
EMBO J. 2000 Jan 4;19(1):94-102
pubmed: 10619848
EMBO J. 2020 Feb 17;39(4):e102806
pubmed: 31825121
Nat Commun. 2021 Oct 26;12(1):6174
pubmed: 34702826
PLoS Pathog. 2010 Dec 02;6(12):e1001216
pubmed: 21151961
Mol Cell Proteomics. 2013 Dec;12(12):3444-52
pubmed: 24187339
Science. 2012 Nov 23;338(6110):1072-6
pubmed: 23112293
Mol Microbiol. 2008 Mar;67(6):1307-19
pubmed: 18284575
Mol Cell. 2014 Nov 6;56(3):360-375
pubmed: 25284222
Mol Cell. 2013 Mar 7;49(5):884-96
pubmed: 23416107
Nat Cell Biol. 2016 May 27;18(6):579-86
pubmed: 27230526
Annu Rev Biochem. 2012;81:291-322
pubmed: 22482907
Mol Cell Biol. 2013 Oct;33(20):4095-105
pubmed: 23959799
Annu Rev Biochem. 1998;67:425-79
pubmed: 9759494
Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4639-47
pubmed: 27385826
Nature. 2016 May 5;533(7601):120-4
pubmed: 27049943
Mol Cell. 2018 Apr 5;70(1):150-164.e6
pubmed: 29576527
Biochem J. 2008 Apr 15;411(2):249-60
pubmed: 18254724
Mol Biol Evol. 2002 Dec;19(12):2039-50
pubmed: 12446796