Recent structural advances towards understanding of the bacterial type III secretion injectisome.
cryoelectron microscopy
host–pathogen interactions
type III secretion systems
Journal
Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
17
10
2021
revised:
01
04
2022
accepted:
25
04
2022
pubmed:
3
6
2022
medline:
17
8
2022
entrez:
2
6
2022
Statut:
ppublish
Résumé
The bacterial injectisome is a structurally conserved, syringe-shaped nanomachine that spans the Gram-negative envelope and forms a continuous channel for type III secretion of protein effectors. The injectisome, and the host-modulating effectors it secretes, are essential for the pathogenesis of several Gram-negative bacterial species, and it is a key virulence factor associated with the progression of many clinical and community-based infectious diseases. The molecular structure of the injectisome has been the focus of intense research efforts over the past 30 years, and during this time significant progress has been made in determining the molecular structures of many components. In this review we present major advances in our structural and mechanistic understanding of the injectisome, as facilitated by cryoelectron microscopy approaches.
Identifiants
pubmed: 35654690
pii: S0968-0004(22)00112-8
doi: 10.1016/j.tibs.2022.04.013
pii:
doi:
Substances chimiques
Bacterial Proteins
0
Virulence Factors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
795-809Informations de copyright
Crown Copyright © 2022. Published by Elsevier Ltd. All rights reserved.