Exercise, Mitohormesis, and Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c).
Exercise
Hormesis
MOTS-c peptide, human
Mitochondria
Mitochondrial proteins
Obesity
Journal
Diabetes & metabolism journal
ISSN: 2233-6087
Titre abrégé: Diabetes Metab J
Pays: Korea (South)
ID NLM: 101556588
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
21
03
2022
accepted:
27
04
2022
entrez:
3
6
2022
pubmed:
4
6
2022
medline:
7
6
2022
Statut:
ppublish
Résumé
Low levels of mitochondrial stress are beneficial for organismal health and survival through a process known as mitohormesis. Mitohormetic responses occur during or after exercise and may mediate some salutary effects of exercise on metabolism. Exercise-related mitohormesis involves reactive oxygen species production, mitochondrial unfolded protein response (UPRmt), and release of mitochondria-derived peptides (MDPs). MDPs are a group of small peptides encoded by mitochondrial DNA with beneficial metabolic effects. Among MDPs, mitochondrial ORF of the 12S rRNA type-c (MOTS-c) is the most associated with exercise. MOTS-c expression levels increase in skeletal muscles, systemic circulation, and the hypothalamus upon exercise. Systemic MOTS-c administration increases exercise performance by boosting skeletal muscle stress responses and by enhancing metabolic adaptation to exercise. Exogenous MOTS-c also stimulates thermogenesis in subcutaneous white adipose tissues, thereby enhancing energy expenditure and contributing to the anti-obesity effects of exercise training. This review briefly summarizes the mitohormetic mechanisms of exercise with an emphasis on MOTS-c.
Identifiants
pubmed: 35656563
pii: dmj.2022.0092
doi: 10.4093/dmj.2022.0092
pmc: PMC9171157
doi:
Substances chimiques
RNA, Ribosomal
0
RNA, ribosomal, 12S
0
Transcription Factors
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
402-413Subventions
Organisme : NCIRD CDC HHS
ID : H23 IP000855
Pays : United States
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