Event-based modeling in temporal lobe epilepsy demonstrates progressive atrophy from cross-sectional data.

Atrophy / pathology Biomarkers Cross-Sectional Studies Epilepsy / complications Epilepsy, Temporal Lobe / pathology Hippocampus / diagnostic imaging Humans Magnetic Resonance Imaging / methods Sclerosis / complications
MTLE disease progression duration of illness event-based model patient staging

Journal

Epilepsia
ISSN: 1528-1167
Titre abrégé: Epilepsia
Pays: United States
ID NLM: 2983306R

Informations de publication

Date de publication:
08 2022
Historique:
revised: 01 06 2022
received: 21 01 2022
accepted: 01 06 2022
pubmed: 4 6 2022
medline: 12 8 2022
entrez: 3 6 2022
Statut: ppublish

Résumé

Recent work has shown that people with common epilepsies have characteristic patterns of cortical thinning, and that these changes may be progressive over time. Leveraging a large multicenter cross-sectional cohort, we investigated whether regional morphometric changes occur in a sequential manner, and whether these changes in people with mesial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS) correlate with clinical features. We extracted regional measures of cortical thickness, surface area, and subcortical brain volumes from T1-weighted (T1W) magnetic resonance imaging (MRI) scans collected by the ENIGMA-Epilepsy consortium, comprising 804 people with MTLE-HS and 1625 healthy controls from 25 centers. Features with a moderate case-control effect size (Cohen d ≥ .5) were used to train an event-based model (EBM), which estimates a sequence of disease-specific biomarker changes from cross-sectional data and assigns a biomarker-based fine-grained disease stage to individual patients. We tested for associations between EBM disease stage and duration of epilepsy, age at onset, and antiseizure medicine (ASM) resistance. In MTLE-HS, decrease in ipsilateral hippocampal volume along with increased asymmetry in hippocampal volume was followed by reduced thickness in neocortical regions, reduction in ipsilateral thalamus volume, and finally, increase in ipsilateral lateral ventricle volume. EBM stage was correlated with duration of illness (Spearman ρ = .293, p = 7.03 × 10 From cross-sectional MRI, we reconstructed a disease progression model that highlights a sequence of MRI changes that aligns with previous longitudinal studies. This model could be used to stage MTLE-HS subjects in other cohorts and help establish connections between imaging-based progression staging and clinical features.

Identifiants

DOI: 10.1111/epi.17316 PMID: 35656586 PMC: PMC9540015
pubmed: 35656586
doi: 10.1111/epi.17316
pmc: PMC9540015
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Multicenter Study Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

2081-2095

Subventions

Organisme : Medical Research Council
ID : MR/M00841X/1
Pays : United Kingdom
Organisme : NIBIB NIH HHS
ID : R01 EB015611
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG058854
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS065838
Pays : United States
Organisme : Medical Research Council
ID : MR/L016311/1
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH117601
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG059874
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS120976
Pays : United States
Organisme : NIH HHS
ID : S10 OD023696
Pays : United States
Organisme : Medical Research Council
ID : MR/S03546X/1
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH116147
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015922
Pays : United States
Organisme : Medical Research Council
ID : MR/N026063/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S00355X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T04294X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K023152/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0802012
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K013998/1
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : RF1 MH123163
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS107739
Pays : United States

Investigateurs

Núria Bargalló (N)
Emanuele Bartolini (E)
Terence J O'Brien (TJ)
Rhys H Thomas (RH)

Informations de copyright

© 2022 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.

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Auteurs

Seymour M Lopez (SM)

Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK.

Leon M Aksman (LM)

Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Neil P Oxtoby (NP)

Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK.

Sjoerd B Vos (SB)

Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, UK.
ORCID: 0000-0002-8502-4487

Jun Rao (J)

Department of Psychiatry, University of California, San Diego, La Jolla, California, USA.

Erik Kaestner (E)

Department of Psychiatry, University of California, San Diego, La Jolla, California, USA.
ORCID: 0000-0003-3252-5365

Saud Alhusaini (S)

Department of Neurology, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.

Marina Alvim (M)

Department of Neurology and Neuroimaging Laboratory, University of Campinas, Campinas, Brazil.
ORCID: 0000-0002-6780-0761

Benjamin Bender (B)

Department of Radiology, Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany.

Andrea Bernasconi (A)

Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
ORCID: 0000-0001-9358-5703

Neda Bernasconi (N)

Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
ORCID: 0000-0002-8947-9518

Boris Bernhardt (B)

Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
ORCID: 0000-0001-9256-6041

Leonardo Bonilha (L)

Department of Neurology, Emory University, Atlanta, USA.

Lorenzo Caciagli (L)

Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK.

Benoit Caldairou (B)

Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

Maria Eugenia Caligiuri (ME)

Neuroscience Research Center, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
ORCID: 0000-0002-2030-5552

Angels Calvet (A)

Magnetic Resonance Image Core Facility, August Pi i Sunyer Biomedical Research Institute, University of Barcelona, Barcelona, Spain.

Fernando Cendes (F)

Department of Neurology and Neuroimaging Laboratory, University of Campinas, Campinas, Brazil.
ORCID: 0000-0001-9336-9568

Luis Concha (L)

Institute of Neurobiology, National Autonomous University of Mexico, Querétaro, Mexico.
ORCID: 0000-0002-7842-3869

Estefania Conde-Blanco (E)

Epilepsy Program, Neurology Department, Hospital Clinic of Barcelona, Barcelona, Spain.
August Pi i Sunyer Biomedical Research Institute, Barcelona, Spain.
ORCID: 0000-0001-7436-987X

Esmaeil Davoodi-Bojd (E)

Radiology and Research Administration, Henry Ford Health System, Detroit, Michigan, USA.

Christophe de Bézenac (C)

Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
ORCID: 0000-0002-2433-9776

Norman Delanty (N)

Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
FutureNeuro SFI Research Centre for Rare and Chronic Neurological Diseases, Dublin, Ireland.
ORCID: 0000-0002-3953-9842

Patricia M Desmond (PM)

Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia.

Orrin Devinsky (O)

New York University Grossman School of Medicine, New York, New York, USA.
ORCID: 0000-0003-0044-4632

Martin Domin (M)

Functional Imaging Unit, Department of Diagnostic Radiology and Neuroradiology, Greifswald University Medicine, Greifswald, Germany.

John S Duncan (JS)

Department of Neurology, Emory University, Atlanta, USA.
Chalfont Centre for Epilepsy, Chalfont St Peter, UK.

Niels K Focke (NK)

Department of Neurology, University Medical Center, Göttingen, Germany.
ORCID: 0000-0001-5486-6289

Sonya Foley (S)

Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK.

Francesco Fortunato (F)

Institute of Neurology, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
ORCID: 0000-0001-8395-7809

Marian Galovic (M)

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK.
Department of Neurology, University Hospital Zurich, Zurich, Switzerland.

Antonio Gambardella (A)

Neuroscience Research Center, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Institute of Neurology, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
ORCID: 0000-0001-7384-3074

Ezequiel Gleichgerrcht (E)

Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA.
ORCID: 0000-0002-4212-4146

Renzo Guerrini (R)

Neuroscience Department, University of Florence, Florence, Italy.
ORCID: 0000-0002-7272-7079

Khalid Hamandi (K)

Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK.
Wales Epilepsy Unit, Department of Neurology, University Hospital of Wales, Cardiff, UK.

Victoria Ives-Deliperi (V)

Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
ORCID: 0000-0003-2640-249X

Graeme D Jackson (GD)

Florey Institute of Neuroscience and Mental Health, Austin Campus, Heidelberg, Victoria, Australia.
University of Melbourne, Parkville, Victoria, Australia.
Department of Neurology, Austin Health, Heidelberg, Victoria, Australia.

Neda Jahanshad (N)

Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.

Simon S Keller (SS)

Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
ORCID: 0000-0001-5247-9795

Peter Kochunov (P)

Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Raviteja Kotikalapudi (R)

Department of Radiology, Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany.
Department of Clinical Neurophysiology, University Hospital Göttingen, Göttingen, Germany.
Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

Barbara A K Kreilkamp (BAK)

Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Clinical Neurophysiology, University Medical Center Göttingen, Göttingen, Germany.

Angelo Labate (A)

Neuroscience Research Center, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Institute of Neurology, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
ORCID: 0000-0002-8827-7324

Sara Larivière (S)

Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
ORCID: 0000-0001-5701-1307

Matteo Lenge (M)

Pediatric Neurology, Neurogenetics and Neurobiology Unit and Laboratories, A. Meyer Children's Hospital, University of Florence, Florence, Italy.
Functional and Epilepsy Neurosurgery Unit, Neurosurgery Department, A. Meyer Children's Hospital, University of Florence, Florence, Italy.

Elaine Lui (E)

Department of Radiology, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia.

Charles Malpas (C)

Department of Neurology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.
ORCID: 0000-0003-0534-3718

Pascal Martin (P)

Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Mario Mascalchi (M)

Mario Serio Department of Clinical and Experimental Medical Sciences, University of Florence, Florence, Italy.

Sarah E Medland (SE)

Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Stefano Meletti (S)

Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Neurology Unit, OCB Hospital, Modena University Hospital, Modena, Italy.
ORCID: 0000-0003-0334-539X

Marcia E Morita-Sherman (ME)

Department of Neurology, University of Campinas, Campinas, Brazil.
Cleveland Clinic Neurological Institute, Cleveland, Ohio, USA.
ORCID: 0000-0002-8531-3916

Thomas W Owen (TW)

School of Computing, Newcastle University, Newcastle Upon Tyne, UK.

Mark Richardson (M)

Division of Neuroscience, King's College London, London, UK.

Antonella Riva (A)

Giannina Gaslini Institute, Scientific Institute for Research and Health Care, Genoa, Italy.
Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.
ORCID: 0000-0001-9152-5571

Theodor Rüber (T)

Department of Epileptology, University Hospital Bonn, Bonn, Germany.
ORCID: 0000-0002-6180-7671

Ben Sinclair (B)

Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.
Departments of Medicine and Radiology, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.
ORCID: 0000-0002-0850-3644

Hamid Soltanian-Zadeh (H)

Radiology and Research Administration, Henry Ford Health System, Detroit, Michigan, USA.
School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran.

Dan J Stein (DJ)

SA MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.

Pasquale Striano (P)

Giannina Gaslini Institute, Scientific Institute for Research and Health Care, Genoa, Italy.
Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy.
ORCID: 0000-0002-6065-1476

Peter N Taylor (PN)

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK.
School of Computing, Newcastle University, Newcastle Upon Tyne, UK.
ORCID: 0000-0003-2144-9838

Sophia I Thomopoulos (SI)

Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.

Paul M Thompson (PM)

Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.

Manuela Tondelli (M)

Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Primary Care Department, Local Health Authority of Modena, Modena, Italy.
ORCID: 0000-0001-6698-5437

Anna Elisabetta Vaudano (AE)

Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Neurology Unit, OCB Hospital, Modena University Hospital, Modena, Italy.
ORCID: 0000-0002-6280-7526

Lucy Vivash (L)

Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.
Departments of Medicine and Radiology, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.
ORCID: 0000-0002-1182-0907

Yujiang Wang (Y)

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK.
School of Computing, Newcastle University, Newcastle Upon Tyne, UK.

Bernd Weber (B)

Institute of Experimental Epileptology and Cognition Research, University of Bonn, Bonn, Germany.

Christopher D Whelan (CD)

Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.

Roland Wiest (R)

Support Center for Advanced Neuroimaging, University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Gavin P Winston (GP)

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK.
Chalfont Centre for Epilepsy, Chalfont St Peter, UK.
Department of Medicine, Division of Neurology, Queen's University, Kingston, Ontario, Canada.
ORCID: 0000-0001-9395-1478

Clarissa Lin Yasuda (CL)

Department of Neurology and Neuroimaging Laboratory, University of Campinas, Campinas, Brazil.

Carrie R McDonald (CR)

Department of Psychiatry, University of California, San Diego, La Jolla, California, USA.

Daniel C Alexander (DC)

Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK.

Sanjay M Sisodiya (SM)

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, London, UK.
Chalfont Centre for Epilepsy, Chalfont St Peter, UK.
ORCID: 0000-0002-1511-5893

Andre Altmann (A)

Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, UK.
ORCID: 0000-0002-9265-2393

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Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Atrophie › Event-based modeling in temporal lobe epilepsy...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Event-based modeling in temporal lobe epilepsy...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Event-based modeling in temporal lobe epilepsy...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Épilepsie › Event-based modeling in temporal lobe epilepsy...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Épilepsie › Syndromes épileptiques › Épilepsie temporale › Event-based modeling in temporal lobe epilepsy...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Event-based modeling in temporal lobe epilepsy...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Event-based modeling in temporal lobe epilepsy...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Event-based modeling in temporal lobe epilepsy...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Sclérose › Event-based modeling in temporal lobe epilepsy...