Germ cell tumors with neuroglial differentiation do not show molecular features akin to their central nervous system counterpart: experience from extra-gynecological sites.
Astrocytoma
/ genetics
Brain Neoplasms
/ genetics
Central Nervous System
/ pathology
Central Nervous System Neoplasms
/ genetics
Female
Glioma
/ genetics
Homozygote
Humans
In Situ Hybridization, Fluorescence
Neoplasms, Germ Cell and Embryonal
/ genetics
Neoplasms, Neuroepithelial
/ genetics
Sequence Deletion
Teratoma
/ genetics
Embryonal tumor with multilayered rosettes
Germ cell tumor
Immunohistochemistry
Neuroepithelial tumor
Teratoma
Journal
Virchows Archiv : an international journal of pathology
ISSN: 1432-2307
Titre abrégé: Virchows Arch
Pays: Germany
ID NLM: 9423843
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
26
11
2021
accepted:
30
05
2022
revised:
06
05
2022
pubmed:
10
6
2022
medline:
4
8
2022
entrez:
9
6
2022
Statut:
ppublish
Résumé
Teratomas with secondary somatic malignancy showing neuroglial differentiation (central nervous system (CNS)-type tumors) arising from a glial or neuroepithelial component is a very uncommon event and primarily described in the ovary. We aimed to describe the morphological spectrum and molecular features of CNS type of neuroepithelial tumors arising from the germ cell tumors (GCT) in the extra-gynecological sites. All cases of teratoma and mixed GCT arising from the non-gynecological sites over 7 years were screened for CNS type of neuroepithelial tumors. Detailed histological and immunohistochemical analysis was performed. IDH1 and 2 sequencings were performed in the glial tumors. Fluorescent in situ hybridization (FISH) was performed for EWSR1 rearrangement, 19/19q co-deletion, CDKN2A homozygous deletion, EGFR amplification, and C19MC amplification, wherever required. Out of 302 GCTs examined, the neuroglial tumor was detected in 15 cases. It included nine cases of glial tumors (including one pilocytic astrocytoma (grade I), two diffuse astrocytomas (grade II), one oligodendroglioma (grade II), one gemistocytic astrocytoma (grade II), three anaplastic astrocytomas (grade III), and one case of glioblastoma (grade IV)) and six cases of the embryonal tumor with multilayered rosettes (ETMR). None of the gliomas showed IDH mutation by immunohistochemistry or sequencing. The ETMR cases did not show Lin28 expression or C19MC amplification. To conclude, the spectrum of neuroglial tumors arising from teratoma in the extragonadal sites is vast and most commonly includes glial neoplasms and embryonal tumors. Our findings indicate that the genotype and pathogenesis of tumors with neuroglial differentiation in teratoma are distinct from their CNS counterpart.
Identifiants
pubmed: 35678876
doi: 10.1007/s00428-022-03354-z
pii: 10.1007/s00428-022-03354-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
213-221Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Ulbright TM, Loehrer PJ, Roth LM et al (1984) The development of non-germ cell malignancies within germ cell tumors. A clinicopathologic study of 11 cases. Cancer 54:1824–1833
doi: 10.1002/1097-0142(19841101)54:9<1824::AID-CNCR2820540910>3.0.CO;2-J
Malagon HD, Valdez AM, Moran CA et al (2007) Germ cell tumors with sarcomatous components: a clinicopathologic and immunohistochemical study of 46 cases. Am J Surg Pathol 31:1356–1362
doi: 10.1097/PAS.0b013e318033c7c4
Colecchia M, Necchi A, Paolini B et al (2011) Teratoma with somatic type malignant components in germ cell tumors of the testis: a clinicopathologic analysis of 40 cases with outcome correlation. Int J Surg Pathol 19:321–327
doi: 10.1177/1066896910390680
Magers MJ, Kao CS, Cole CD et al (2014) “Somatic-type” malignancies arising from testicular germ cell tumors: a clinicopathologic study of 124 cases with emphasis on glandular tumors supporting frequent yolk sac tumor origin. Am J Surg Pathol 38:1396–1409
doi: 10.1097/PAS.0000000000000262
Trabzonlu L, Durmaz G, Vural C, Muezzinoglu B, Corakci A (2017) Malignant tumors associated with ovarian mature teratoma: a single institution experience. Pathol Res Pract 213:518–521
doi: 10.1016/j.prp.2017.01.016
Chiang S, Snuderl M, Kojiro-Sanada S et al (2017) Primitive neuroectodermal tumors of the female genital tract: a morphologic, immunohistochemical, and molecular study of 19 cases. Am J Surg Pathol 41:761–772
doi: 10.1097/PAS.0000000000000831
Murdock T, Orr B, Allen S et al (2018) Central nervous system-type neuroepithelial tumors and tumor-like proliferations developing in the gynecologic tract and pelvis: clinicopathologic analysis of 23 cases. Am J Surg Pathol 42:1429–1444
doi: 10.1097/PAS.0000000000001131
Matoso A, Idrees MT, Rodriguez FJ et al (2019) Neuroglial differentiation and neoplasms in testicular germ cell tumors lack immunohistochemical evidence of alterations characteristic of their CNS counterparts: a study of 13 cases. Am J Surg Pathol 43:422–431
doi: 10.1097/PAS.0000000000001206
Ulbright TM, Hattab EM, Zhang S et al (2010) Primitive neuroectodermal tumors in patients with testicular germ cell tumors usually resemble pediatric-type central nervous system embryonal neoplasms and lack chromosome 22 rearrangements. Mod Pathol 23:972–980
doi: 10.1038/modpathol.2010.70
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (2016) World Health Organization Histological Classification of Tumours of the Central Nervous System. International Agency for Research on Cancer, Lyon, France.
Chatterjee D, Radotra BD, Kumar N, Vasishta RK, Gupta SK (2018) IDH1, ATRX, and BRAFV600E mutation in astrocytic tumors and their significance in patient outcome in north Indian population. Surg Neurol Int 9:29
doi: 10.4103/sni.sni_284_17
Liu L, Jentoft ME, Boland JM (2016) Glioblastoma arising within a mediastinal mature teratoma. Hum Pathol 56:109–113
doi: 10.1016/j.humpath.2016.05.019
Jung CK, Lee YS, Jung ES et al (2002) Oligodendroglioma arising in a sacrococcygeal immature teratoma. J Korean Med Sci 17:426–428
doi: 10.3346/jkms.2002.17.3.426
Longano A, Conyers R (2010) Medulloblastoma arising from intracranial immature teratoma. Pathology 42:102–104
doi: 10.3109/00313020903434728
Moch H, Humphrey PA, Ulbright TM, et al (2016) World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs. International Agency for Research on Cancer, Lyon, France.
Krouwer HG, Davis RL, Silver P, Prados M (1991) Gemistocytic astrocytomas: a reappraisal. J Neurosurg 74:399–406
doi: 10.3171/jns.1991.74.3.0399
Pearson M, Sylvia Kocialkowski L, Bäcklund M, Chan R, Jones DTW, Peter Collins V (2009) IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas. Neuro Oncol 11:341–347
doi: 10.1215/15228517-2009-025
Yan H, Parsons DW, Jin G et al (2009) IDH1 and IDH2 mutations in gliomas. N Engl J Med 360:765–773
doi: 10.1056/NEJMoa0808710
Korshunov A, Ryzhova M, Jones DT et al (2012) LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR). Acta Neuropathol 124:875–881
doi: 10.1007/s00401-012-1068-3
Euscher ED, Deavers MT, Lopez-Terrada D et al (2008) Uterine tumors with neuroectodermal differentiation: a series of 17 cases and review of the literature. Am J Surg Pathol 32:219–228
doi: 10.1097/PAS.0b013e318093e421
Murati Amador B, Matoso A (2019) Testicular germ cell tumor showing concurrent PNET and neuroglial neoplasms with wide spectrum of grades. Am J Surg Pathol 43:865–867
doi: 10.1097/PAS.0000000000001248
Magers MJ, Perrino CM, Ulbright TM, Idrees MT (2021) Immunophenotypic characterization of germ cell tumor-derived primitive neuroectodermal tumors: evidence for frequent neuronal and/or glial differentiation. Arch Pathol Lab Med 145:953–959
doi: 10.5858/arpa.2020-0352-OA
Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F, eds (2013) WHO Classification of Tumours: Soft Tissue and Bone Tumours, 4
Flood TA, Ulbright TM, Hirsch MS (2021) “Embryonic-type neuroectodermal tumor” should replace “primitive neuroectodermal tumor” of the testis and gynecologic tract: a rationale for new nomenclature. Am J Surg Pathol 45:1299–1302
doi: 10.1097/PAS.0000000000001703