Mortality in Cases of Acute Alcohol Intoxication in Children: A 10-Year Retrospective Study of the Moscow Region, Russia.


Journal

The American journal of forensic medicine and pathology
ISSN: 1533-404X
Titre abrégé: Am J Forensic Med Pathol
Pays: United States
ID NLM: 8108948

Informations de publication

Date de publication:
01 Sep 2022
Historique:
pubmed: 10 6 2022
medline: 17 8 2022
entrez: 9 6 2022
Statut: ppublish

Résumé

Russia suffers from high alcohol-related mortality. Most forensic autopsies in Russia include blood alcohol tests, but a systematic analysis of these data has never been conducted for children's deaths. We performed an analysis of juvenile mortality using autopsy reports from the Moscow Region Bureau of Forensic Medical Examination from January 1, 2009, to December 31, 2018. Despite a decrease in incidence ( Rs = -0.661), the number of cases of alcohol intoxication in minors was still high. The mean age of children in our study was 14.77 years (95% confidence interval [CI], 14.31-15.23). Death was predominantly among boys (72%) and those with higher blood alcohol concentrations (mean difference [MD], 0.295; 95% CI MD , 0.012-0.58). The number of cases of unnatural death increased with age ( Rs = 0.746, P = 0.001). Accidents were the most predominant cause of death, followed by suicide, homicide, and natural causes. Fatal alcohol intoxication was observed at an average blood alcohol concentration of 3.58 g/L (95% CI, 1.46-5.7), without any specific signs on autopsy. Even a strong smell of alcohol is an unreliable sign in the clinic. A systematic study of alcohol in forensic autopsy shows that the number of children who die with alcohol intoxication is high. Teenagers are the predominant age group experiencing alcohol intoxication. In our opinion, an alcohol blood test should be performed in all suspicious cases, especially in teenagers.

Sections du résumé

BACKGROUND BACKGROUND
Russia suffers from high alcohol-related mortality. Most forensic autopsies in Russia include blood alcohol tests, but a systematic analysis of these data has never been conducted for children's deaths.
METHODS METHODS
We performed an analysis of juvenile mortality using autopsy reports from the Moscow Region Bureau of Forensic Medical Examination from January 1, 2009, to December 31, 2018.
RESULTS RESULTS
Despite a decrease in incidence ( Rs = -0.661), the number of cases of alcohol intoxication in minors was still high. The mean age of children in our study was 14.77 years (95% confidence interval [CI], 14.31-15.23). Death was predominantly among boys (72%) and those with higher blood alcohol concentrations (mean difference [MD], 0.295; 95% CI MD , 0.012-0.58). The number of cases of unnatural death increased with age ( Rs = 0.746, P = 0.001). Accidents were the most predominant cause of death, followed by suicide, homicide, and natural causes. Fatal alcohol intoxication was observed at an average blood alcohol concentration of 3.58 g/L (95% CI, 1.46-5.7), without any specific signs on autopsy. Even a strong smell of alcohol is an unreliable sign in the clinic.
CONCLUSION CONCLUSIONS
A systematic study of alcohol in forensic autopsy shows that the number of children who die with alcohol intoxication is high. Teenagers are the predominant age group experiencing alcohol intoxication. In our opinion, an alcohol blood test should be performed in all suspicious cases, especially in teenagers.

Identifiants

pubmed: 35679160
doi: 10.1097/PAF.0000000000000764
pii: 00000433-202209000-00005
doi:

Substances chimiques

Blood Alcohol Content 0
Ethanol 3K9958V90M

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

231-235

Informations de copyright

Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

Déclaration de conflit d'intérêts

The authors report no conflict of interest.

Références

World Health Organization. Management of Substance Abuse Team. Global Status Report on Alcohol and Health . Geneva, Switzerland: World Health Organization; 2009.
Tõnisson M, Tillmann V, Kuudeberg A, et al. Acute alcohol intoxication characteristics in children. Alcohol Alcohol . 2013;48:390–395.
Lamminpää A, Vilska J. Acute alcohol intoxications in children treated in hospital. Acta Paediatr . 1990;79:847–854.
de Veld L, van Hoof JJ, Ouwehand S, et al. Age at first alcohol use as a possible risk factor for adolescent acute alcohol intoxication hospital admission in the Netherlands. Alcohol Clin Exp Res . 2020;44:219–224.
Van Zanten E, Van der Ploeg T, Van Hoof JJ, et al. Gender, age, and educational level attribute to blood alcohol concentration in hospitalized intoxicated adolescents; a cohort study. Alcohol Clin Exp Res . 2013;37:1188–1194.
Buzik OZ, Koshkina EA, Egorov VF, et al. Monitoring Potrebleniya Psihoaktivnyh Veshchestv v Moskve v 2014–2018 Godah . Moscow, Russia: Moscow Healthcare Department; 2019.
Vasiliev V, Ostapenko Y, Livanov A, et al. Alcohol poisoning in adolescence. In: Lodyagin AN, Sofronov AG, eds. Problems of narco-toxicology: from toxicology intensive care unit to drug rehabilitation . Saint Petersburg: Alta Astra; 2016:18–18.
Klevno VA, Ostapenko YN, Maksimov AV. Clinical toxicology and forensic aspects of the evaluation of the toxic effect of ethanol in children. Toxicol Rev . 2018;152:3–8.
Vonghia L, Leggio L, Ferrulli A, et al. Acute alcohol intoxication. Eur J Intern Med . 2008;19:561–567.
Amberg R, Madea B, Thomsen JL, et al. Special issues regarding expert evidence in violent death. In: Madea B, ed. Handbook of Forensic Medicine . University of Bonn, Bonn, Germany: Institute of Forensic Medicine; 2014:562–595.
Zaitsu M, Inada Y, Tashiro K, et al. Acute alcohol intoxication in a 15-day-old neonate. Pediatr Int . 2013;55:792–794.
Lee D, Harwayne-Gidansky I. A 3-month-old infant with lethargy and metabolic acidosis. Clin Pediatr . 2017;56:798–800.
McCormick T, Levine M, Knox O, et al. Ethanol ingestion in two infants under 2 months old: a previously unreported cause of ALTE. Pediatrics . 2013;131:e604–e607.
Boroughf WJ, Nelson LS, Henretig FM. Case studies in toxicology: babies and booze—pediatric considerations in the management of ethanol intoxication a 4-month-old infant was brought to the ED by her father after a reported unintentional ethanol exposure. Emerg Med . 2015;47:272–274.
Wu C-T, Hsia S-H, Chen C-L, et al. Acute fatal alcohol intoxication in a 3-day-old neonate. Pediatr Neonatol . 2017;58:278–280.
Okoye CN, Okoye MI. Forensic epidemiology of childhood deaths in Nebraska, USA. J Forensic Leg Med . 2011;18:366–374.
Fraga AMA, Fraga GP, Stanley C, et al. Children at danger: injury fatalities among children in San Diego County. Eur J Epidemiol . 2010;25:211–217.
Sekii H, Ohtsu T, Shirasawa T, et al. Childhood mortality due to unintentional injuries in Japan, 2000–2009. Int J Environ Res Public Health . 2013;10:528–540.
Mosek DP, Sperhake JP, Edler C, et al. Cases of asphyxia in children and adolescents: a retrospective analysis of fatal accidents, suicides, and homicides from 1998 to 2017 in Hamburg, Germany. Int J Leg Med . 2020;134:1073–1081.
Lamminpaa A, Vilska J, Korri UM, et al. Alcohol intoxication in hospitalized young teenagers. Acta Paediatr . 1993;82:783–788.
Bouthoorn SH, van der Ploeg T, van Erkel NE, et al. Alcohol intoxication among Dutch adolescents: acute medical complications in the years 2000–2010. Clin Pediatr (Phila) . 2011;50:244–251.
Grüne B, Piontek D, Pogarell O, et al. Acute alcohol intoxication among adolescents—the role of the context of drinking. Eur J Pediatr . 2017;176:31–39.
Trefan L, Gartner A, Alcock A, et al. Epidemiology of alcohol-related emergency hospital admissions in children and adolescents: an e-cohort analysis in Wales in 2006–2011. PLoS One . 2019;14:e0217598.
Vrkic Boban I, Vrca A, Saraga M. Changing pattern of acute alcohol intoxications in children. Med Sci Monit . 2018;24:5123–5131.
Ringmets I, Tuusov J, Lang K, et al. Alcohol and premature death in Estonian men: a study of forensic autopsies using novel biomarkers and proxy informants. BMC Public Health . 2012;12:146.
Straka L, Zubor P, Novomesky F, et al. Fatal alcohol intoxication in women: a forensic autopsy study from Slovakia. BMC Public Health . 2011;11:924.
VAP EN Travenko. Pathological signs of ethanol poisoning in the diagnosis of the onset of death mechanisms. J Forensic Med . 2016;5:28–30.

Auteurs

Semyon S Plis (SS)

From the Department of Forensic Medicine, Moscow Regional Research and Clinical Institute ("MONIKI").

Vladimir A Klevno (VA)

From the Department of Forensic Medicine, Moscow Regional Research and Clinical Institute ("MONIKI").

Vasiliy V Vlassov (VV)

Department of Health Care Management and Economics, National Research University Higher School of Economics, Moscow, Russia.

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