Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan.
1,2,4-triazole
1,3,4-thiadiazole
TDP1 inhibitors
adamantane
monoterpene
synergy
tyrosyl-DNA phosphodiesterase 1
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
24 May 2022
24 May 2022
Historique:
received:
29
04
2022
revised:
15
05
2022
accepted:
22
05
2022
entrez:
10
6
2022
pubmed:
11
6
2022
medline:
14
6
2022
Statut:
epublish
Résumé
Inhibiting tyrosyl-DNA phosphodiesterase 1 (TDP1) is a promising strategy for increasing the effectiveness of existing antitumor therapy since it can remove the DNA lesions caused by anticancer drugs, which form covalent complexes with topoisomerase 1 (TOP1). Here, new adamantane-monoterpene conjugates with a 1,2,4-triazole or 1,3,4-thiadiazole linker core were synthesized, where (+)-and (-)-campholenic and (+)-camphor derivatives were used as monoterpene fragments. The campholenic derivatives
Identifiants
pubmed: 35684313
pii: molecules27113374
doi: 10.3390/molecules27113374
pmc: PMC9182348
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Monoterpenes
0
Phosphodiesterase Inhibitors
0
Camphor
76-22-2
Topotecan
7M7YKX2N15
Phosphoric Diester Hydrolases
EC 3.1.4.-
Adamantane
PJY633525U
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Russian Science Foundation
ID : 19-13-00040
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