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Composés hétérocycliques
Alcaloïdes
Camptothécine
Topotécane
Topotécane : Questions médicales fréquentes
Diagnostic
2
Topotécan
Cancer
Diagnostic médical
Tests de laboratoire
Imagerie médicale
Topotécan
Symptômes
2
Effets secondaires
Topotécan
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Douleur
Topotécan
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2
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Topotécan
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2
Administration de médicaments
Topotécan
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2
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2
Facteurs de risque
Topotécan
Antécédents médicaux
Personnes âgées
Topotécan
Surveillance médicale
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Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 26/08/2026
Contenu vérifié selon les dernières recommandations médicales
4 publications dans cette catégorie
Affiliations :
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Publications dans "Topotécane" :
4 publications dans cette catégorie
Affiliations :
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
V. Zelman Institute for the Medicine and Psychology, Novosibirsk State University, 630090 Novosibirsk, Russia.
Publications dans "Topotécane" :
4 publications dans cette catégorie
Affiliations :
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Publications dans "Topotécane" :
4 publications dans cette catégorie
Affiliations :
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Publications dans "Topotécane" :
3 publications dans cette catégorie
Affiliations :
Ophthalmic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Department of Ophthalmology, Weill Cornell Medical College, New York, New York, USA.
Publications dans "Topotécane" :
3 publications dans cette catégorie
Affiliations :
Ophthalmic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Department of Ophthalmology, Weill Cornell Medical College, New York, New York, USA.
Publications dans "Topotécane" :
3 publications dans cette catégorie
Affiliations :
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Publications dans "Topotécane" :
3 publications dans cette catégorie
Affiliations :
Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, 162 06 Prague, Czech Republic.
Publications dans "Topotécane" :
3 publications dans cette catégorie
Affiliations :
Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, 162 06 Prague, Czech Republic.
Publications dans "Topotécane" :
3 publications dans cette catégorie
Affiliations :
Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, 162 06 Prague, Czech Republic.
Publications dans "Topotécane" :
3 publications dans cette catégorie
Affiliations :
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9, Akademika Lavrentieva Ave., 630090 Novosibirsk, Russia.
Publications dans "Topotécane" :
3 publications dans cette catégorie
Affiliations :
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Publications dans "Topotécane" :
3 publications dans cette catégorie
Affiliations :
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia. lavrik@niboch.nsc.ru.
Publications dans "Topotécane" :
2 publications dans cette catégorie
Affiliations :
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Publications dans "Topotécane" :
2 publications dans cette catégorie
Affiliations :
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
V. Zelman Institute for the Medicine and Psychology, Novosibirsk State University, 630090 Novosibirsk, Russia.
Publications dans "Topotécane" :
2 publications dans cette catégorie
Affiliations :
Department of Cell Biology and Pathology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Publications dans "Topotécane" :
2 publications dans cette catégorie
Affiliations :
Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA.
Publications dans "Topotécane" :
2 publications dans cette catégorie
Affiliations :
College of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, Republic of Korea.
Publications dans "Topotécane" :
2 publications dans cette catégorie
Affiliations :
College of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, Republic of Korea.
Publications dans "Topotécane" :
2 publications dans cette catégorie
Affiliations :
College of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, Republic of Korea. Electronic address: leeyb@chonnam.ac.kr.
Publications dans "Topotécane" :
The primary limiting factor in achieving cures for patients with cancer, particularly ovarian cancer, is drug resistance. The mechanisms of drug resistance of cancer cells during chemotherapy may incl...
In this study, we conducted a detailed analysis of TGFBI expression in different ovarian cancer cell lines (A2780, A2780TR1, A2780TR2, W1, W1TR, SKOV-3, PEA1, PEA2 and PEO23). The level of TGFBI mRNA ...
We observed upregulation of TGFBI mRNA in drug-resistant cell lines and estrogen-receptor positive cell lines, which was supported by overexpression of both intracellular and extracellular TGFBI prote...
The expression of TGFBI in ovarian cancer cell lines suggests its role in the development of drug resistance....
In this work, UiO-66-NH...
Acute myeloid leukemia (AML) is a common type of acute leukemia in adults and relapse is one of the main reasons for treatment failure. FLT3‑ITD mutations are associated with poor prognosis, short dis...
Gold nanomaterials have been widely explored in electrochemical sensors due to their high catalytic property and good stability in multi-medium. In this paper, the reproducibility of the signal among ...
Synthetic data may proxy clinical data. At the absence of direct clinical data, this study aimed to compare Irinotecan and Ifosfamide (II) with Topotecan in synthetic, recurrent small cell lung cancer...
Two simulation stages were conducted. Initially, 200 recurrent SCLC cases were simulated to replicate a previous phase 3 trial, testing the utility of Cox proportional hazards model and simulation met...
CAV versus Topotecan comparison showed no statistical difference in overall survival (hazard ratio (HR): 0.89, 95% CI: 0.67-1.18, P = 0.418), aligning with the original clinical trial. For the Topotec...
Artificial trial results for CAV versus Topotecan matched the original trial, confirming indifference of OAS. Additionally, II yielded superior overall survival compared to Topotecan in recurrent SCLC...
Patients with relapsed small cell lung cancer (SCLC), a high replication stress tumor, have poor prognoses and few therapeutic options. A phase 2 study showed antitumor activity with the addition of t...
To investigate whether the addition of berzosertib to topotecan improves clinical outcomes for patients with relapsed SCLC....
Between December 1, 2019, and December 31, 2022, this open-label phase 2 randomized clinical trial recruited 60 patients with SCLC and relapse after 1 or more prior therapies from 16 US cancer centers...
Eligible patients were randomly assigned to receive topotecan alone (group 1), 1.25 mg/m2 intravenously on days 1 through 5, or with berzosertib (group 2), 210 mg/m2 intravenously on days 2 and 5, in ...
The primary end point was progression-free survival (PFS) in the intention-to-treat population. Secondary end points included overall survival (OS) in the overall population and among patients with pl...
Of 60 patients (median [range] age, 59 [34-79] years; 33 [55%] male) included in this study, 20 were randomly assigned to receive topotecan alone and 40 to receive a combination of topotecan with berz...
In this randomized clinical trial, treatment with berzosertib plus topotecan did not improve PFS compared with topotecan therapy alone among patients with relapsed SCLC. However, the combination treat...
ClinicalTrials.gov Identifier: NCT03896503....
The increase in cancer diagnoses and cancer deaths, severe side effects of existing treatments and resistance to traditional treatments have generated a need for new anticancer treatments. Glioblastom...
In patients with relapsed or refractory neuroblastoma (NB), the limited efficacy of conventional chemotherapies necessitates the exploration of new treatment options. Previous studies have highlighted...
This report focuses on lurbinectedin activity and safety in a subgroup of small cell lung cancer (SCLC) patients from a Basket phase 2 study (Trigo et al. Lancet Oncology 2020;21:645-654) with chemoth...
Patients with extensive-stage SCLC, no central nervous system (CNS) metastases, and disease progression after platinum-containing therapy were included. Topotecan data from a contemporary, randomized,...
Lurbinectedin showed a statistically significant higher overall response rate (ORR) by investigator assessment (IA) compared to topotecan subgroup (41.0 % vs. 25.5 %; p = 0.0382); higher ORR by Indepe...
With the limitations of an indirect comparison, however using recent and comparable SCLC datasets, this post hoc analysis shows that SCLC patients with CTFI ≥ 30 days and no CNS metastases have a posi...
P-glycoprotein (Pgp) plays a pivotal role in drug bioavailability and multi-drug resistance development. Understanding the protein's activity and designing effective drugs require insight into the mec...