Titre : Topotécane

Topotécane : Questions médicales fréquentes

Questions fréquentes et termes MeSH associés

Diagnostic 2

#1

Comment le topotécane est-il utilisé dans le diagnostic ?

Le topotécane n'est pas utilisé pour le diagnostic, mais pour traiter des cancers diagnostiqués.
Topotécan Cancer Diagnostic médical
#2

Quels tests précèdent l'administration de topotécane ?

Des tests sanguins et d'imagerie sont effectués pour évaluer la santé du patient et la progression du cancer.
Tests de laboratoire Imagerie médicale Topotécan

Symptômes 2

#1

Quels sont les effets secondaires du topotécane ?

Les effets secondaires incluent nausées, vomissements, fatigue, et baisse des globules blancs.
Effets secondaires Topotécan Nausées
#2

Le topotécane cause-t-il des douleurs ?

Il peut provoquer des douleurs abdominales ou musculaires, mais ce n'est pas systématique.
Douleur Topotécan Effets indésirables

Prévention 2

#1

Peut-on prévenir les effets secondaires du topotécane ?

Des médicaments antiémétiques peuvent être prescrits pour prévenir les nausées et vomissements.
Prévention Topotécan Médicaments antiémétiques
#2

Y a-t-il des mesures préventives avant le traitement ?

Une évaluation médicale complète est nécessaire pour identifier les risques avant le traitement.
Évaluation médicale Topotécan Prévention des risques

Traitements 2

#1

Comment le topotécane est-il administré ?

Le topotécane est généralement administré par voie intraveineuse ou orale, selon le protocole.
Administration de médicaments Topotécan Voie intraveineuse
#2

Avec quels autres traitements le topotécane est-il combiné ?

Il est souvent combiné avec d'autres chimiothérapies ou thérapies ciblées pour améliorer l'efficacité.
Chimiothérapie Topotécan Thérapies combinées

Complications 2

#1

Quelles complications peuvent survenir avec le topotécane ?

Des complications comme l'infection, l'anémie et des réactions allergiques peuvent survenir.
Complications Topotécan Infection
#2

Comment gérer les complications du topotécane ?

La gestion inclut des soins de soutien, des transfusions sanguines et des antibiotiques si nécessaire.
Gestion des complications Topotécan Soins de soutien

Facteurs de risque 2

#1

Qui est à risque d'effets indésirables du topotécane ?

Les patients avec des antécédents de maladies hématologiques ou des allergies sont à risque accru.
Facteurs de risque Topotécan Antécédents médicaux
#2

Le topotécane est-il sûr pour les personnes âgées ?

Les personnes âgées peuvent être plus sensibles aux effets du topotécane et nécessitent une surveillance.
Personnes âgées Topotécan Surveillance médicale
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Dr Olivier Menir

Contenu validé par Dr Olivier Menir

Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale


Validation scientifique effectuée le 26/08/2026

Contenu vérifié selon les dernières recommandations médicales

Auteurs principaux

Nadezhda S Dyrkheeva

4 publications dans cette catégorie

Affiliations :
  • Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.

Olga I Lavrik

4 publications dans cette catégorie

Affiliations :
  • Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
  • V. Zelman Institute for the Medicine and Psychology, Novosibirsk State University, 630090 Novosibirsk, Russia.

O A Luzina

4 publications dans cette catégorie

Affiliations :
  • N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

N F Salakhutdinov

4 publications dans cette catégorie

Affiliations :
  • N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

Jasmine H Francis

3 publications dans cette catégorie

Affiliations :
  • Ophthalmic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Department of Ophthalmology, Weill Cornell Medical College, New York, New York, USA.

David H Abramson

3 publications dans cette catégorie

Affiliations :
  • Ophthalmic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
  • Department of Ophthalmology, Weill Cornell Medical College, New York, New York, USA.

Tatyana E Kornienko

3 publications dans cette catégorie

Affiliations :
  • Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.

Radka Hobzova

3 publications dans cette catégorie

Affiliations :
  • Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, 162 06 Prague, Czech Republic.

Jakub Sirc

3 publications dans cette catégorie

Affiliations :
  • Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, 162 06 Prague, Czech Republic.

Ana-Irina Cocarta

3 publications dans cette catégorie

Affiliations :
  • Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, 162 06 Prague, Czech Republic.

Nariman F Salakhutdinov

3 publications dans cette catégorie

Affiliations :
  • N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9, Akademika Lavrentieva Ave., 630090 Novosibirsk, Russia.

A L Zakharenko

3 publications dans cette catégorie

Affiliations :
  • Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

O I Lavrik

3 publications dans cette catégorie

Affiliations :
  • Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia. lavrik@niboch.nsc.ru.

Aleksandra L Zakharenko

2 publications dans cette catégorie

Affiliations :
  • Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.

Ekaterina S Ilina

2 publications dans cette catégorie

Affiliations :
  • Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
  • V. Zelman Institute for the Medicine and Psychology, Novosibirsk State University, 630090 Novosibirsk, Russia.

Peter Canoll

2 publications dans cette catégorie

Affiliations :
  • Department of Cell Biology and Pathology, Columbia University Irving Medical Center, New York, NY 10032, USA.

Jeffrey N Bruce

2 publications dans cette catégorie

Affiliations :
  • Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA.

Seung-Hyun Jeong

2 publications dans cette catégorie

Affiliations :
  • College of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, Republic of Korea.
Publications dans "Topotécane" :

Ji-Hun Jang

2 publications dans cette catégorie

Affiliations :
  • College of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, Republic of Korea.
Publications dans "Topotécane" :

Yong-Bok Lee

2 publications dans cette catégorie

Affiliations :
  • College of Pharmacy, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 61186, Republic of Korea. Electronic address: leeyb@chonnam.ac.kr.
Publications dans "Topotécane" :

Sources (31 au total)

The TGFBI gene and protein expression in topotecan resistant ovarian cancer cell lines.

The primary limiting factor in achieving cures for patients with cancer, particularly ovarian cancer, is drug resistance. The mechanisms of drug resistance of cancer cells during chemotherapy may incl... In this study, we conducted a detailed analysis of TGFBI expression in different ovarian cancer cell lines (A2780, A2780TR1, A2780TR2, W1, W1TR, SKOV-3, PEA1, PEA2 and PEO23). The level of TGFBI mRNA ... We observed upregulation of TGFBI mRNA in drug-resistant cell lines and estrogen-receptor positive cell lines, which was supported by overexpression of both intracellular and extracellular TGFBI prote... The expression of TGFBI in ovarian cancer cell lines suggests its role in the development of drug resistance....

A simulated trial with reinforcement learning for the efficacy of Irinotecan and Ifosfamide versus Topotecan in relapsed, extensive stage small cell lung cancer.

Synthetic data may proxy clinical data. At the absence of direct clinical data, this study aimed to compare Irinotecan and Ifosfamide (II) with Topotecan in synthetic, recurrent small cell lung cancer... Two simulation stages were conducted. Initially, 200 recurrent SCLC cases were simulated to replicate a previous phase 3 trial, testing the utility of Cox proportional hazards model and simulation met... CAV versus Topotecan comparison showed no statistical difference in overall survival (hazard ratio (HR): 0.89, 95% CI: 0.67-1.18, P = 0.418), aligning with the original clinical trial. For the Topotec... Artificial trial results for CAV versus Topotecan matched the original trial, confirming indifference of OAS. Additionally, II yielded superior overall survival compared to Topotecan in recurrent SCLC...

Berzosertib Plus Topotecan vs Topotecan Alone in Patients With Relapsed Small Cell Lung Cancer: A Randomized Clinical Trial.

Patients with relapsed small cell lung cancer (SCLC), a high replication stress tumor, have poor prognoses and few therapeutic options. A phase 2 study showed antitumor activity with the addition of t... To investigate whether the addition of berzosertib to topotecan improves clinical outcomes for patients with relapsed SCLC.... Between December 1, 2019, and December 31, 2022, this open-label phase 2 randomized clinical trial recruited 60 patients with SCLC and relapse after 1 or more prior therapies from 16 US cancer centers... Eligible patients were randomly assigned to receive topotecan alone (group 1), 1.25 mg/m2 intravenously on days 1 through 5, or with berzosertib (group 2), 210 mg/m2 intravenously on days 2 and 5, in ... The primary end point was progression-free survival (PFS) in the intention-to-treat population. Secondary end points included overall survival (OS) in the overall population and among patients with pl... Of 60 patients (median [range] age, 59 [34-79] years; 33 [55%] male) included in this study, 20 were randomly assigned to receive topotecan alone and 40 to receive a combination of topotecan with berz... In this randomized clinical trial, treatment with berzosertib plus topotecan did not improve PFS compared with topotecan therapy alone among patients with relapsed SCLC. However, the combination treat... ClinicalTrials.gov Identifier: NCT03896503....

Lurbinectedin in patients with small cell lung cancer with chemotherapy-free interval ≥30 days and without central nervous metastases.

This report focuses on lurbinectedin activity and safety in a subgroup of small cell lung cancer (SCLC) patients from a Basket phase 2 study (Trigo et al. Lancet Oncology 2020;21:645-654) with chemoth... Patients with extensive-stage SCLC, no central nervous system (CNS) metastases, and disease progression after platinum-containing therapy were included. Topotecan data from a contemporary, randomized,... Lurbinectedin showed a statistically significant higher overall response rate (ORR) by investigator assessment (IA) compared to topotecan subgroup (41.0 % vs. 25.5 %; p = 0.0382); higher ORR by Indepe... With the limitations of an indirect comparison, however using recent and comparable SCLC datasets, this post hoc analysis shows that SCLC patients with CTFI ≥ 30 days and no CNS metastases have a posi...

Drug-Induced Conformational Dynamics of P-Glycoprotein Underlies the Transport of Camptothecin Analogs.

P-glycoprotein (Pgp) plays a pivotal role in drug bioavailability and multi-drug resistance development. Understanding the protein's activity and designing effective drugs require insight into the mec...