Structural insights into G protein activation by D1 dopamine receptor.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
10 06 2022
10 06 2022
Historique:
entrez:
10
6
2022
pubmed:
11
6
2022
medline:
15
6
2022
Statut:
ppublish
Résumé
G protein-coupled receptors (GPCRs) comprise the largest family of membrane receptors and are the most important drug targets. An agonist-bound GPCR engages heterotrimeric G proteins and triggers the exchange of guanosine diphosphate (GDP) with guanosine triphosphate (GTP) to promote G protein activation. A complete understanding of molecular mechanisms of G protein activation has been hindered by a lack of structural information of GPCR-G protein complex in nucleotide-bound states. Here, we report the cryo-EM structures of the D1 dopamine receptor and mini-G
Identifiants
pubmed: 35687690
doi: 10.1126/sciadv.abo4158
pmc: PMC9187227
doi:
Substances chimiques
Receptors, Dopamine
0
Guanosine Diphosphate
146-91-8
Guanosine Triphosphate
86-01-1
GTP-Binding Proteins
EC 3.6.1.-
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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