Nuclear Dishevelled: An enigmatic role in governing cell fate and Wnt signaling.

Cell Nucleus / genetics Dishevelled Proteins / genetics Gastrulation Wnt Proteins / metabolism Wnt Signaling Pathway
Cancer Dishevelled EZH2 KMT2D Nucleus Post translational modifications Robinow syndrome SIRT1 TCF Wnt beta-catenin epigenetic regulation histone deacetylases histone methyl transferases lysine acetylation lysine methylation nuclear translocation

Journal

Biochimica et biophysica acta. Molecular cell research
ISSN: 1879-2596
Titre abrégé: Biochim Biophys Acta Mol Cell Res
Pays: Netherlands
ID NLM: 101731731

Informations de publication

Date de publication:
10 2022
Historique:
received: 31 03 2022
revised: 26 05 2022
accepted: 29 05 2022
pubmed: 11 6 2022
medline: 10 8 2022
entrez: 10 6 2022
Statut: ppublish

Résumé

The Dishevelled gene was first identified in Drosophila mutants with disoriented hair and bristle polarity and subsequent work has now demonstrated its importance in critical and diverse aspects of biology. Since those early discoveries, Dishevelled has been shown to coordinate a plethora of developmental and cellular processes that range from controlling cell polarity during gastrulation to partnering with chromatin modifying enzymes to regulate histone methylation at genomic loci. While the role of DVL in development is well-respected and the cytosolic function of DVL has been studied more extensively, its nuclear role continues to remain murky. In this review we highlight some of the seminal discoveries that have contributed to the field, but the primary focus is to discuss recent advances with respect to the nuclear role of Dishevelled. This nuclear function of Dishevelled is a dimension which is proving to be increasingly important yet remains enigmatic.

Identifiants

DOI: 10.1016/j.bbamcr.2022.119305 PMID: 35688346
pubmed: 35688346
pii: S0167-4889(22)00097-0
doi: 10.1016/j.bbamcr.2022.119305
pii:
doi:

Substances chimiques

Dishevelled Proteins 0
Wnt Proteins 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

119305

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

Auteurs

Geetha Priya Boligala (GP)

Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Mingxiao V Yang (MV)

Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Jenna C van Wunnik (JC)

Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Kevin Pruitt (K)

Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, TX, USA. Electronic address: kevin.pruitt@ttuhsc.edu.

Articles similaires

DPP an extracellular matrix molecule induces Wnt5a mediated signaling to promote the differentiation of adult stem cells into odontogenic lineage.

Yinghua Chen, Adrienn Petho, Amudha Ganapathy et al.
1.00
Wnt-5a Protein Animals Cell Differentiation Odontogenesis Humans

High expression of LncRNA HOTAIR is a risk factor for temozolomide resistance in glioblastoma via activation of the miR-214/β-catenin/MGMT pathway.

Tian Lan, Wei Quan, Dong-Hu Yu et al.
1.00
Humans Temozolomide RNA, Long Noncoding Glioblastoma Drug Resistance, Neoplasm

Lineage tracing of nuclei in skeletal myofibers uncovers distinct transcripts and interplay between myonuclear populations.

Chengyi Sun, Casey O Swoboda, Fabian Montecino Morales et al.
1.00
Animals Cell Nucleus Cell Lineage Mice Muscle Fibers, Skeletal

Ror2 signaling regulated by differential Wnt proteins determines pathological fate of muscle mesenchymal progenitors.

Koki Kamizaki, Mitsuko Katsukawa, Ayano Yamamoto et al.
1.00
Receptor Tyrosine Kinase-like Orphan Receptors Animals Mesenchymal Stem Cells Mice Muscle, Skeletal

Classifications MeSH

questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Noyau de la cellule › Nuclear Dishevelled: An enigmatic role in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Protéines Dishevelled › Nuclear Dishevelled: An enigmatic role in...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Morphogenèse › Gastrulation › Nuclear Dishevelled: An enigmatic role in...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de type Wingless › Nuclear Dishevelled: An enigmatic role in...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Voie de signalisation Wnt › Nuclear Dishevelled: An enigmatic role in...