Autoimmune hepatitis: Challenges and novelties.

Hepatitis autoinmune: retos y novedades.
Autoantibodies Azathioprine / therapeutic use Female Hepatitis, Autoimmune / diagnosis Humans Immunoglobulin G / therapeutic use Immunosuppressive Agents / therapeutic use Transaminases / therapeutic use
Acute autoimmune hepatitis Antibodies Anticuerpos Autoimmune hepatitis Daño hepático por fármacos Drug-induced liver injury Hepatitis autoinmune Hepatitis autoinmune aguda Tratamiento Treatment

Journal

Medicina clinica
ISSN: 1578-8989
Titre abrégé: Med Clin (Barc)
Pays: Spain
ID NLM: 0376377

Informations de publication

Date de publication:
23 09 2022
Historique:
received: 10 02 2022
revised: 04 04 2022
accepted: 06 04 2022
pubmed: 11 6 2022
medline: 23 9 2022
entrez: 10 6 2022
Statut: ppublish

Résumé

Autoimmune hepatitis is a chronic inflammatory disease of the liver. The etiology is partly unknown and commonly affects women of all ages. It is characterized by increase in transaminase and immunoglobulin G levels, autoantibodies, and portal inflammatory infiltrate with interface hepatitis in the liver biopsy. The treatment is based on the combination of corticoids and azathioprine, but 20-40% of patients require second- or third-line therapies due to intolerance or insufficient response. Here, we will revise the most important aspects regarding the diagnosis and treatment of autoimmune hepatitis emphasizing the challenges faced in clinical practice.

Identifiants

DOI: 10.1016/j.medcli.2022.04.004 PMID: 35688746
pubmed: 35688746
pii: S0025-7753(22)00182-8
doi: 10.1016/j.medcli.2022.04.004
pii:
doi:

Substances chimiques

Autoantibodies 0
Immunoglobulin G 0
Immunosuppressive Agents 0
Transaminases EC 2.6.1.-
Azathioprine MRK240IY2L

Types de publication

Journal Article Review

Langues

eng spa

Sous-ensembles de citation

IM

Pagination

289-298

Informations de copyright

Copyright © 2022 Elsevier España, S.L.U. All rights reserved.

Auteurs

Ignasi Olivas (I)

Servicio de Hepatología, Hospital Clínic, Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, España.

Sergio Rodríguez-Tajes (S)

Servicio de Hepatología, Hospital Clínic, Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, España.

Maria Carlota Londoño (MC)

Servicio de Hepatología, Hospital Clínic, Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, España. Electronic address: mlondono@clinic.cat.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Autoanticorps › Autoimmune hepatitis: Challenges and novelties.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Thionucléosides › Azathioprine › Autoimmune hepatitis: Challenges and novelties.
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Hépatite auto-immune › Autoimmune hepatitis: Challenges and novelties.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Autoimmune hepatitis: Challenges and novelties.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline G › Autoimmune hepatitis: Challenges and novelties.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Immunosuppresseurs › Autoimmune hepatitis: Challenges and novelties.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Nitrogenous group transferases › Transaminases › Autoimmune hepatitis: Challenges and novelties.