Haven't lost the positive feeling: a dose-response, oral alcohol challenge study in drinkers with alcohol use disorder.
Journal
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
ISSN: 1740-634X
Titre abrégé: Neuropsychopharmacology
Pays: England
ID NLM: 8904907
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
22
11
2021
accepted:
03
05
2022
revised:
21
04
2022
pubmed:
15
6
2022
medline:
23
9
2022
entrez:
14
6
2022
Statut:
ppublish
Résumé
Models of addiction are based on neurobiological, behavioral, and pharmacological studies in animals, but translational support from human studies is limited. Studies are lacking in examining acute responses to alcohol in drinkers with alcohol use disorder (AUD), particularly in terms of relevant intoxicating doses and measurement of stimulating and rewarding effects throughout the breath alcohol concentration (BrAC) time curve. Participants were N = 60 AUD drinkers enrolled in the Chicago Social Drinking Project and examined in three random-order and blinded sessions for subjective and physiological responses to a beverage containing 0.0 g/kg, 0.8 g/kg, and 1.2 g/kg alcohol. BrAC in the alcohol sessions at 60 min was 0.09 g/dL and 0.13 g/dL, respectively. Both doses of alcohol produced significant biphasic effects on subjective measures of stimulation, euphoria, reward (liking and wanting), sedation, and neuroendocrine and cardiovascular factors. Increased pleasurable effects of alcohol were pronounced during the rising limb-to-peak BrAC and sedating effects emerged during the declining limb. Alcohol dose-dependently increased feel drug ratings and rewarding effects at peak BrAC or early declining limb, and physiological responses at the rising limb. Thus, rather than the notion of an overall tolerance, results show an alcohol response phenotype characterized by sensitivity to alcohol's stimulating, rewarding and physiological effects. The results of this study may aid in the conceptualization of alcohol addiction as a disorder characterized by the persistence of enhanced hedonic alcohol responses rather than chronic tolerance and reward deficiency.
Identifiants
pubmed: 35701549
doi: 10.1038/s41386-022-01340-2
pii: 10.1038/s41386-022-01340-2
pmc: PMC9485138
doi:
Substances chimiques
Ethanol
3K9958V90M
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1892-1900Subventions
Organisme : NIAAA NIH HHS
ID : R01 AA013746
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA043469
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to American College of Neuropsychopharmacology.
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