Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication.

Animals Dendritic Cells Humans Indoleamine-Pyrrole 2,3,-Dioxygenase / metabolism Kynurenine / metabolism Mice Signal Transduction Tryptophan / metabolism
AhR IDO1 IL-6 RelB dendritic cells immunotolerance kynurenine metabolites neuroinflammation tryptophan metabolism

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
14 06 2022
Historique:
received: 31 08 2021
revised: 07 02 2022
accepted: 17 05 2022
entrez: 15 6 2022
pubmed: 16 6 2022
medline: 18 6 2022
Statut: ppublish

Résumé

Conventional dendritic cells (cDCs), cDC1 and cDC2, act both to initiate immunity and maintain self-tolerance. The tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) is used by cDCs in maintaining tolerance, but its role in different subsets remains unclear. At homeostasis, only mature CCR7

Identifiants

DOI: 10.1016/j.immuni.2022.05.013 PMID: 35704993 PMC: PMC9220322
pubmed: 35704993
pii: S1074-7613(22)00233-3
doi: 10.1016/j.immuni.2022.05.013
pmc: PMC9220322
pii:
doi:

Substances chimiques

Indoleamine-Pyrrole 2,3,-Dioxygenase 0
Kynurenine 343-65-7
Tryptophan 8DUH1N11BX

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1032-1050.e14

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI150297
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007163
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

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Auteurs

Marco Gargaro (M)

Department of Medicine and Surgery, University of Perugia, Perugia, Italy; Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.

Giulia Scalisi (G)

Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

Giorgia Manni (G)

Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

Carlos G Briseño (CG)

Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.

Prachi Bagadia (P)

Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.

Vivek Durai (V)

Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.

Derek J Theisen (DJ)

Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.

Sunkyung Kim (S)

Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.

Marilena Castelli (M)

Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

Chenling A Xu (CA)

Department of Electrical Engineering & Computer Science, Center for Computational Biology, University of California, Berkeley, CA, USA.

Gerd Meyer Zu Hörste (G)

Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany.

Giuseppe Servillo (G)

Department of Medicine and Surgery, University of Perugia, Perugia, Italy; University research center in functional genomics (c.u.r.ge.f.), University of Perugia, Perugia, Italy.

Maria A Della Fazia (MA)

Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

Giulia Mencarelli (G)

Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

Doriana Ricciuti (D)

Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

Eleonora Padiglioni (E)

Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

Nicola Giacchè (N)

TES Pharma, Loc. Taverne, Corciano, Italy.

Carolina Colliva (C)

TES Pharma, Loc. Taverne, Corciano, Italy.

Roberto Pellicciari (R)

TES Pharma, Loc. Taverne, Corciano, Italy.

Mario Calvitti (M)

Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

Teresa Zelante (T)

Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

Dietmar Fuchs (D)

Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria.

Ciriana Orabona (C)

Department of Medicine and Surgery, University of Perugia, Perugia, Italy.

Louis Boon (L)

Bioceros, Utrecht, the Netherlands.

Alban Bessede (A)

Immusmol, Bordeaux, France.

Marco Colonna (M)

Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.

Paolo Puccetti (P)

Department of Medicine and Surgery, University of Perugia, Perugia, Italy; University research center in functional genomics (c.u.r.ge.f.), University of Perugia, Perugia, Italy.

Theresa L Murphy (TL)

Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.

Kenneth M Murphy (KM)

Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA; Howard Hughes Medical Institute, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. Electronic address: kmurphy@wustl.edu.

Francesca Fallarino (F)

Department of Medicine and Surgery, University of Perugia, Perugia, Italy; University research center in functional genomics (c.u.r.ge.f.), University of Perugia, Perugia, Italy. Electronic address: francesca.fallarino@unipg.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Indoleamine 2,3-dioxygenase 1 activation in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système phagocytaire mononucléé › Cellules dendritiques › Indoleamine 2,3-dioxygenase 1 activation in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Indoleamine 2,3-dioxygenase 1 activation in...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Dioxygenases › Indoleamine-pyrrole 2,3,-dioxygenase › Indoleamine 2,3-dioxygenase 1 activation in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Cynurénine › Indoleamine 2,3-dioxygenase 1 activation in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Indoleamine 2,3-dioxygenase 1 activation in...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Indoleamine 2,3-dioxygenase 1 activation in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés essentiels › Tryptophane › Indoleamine 2,3-dioxygenase 1 activation in...