Caspase-1 and interleukin-18 in children with post infectious bronchiolitis obliterans: a case-control study.
Caspase-1
Children
IL-18
Post infectious bronchiolitis obliterans
Journal
European journal of pediatrics
ISSN: 1432-1076
Titre abrégé: Eur J Pediatr
Pays: Germany
ID NLM: 7603873
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
11
03
2022
accepted:
09
06
2022
revised:
18
05
2022
pubmed:
16
6
2022
medline:
9
8
2022
entrez:
15
6
2022
Statut:
ppublish
Résumé
The exact immunological mechanisms of post infectious bronchiolitis obliterans (PIBO) in childhood are not fully known. It has been shown that the inflammasome and IL-18 pathway play important roles in the pathogenesis of lung fibrosis. We aimed to investigate the role of caspase-1, IL-18, and IL-18 components in PIBO. From January to May 2020, children with PIBO, children with history of influenza infection without PIBO, and healthy children were asked to participate in the study in three pediatric pulmonology centers. Serum caspase-1, IL-18, IL-18BP, IL-18R, and INF-γ levels were measured by ELISA and compared between the 3 groups. There were 21 children in the PIBO group, 16 children in the influenza group, and 39 children in the healthy control group. No differences in terms of age and gender between the 3 groups were found. IL-18 and IL-18BP levels were higher in the healthy control group (p = 0.018, p = 0.005, respectively). IL-18R was higher in the PIBO group (p = 0.001) and caspase-1 was higher in the PIBO and influenza group than the healthy control group (p = 0.002). IFN-γ levels did not differ between the 3 groups. IL-18BP/IL-18 was higher in the influenza group than the PIBO group and the healthy control group (p = 0.003). Caspase-1 level was increased in patients with PIBO which suggests that inflammasome activation may have a role in fibrosis; however, IL-18 level was found to be low. Mediators other than IL-18 may be involved in the inflammatory pathway in PIBO. Further immunological studies investigating inflammasome pathway are needed for PIBO with chronic inflammation. • Post infectious bronchiolitis obliterans (PIBO) is a rare, severe chronic lung disease during childhood which is associated with inflammation and fibrosis which lead to partial or complete luminal obstruction especially in small airways. • The exact immunological mechanisms of PIBO in childhood are not fully known. • Inflammasome activation persists even years after acute infection and may play a role in fibrosis in PIBO. • Mediators other than IL-18 may be involved in these inflammatory pathway.
Identifiants
pubmed: 35705877
doi: 10.1007/s00431-022-04528-2
pii: 10.1007/s00431-022-04528-2
doi:
Substances chimiques
IL18 protein, human
0
Inflammasomes
0
Intercellular Signaling Peptides and Proteins
0
Interleukin-18
0
interleukin-18 binding protein
0
Caspase 1
EC 3.4.22.36
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3093-3101Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Onay ZR, Ramasli Gursoy T, Aslan AT, Sismanlar Eyuboglu T, Kibar BS, Pekcan S, Hangul M, Kose M, Budakoglu II, Gokturk B (2020) Postinfectious bronchiolitis obliterans masked by misdiagnosis as asthma. Pediatr Pulmonol 55(4):1007–1011
doi: 10.1002/ppul.24690
Yazan H, Khalif F, Shadfaan LA, Bilgin S, Nursoy M, Cakir FB, Cakin ZE, Uzuner S, Cakir E (2021) Post- infectious bronchiolitis obliterans in children: clinical and radiological evaluation and long- term results. Heart Lung 50(5):660–666
doi: 10.1016/j.hrtlng.2021.05.001
Colom AJ, Teper AM (2019) Post-infectious bronchiolitis obliterans. Pediatr Pulmonol 54(2):212–219
pubmed: 30548423
He Y, Hara H, Núñez G (2016) Mechanism and regulation of NLRP3 inflammasome activation. Trends Biochem Sci 41(12):1012–1021
doi: 10.1016/j.tibs.2016.09.002
Artlett CM (2013) Inflammasomes in wound healing and fibrosis. J Pathol 229(2):157–167
doi: 10.1002/path.4116
Zhang LM, Zhang Y, Fei C, Zhang J, Wang L, Yi ZW, Gao G (2019) Neutralization of IL-18 by IL-18 binding protein ameliorates bleomycin-induced pulmonary fibrosis via inhibition of epithelial-mesenchymal transition. Biochem Biophys Res Commun 508(2):660–666
doi: 10.1016/j.bbrc.2018.11.129
Zhang H, Wang J, Wang L, Xie H, Chen L, He S (2018) Role of IL-18 in atopic asthma is determined by balance of IL-18/IL-18BP/IL-18R. J Cell Mol Med 22(1):354–373
doi: 10.1111/jcmm.13323
Liu DH, Cui W, Chen Q, Liu DH, Cui W, Chen Q, Huang CM et al (2011) Can circulating interleukin-18 differentiate between sarcoidosis and idiopathic pulmonary fibrosis? Scand J Clin Lab Invest 71(7):593–597
doi: 10.3109/00365513.2011.597871
Nakanishi K, Yoshimoto T, Tsutsui H, Okamura H (2001) Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu. Cytokine Growth Factor Rev 12:53–72
doi: 10.1016/S1359-6101(00)00015-0
Takahara M, Aoyama-Ishikawa M, Shuno K, Yamauhi C, Miyoshi M, Maeshige N, Usami M, Yamada T, Osako T, Nakao A, Kotani J (2013) Role of endogenous IL-18 in the lung during endotoxin-induced systemic inflammation. Acute Med Surg 1(1):23–30
doi: 10.1002/ams2.6
Wu H, Craft ML, Wang P, Wyburn KR, Chen G, Ma J, Hambly B, Chadban SJ (2008) IL-18 contributes to renal damage after ischemia-reperfusion. J Am Soc Nephrol 19(12):2331–2341
doi: 10.1681/ASN.2008020170
Gu H, Xie M, Xu L, Zheng X, Yang Y, Lv X (2015) The protective role of interleukin-18 binding protein in a murine model of cardiac ischemia/reperfusion injury. Transpl Int 28(12):1436–1444
doi: 10.1111/tri.12683
Xu F, Wen Z, Shi X, Fan J (2018) Inflammasome in the pathogenesis of pulmonary diseases. Exp Suppl 108:111–151
pubmed: 30536170
pmcid: 7123416
Yang Y, Yin G, Hao J, Xie Q, Liu Y (2017) Serum interleukin-18 level is associated with disease activity and interstitial lung disease in patients with dermatomyositis. Arch Rheumatol 32(3):181–188
doi: 10.5606/ArchRheumatol.2017.6175
Sims JE, Smith DE (2010) The IL-1 family: regulators of immunity. Nat Rev Immunol 10:89–102
doi: 10.1038/nri2691
Novick D, Kim SH, Fantuzzi G, Reznikov LL, Dinarello CA, Rubinstein M (1999) Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response. Immunity 10(1):127–136
doi: 10.1016/S1074-7613(00)80013-8
Bartels EM, Ribel-Madsen S (2013) Cytokine measurements and possible interference from heterophilic antibodies – problems and solutions experienced with rheumatoid factor. Methods 61(1):18–22
doi: 10.1016/j.ymeth.2012.12.015
Fischer GB, Sarria EE, Mattiello R, Mocelin HT, Castro-Rodriguez JA (2010) Post infectious bronchiolitis obliterans in children. Paediatr Respir Rev 11(4):233–239
doi: 10.1016/j.prrv.2010.07.005
Rosewich M, Zissler UM, Kheiri T, Voss S, Eickmeier O, Schulze J, Herrmann E, Dücker RP, Schubert R, Zielen S (2015) Airway inflammation in children and adolescents with bronchiolitis obliterans. Cytokine 73(1):156–162
doi: 10.1016/j.cyto.2014.10.026
Mistchenko AS, Diez RA, Mariani AL, Mistchenko AS, Diez RA, Mariani AL, Robaldo J, Maffey AF, Bayley-Bustamante G, Grinstein S et al (1994) Cytokines in adenoviral disease in children: association of interleukin-6, interleukin-8, and tumor necrosis factor alpha levels with clinical outcome. J Pediatr 124(5 Pt 1):714–720
doi: 10.1016/S0022-3476(05)81360-5
Costa ML, Stein RT, Bauer ME, Machado DC, Jones MH, Bertotto C, Pitrez PM (2005) Levels of Th1 and Th2 cytokines in children with post-infectious bronchiolitis obliterans. Ann Trop Paediatr 25(4):261–266
doi: 10.1179/146532805X72403
Hosseinian N, Cho Y, Lockey RF, Kolliputi N (2015) The role of the NLRP3 inflammasome in pulmonary diseases. Ther Adv Respir Dis 9(4):188–197
doi: 10.1177/1753465815586335
van de Veerdonk FL, Netea MG, Dinarello CA, Joosten LA (2011) Inflammasome activation and IL-1β and IL-18 processing during infection. Trends Immunol 32(3):110–116
doi: 10.1016/j.it.2011.01.003
Artlett CM, Sassi-Gaha S, Rieger JL, Boesteanu AC, Feghali-Bostwick CA, Katsikis PD (2011) The inflammasome activating caspase 1 mediates fibrosis and myofibroblast differentiation in systemic sclerosis. Arthritis Rheum 63(11):3563–3574
doi: 10.1002/art.30568
Müller T, Vieira RP, Grimm M, Dürk T, Cicko S, Zeiser R, Jakob T, Martin SF, Blumenthal B, Sorichter S, Ferrari D, Di Virgillio F, Idzko M (2011) A potential role for P2X7R in allergic airway inflammation in mice and humans. Am J Respir Cell Mol Biol 44(4):456–464
doi: 10.1165/rcmb.2010-0129OC
Beheshti M, Salehi Z, Abolfazli R, Shirzad H, Izad M (2020) Increased level of caspase-1 in the serum of relapsing-remitting multiple sclerosis (RRMS) patients. Iran J Allergy Asthma Immunol 19(5):534–538
pubmed: 33463121
McInnes IB, Gracie JA, Leung BP, Wei XQ, Liew FY (2000) Interleukin 18: a pleiotropic participant in chronic inflammation. Immunol Today 21(7):312–315
doi: 10.1016/S0167-5699(00)01648-0
Yasuda K, Nakanishi K, Tsutsui H (2019) Interleukin-18 in health and disease. Int J Mol Sci 20(3):649
doi: 10.3390/ijms20030649
Nakanishi K, Yoshimoto T, Tsutsui H, Okamura H (2001) Interleukin-18 regulates both Th1 and Th2 responses. Annu Rev Immunol 19:423–474
doi: 10.1146/annurev.immunol.19.1.423
Kaplanski G (2018) Interleukin-18: biological properties and role in disease pathogenesis. Immunol Rev 281(1):138–153
doi: 10.1111/imr.12616
Novick D, Schwartsburd B, Pinkus R, Suissa D, Belzer I, Sthoeger Z, Keane WF, Chvatchko Y, Kim SH, Fantuzzi G, Dinarello CA, Rubinstein M (2001) A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18. Cytokine 14:334–342
doi: 10.1006/cyto.2001.0914
Hossny EM, El-Sayed SS, El-Hadidi ES, Moussa SR (2009) Serum interleukin-18 expression in children with bronchial asthma. World Allergy Organ J 2(5):63–68
doi: 10.1097/WOX.0b013e3181a33649
Cebeci AN, Nuhoglu Y, Arslanoglu I, Erguven M, Agachan N (2006) The role of IL-18 in Th1/Th2 balance in children. Allergy Asthma Proc 2:365–370
doi: 10.2500/aap.2006.27.2894
Ho LP, Davis M, Denison A, Wood FT, Greening AP (2002) Reduced interleukin-18 levels in BAL specimens from patients with asthma compared to patients with sarcoidosis and healthy control subjects. Chest 2:1421–1426
doi: 10.1378/chest.121.5.1421
Zhang L, Irion K, Kozakewich H, Reid L, Camargo JJ, da Silva PN, Abreu e Silva FA, (2000) Clinical course of postinfectious bronchiolitis obliterans. Pediatr Pulmonol 29:341–350
doi: 10.1002/(SICI)1099-0496(200005)29:5<341::AID-PPUL2>3.0.CO;2-4
Mauad T, van Schadewijk A, Schrumpf J, Hack CE, Fernezlian S, Garippo AL, Ejzenberg B, Hiemstra PS, Rabe KF, Dolhnikoff M; São Paulo BO Study Group (2004) Lymphocytic inflammation in childhood bronchiolitis obliterans. Pediatr Pulmonol 38:233–299
doi: 10.1002/ppul.20064
Liu S, Guo L, Chen M, Liu W, Li Y, Wang X, Li S, Zhang J, Ni X (2021) Evaluation of caspase-1, ınterleukin-1β, and ınterleukin-18, in the middle ear effusion in children with otitis media with effusion. Front Pediatr 9:732973
doi: 10.3389/fped.2021.732973