Early changes in estimated glomerular filtration rate post-initiation of empagliflozin in EMPEROR-Reduced.
Empagliflozin
Estimated glomerular filtration rate
Heart failure with reduced ejection fraction
Outcomes
Journal
European journal of heart failure
ISSN: 1879-0844
Titre abrégé: Eur J Heart Fail
Pays: England
ID NLM: 100887595
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
revised:
18
05
2022
received:
06
10
2021
accepted:
09
06
2022
pubmed:
18
6
2022
medline:
29
11
2022
entrez:
17
6
2022
Statut:
ppublish
Résumé
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) may induce an early post-initiation decrease of estimated glomerular filtration rate (eGFR), which does not impact the SGLT2i benefits. The occurrence, characteristics, determinants, and clinical significance of an initial eGFR change among patients with heart failure with reduced ejection fraction require further study. In this study we aimed to describe eGFR change from randomization to week 4 (as percent of change relative to randomization) and assess its impact in EMPEROR-Reduced. Landmark analyses (week 4) were performed. eGFR change was available in 3547 patients out of 3730 (95%). The tertiles of post-initiation % eGFR change for empagliflozin were: tertile 1 (T1) ≤-11.4%; T2 ≥-11.4% to ≤-1.0% and T3 ≥0.0%. The placebo group tertiles were: T1 ≤-6.5%; T2 ≥-6.4% to ≤+3.6%; and T3 ≥+3.6%. On average, empagliflozin induced a leftward distributional shift of initial eGFR changes of -2.5 ml/min/1.73 m A mild eGFR decrease may be expected after the initiation of empagliflozin, and it is not associated with untoward heart failure, mortality, or kidney safety events. Clinicians should not be concerned with early eGFR changes post-initiation of empagliflozin.
Substances chimiques
empagliflozin
HDC1R2M35U
Sodium-Glucose Transporter 2 Inhibitors
0
Banques de données
ClinicalTrials.gov
['NCT03057977']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1829-1839Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022 European Society of Cardiology.
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