Using genomics to understand the mechanisms of virulence and drug resistance in fungal pathogens.
drug resistance
genomics
infection
mycology
pathogenesis
Journal
Biochemical Society transactions
ISSN: 1470-8752
Titre abrégé: Biochem Soc Trans
Pays: England
ID NLM: 7506897
Informations de publication
Date de publication:
30 06 2022
30 06 2022
Historique:
received:
17
03
2022
revised:
27
05
2022
accepted:
06
06
2022
pubmed:
18
6
2022
medline:
2
7
2022
entrez:
17
6
2022
Statut:
ppublish
Résumé
Fungal pathogens pose an increasingly worrying threat to human health, food security and ecosystem diversity. To tackle fungal infections and improve current diagnostic and therapeutic tools it is necessary to understand virulence and antifungal drug resistance mechanisms in diverse species. Recent advances in genomics approaches have provided a suitable framework to understand these phenotypes, which ultimately depend on genetically encoded determinants. In this work, we review how the study of genome sequences has been key to ascertain the bases of virulence and drug resistance traits. We focus on the contribution of comparative genomics, population genomics and directed evolution studies. In addition, we discuss how different types of genomic mutations (small or structural variants) contribute to intraspecific differences in virulence or drug resistance. Finally, we review current challenges in the field and anticipate future directions to solve them. In summary, this work provides a short overview of how genomics can be used to understand virulence and drug resistance in fungal pathogens.
Identifiants
pubmed: 35713390
pii: 231437
doi: 10.1042/BST20211123
pmc: PMC9246328
doi:
Substances chimiques
Virulence Factors
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1259-1268Informations de copyright
© 2022 The Author(s).
Références
Genome Biol. 2021 Jul 12;22(1):202
pubmed: 34253237
Biol Rev Camb Philos Soc. 2019 Aug;94(4):1443-1476
pubmed: 31021528
Genetics. 2009 Jul;182(3):799-811
pubmed: 19414562
J Fungi (Basel). 2017 Oct 18;3(4):
pubmed: 29371573
Pathog Immun. 2018;3(2):183-196
pubmed: 30465032
IMA Fungus. 2021 Oct 11;12(1):29
pubmed: 34635188
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2688-93
pubmed: 19204294
Mycoses. 2018 Jul;61(7):430-440
pubmed: 29464833
Proc Natl Acad Sci U S A. 2022 Feb 22;119(8):
pubmed: 35169080
Front Pharmacol. 2018 Nov 20;9:1338
pubmed: 30515098
Nat Microbiol. 2021 Dec;6(12):1526-1536
pubmed: 34819642
Microb Cell. 2019 Feb 08;6(3):142-159
pubmed: 30854392
Curr Genet. 2020 Jun;66(3):549-559
pubmed: 31865398
ISME J. 2017 May;11(5):1189-1204
pubmed: 28117833
Antimicrob Agents Chemother. 2017 Aug 24;61(9):
pubmed: 28630186
FEMS Microbiol Rev. 2019 Sep 1;43(5):517-547
pubmed: 31158289
Trends Parasitol. 2015 Sep;31(9):426-34
pubmed: 26166750
Genome Med. 2014 Nov 20;6(11):100
pubmed: 25505934
BMC Genomics. 2020 Mar 20;21(1):247
pubmed: 32197579
Bioessays. 2017 Sep;39(9):
pubmed: 28782202
Genome Biol. 2016 Jun 06;17(1):122
pubmed: 27268795
Nature. 2012 Apr 11;484(7393):186-94
pubmed: 22498624
BMC Bioinformatics. 2017 Jul 20;18(1):346
pubmed: 28728542
Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W382-8
pubmed: 15980494
Clin Infect Dis. 2015 Dec 1;61 Suppl 6:S612-7
pubmed: 26567278
Antimicrob Agents Chemother. 2019 Jan 29;63(2):
pubmed: 30478162
Mol Plant Microbe Interact. 2018 Aug;31(8):779-788
pubmed: 29664319
BMC Genomics. 2016 May 20;17:385
pubmed: 27206972
Science. 2018 Nov 2;362(6414):589-595
pubmed: 30385579
Elife. 2019 Jun 07;8:
pubmed: 31172944
Genome Res. 2017 Jul;27(7):1207-1219
pubmed: 28611159
mBio. 2019 Dec 24;10(6):
pubmed: 31874914
PLoS Pathog. 2019 Jan 31;15(1):e1007478
pubmed: 30703166
New Phytol. 2018 Jan;217(2):756-770
pubmed: 29084346
Nat Microbiol. 2021 Jul;6(7):842-851
pubmed: 34083769
Microb Genom. 2020 Nov;6(11):
pubmed: 33206035
Genetics. 2021 Jun 24;218(2):
pubmed: 33837402
Nat Rev Genet. 2003 Jun;4(6):457-69
pubmed: 12776215
Clin Microbiol Infect. 2019 Jul;25(7):792-798
pubmed: 30965100
Elife. 2020 Jul 20;9:
pubmed: 32687060
BMC Genomics. 2015 Sep 07;16:686
pubmed: 26346253
Methods. 2020 Apr 1;176:82-90
pubmed: 31059831
FEMS Yeast Res. 2016 Mar;16(2):fov110
pubmed: 26684722
Nature. 2021 Aug;596(7873):583-589
pubmed: 34265844
Genes (Basel). 2018 Sep 19;9(9):
pubmed: 30235884
Eur Respir J. 2013 Mar;41(3):621-6
pubmed: 22743676
Front Microbiol. 2018 Dec 03;9:2946
pubmed: 30559734
PLoS Pathog. 2012;8(5):e1002718
pubmed: 22615574
PLoS One. 2019 Oct 9;14(10):e0223433
pubmed: 31596885
Antimicrob Agents Chemother. 2020 Dec 16;65(1):
pubmed: 33077664
Emerg Microbes Infect. 2018 Mar 7;7(1):24
pubmed: 29515103
Cell Host Microbe. 2019 Jul 10;26(1):12-14
pubmed: 31295419
BMC Genomics. 2016 Mar 05;17:191
pubmed: 26945779
Nat Commun. 2018 Dec 17;9(1):5346
pubmed: 30559369
Open Biol. 2021 Apr;11(4):200362
pubmed: 33906412
Fly (Austin). 2012 Apr-Jun;6(2):80-92
pubmed: 22728672
Front Microbiol. 2020 Sep 30;11:565439
pubmed: 33117312
Med Mycol. 2018 Apr 1;56(suppl_1):165-187
pubmed: 29538732
PLoS One. 2019 Jan 10;14(1):e0210397
pubmed: 30629653
Mol Biol Evol. 2019 Aug 1;36(8):1768-1782
pubmed: 31028698
Genome Biol. 2019 Nov 20;20(1):246
pubmed: 31747936
Curr Biol. 2018 Jan 8;28(1):15-27.e7
pubmed: 29249661
Pathogens. 2021 Jun 04;10(6):
pubmed: 34199862
Front Microbiol. 2019 Feb 12;10:112
pubmed: 30809200
Sci Rep. 2019 Mar 13;9(1):4307
pubmed: 30867521
Curr Biol. 2021 Dec 6;31(23):5314-5326.e10
pubmed: 34699784
Nucleic Acids Res. 2015 Dec 2;43(21):e143
pubmed: 26187991
Mycopathologia. 2020 Oct;185(5):765-781
pubmed: 31734800
mBio. 2021 Apr 5;12(2):
pubmed: 33820824
Lancet Infect Dis. 2017 Aug;17(8):873-881
pubmed: 28483415
PLoS Pathog. 2009 Jan;5(1):e1000268
pubmed: 19148266
Science. 2018 May 18;360(6390):739-742
pubmed: 29773744
Cold Spring Harb Perspect Med. 2014 Nov 03;5(1):a019273
pubmed: 25367975
Genes (Basel). 2020 Apr 14;11(4):
pubmed: 32295266
Clin Microbiol Infect. 2017 Aug;23(8):575.e1-575.e8
pubmed: 28196695
mSphere. 2017 Nov 22;2(6):
pubmed: 29202040
Front Genet. 2020 Aug 04;11:822
pubmed: 32849816
Nat Commun. 2018 Jun 8;9(1):2253
pubmed: 29884848
Front Genet. 2020 May 12;11:459
pubmed: 32477406
Nature. 2010 Mar 18;464(7287):367-73
pubmed: 20237561
BMC Biol. 2020 May 6;18(1):48
pubmed: 32375762
BMC Evol Biol. 2009 Dec 21;9:295
pubmed: 20025735
mBio. 2020 Apr 28;11(2):
pubmed: 32345637
Front Plant Sci. 2020 Sep 16;11:570180
pubmed: 33072145
Antibiotics (Basel). 2020 Dec 08;9(12):
pubmed: 33302565