Systemic inflammation response index (SIRI) as predictor of anastomotic leakage after total gastrectomy for gastric cancer.
Esophago-jejunostomy
Gastric cancer
Leakage
Predictor
Systemic inflammation response index
Journal
Surgical oncology
ISSN: 1879-3320
Titre abrégé: Surg Oncol
Pays: Netherlands
ID NLM: 9208188
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
25
01
2022
revised:
20
04
2022
accepted:
06
06
2022
pubmed:
19
6
2022
medline:
14
9
2022
entrez:
18
6
2022
Statut:
ppublish
Résumé
Esophago-jejunostomy leakage (EJL) it the most dreaded septic complication after total gastrectomy for gastric cancer. Early detection and treatment of this complication may improve outcomes. Systemic Inflammation Response Index (SIRI) is a marker that reflects systemic inflammation. The SIRI was developed in a training cohort of 180 patients who underwent elective open total gastrectomy with esophago-jejunal anastomosis for gastric cancer from January 2009 to December 2013. To verify the prognostic value of SIRI score we recruited 192 patients treated from January 2014 to December 2021 as the validation cohort. The optimal cut-off value of SIRI was determined by receiver operating characteristic curve. Univariate and multivariate analysis was performed. An optimal cut-off point for the SIRI of 0.82 divided the patients into a low SIRI group and high SIRI group in the training cohort. Patients with a SIRI ≥0.82 was found to be significantly associated with EJL. Univariable analysis showed that NLR, PLR, MLR, SII, and SIRI were prognostic factors for EJL in the training cohort. In multivariable analysis, EJL high level of SIRI was identified as independent prognostic factor. Preoperative SIRI may be helpful in identifying patients at greater risk for developing EJL after total gastrectomy.
Sections du résumé
BACKGROUND
BACKGROUND
Esophago-jejunostomy leakage (EJL) it the most dreaded septic complication after total gastrectomy for gastric cancer. Early detection and treatment of this complication may improve outcomes. Systemic Inflammation Response Index (SIRI) is a marker that reflects systemic inflammation.
METHODS
METHODS
The SIRI was developed in a training cohort of 180 patients who underwent elective open total gastrectomy with esophago-jejunal anastomosis for gastric cancer from January 2009 to December 2013. To verify the prognostic value of SIRI score we recruited 192 patients treated from January 2014 to December 2021 as the validation cohort. The optimal cut-off value of SIRI was determined by receiver operating characteristic curve. Univariate and multivariate analysis was performed.
RESULTS
RESULTS
An optimal cut-off point for the SIRI of 0.82 divided the patients into a low SIRI group and high SIRI group in the training cohort. Patients with a SIRI ≥0.82 was found to be significantly associated with EJL. Univariable analysis showed that NLR, PLR, MLR, SII, and SIRI were prognostic factors for EJL in the training cohort. In multivariable analysis, EJL high level of SIRI was identified as independent prognostic factor.
CONCLUSIONS
CONCLUSIONS
Preoperative SIRI may be helpful in identifying patients at greater risk for developing EJL after total gastrectomy.
Identifiants
pubmed: 35716547
pii: S0960-7404(22)00085-8
doi: 10.1016/j.suronc.2022.101791
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101791Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.