The Influence of Strain on the Rotation of an Artificial Molecular Motor.
Macrocycles
Molecular Motors
Photochemistry
Strained Molecules
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
22 08 2022
22 08 2022
Historique:
received:
20
04
2022
pubmed:
20
6
2022
medline:
19
8
2022
entrez:
19
6
2022
Statut:
ppublish
Résumé
In artificial small-molecule machines, molecular motors can be used to perform work on coupled systems by applying a mechanical load-such as strain-that allows for energy transduction. Here, we report how ring strain influences the rotation of a rotary molecular motor. Bridging the two halves of the motor with alkyl tethers of varying sizes yields macrocycles that constrain the motor's movement. Increasing the ring size by two methylene increments increases the mobility of the motor stepwise and allows for fine-tuning of strain in the system. Small macrocycles (8-14 methylene units) only undergo a photochemical E/Z isomerization. Larger macrocycles (16-22 methylene units) can perform a full rotational cycle, but thermal helix inversion is strongly dependent on the ring size. This study provides systematic and quantitative insight into the behavior of molecular motors under a mechanical load, paving the way for the development of complex coupled nanomachinery.
Identifiants
pubmed: 35718745
doi: 10.1002/anie.202205801
pmc: PMC9544085
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202205801Informations de copyright
© 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.
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