Effects of Structurally Different HDAC Inhibitors against

Animals Chagas Disease / drug therapy Histone Deacetylase Inhibitors / pharmacology Leishmania Schistosoma mansoni Trypanosoma cruzi
HDAC inhibitors Leishmania S. mansoni T. cruzi benzamides hydroxamates

Journal

ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580

Informations de publication

Date de publication:
08 07 2022
Historique:
pubmed: 23 6 2022
medline: 12 7 2022
entrez: 22 6 2022
Statut: ppublish

Résumé

Neglected tropical diseases (NTDs), including trypanosomiasis, leishmaniasis, and schistosomiasis, result in a significant burden in terms of morbidity and mortality worldwide every year. Current antiparasitic drugs suffer from several limitations such as toxicity, no efficacy toward all of the forms of the parasites' life cycle, and/or induction of resistance. Histone-modifying enzymes play a crucial role in parasite growth and survival; thus, the use of epigenetic drugs has been suggested as a strategy for the treatment of NTDs. We tested structurally different HDACi

Identifiants

DOI: 10.1021/acsinfecdis.2c00232 PMID: 35732073 PMC: PMC9274761
pubmed: 35732073
doi: 10.1021/acsinfecdis.2c00232
pmc: PMC9274761
doi:

Substances chimiques

Histone Deacetylase Inhibitors 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1356-1366

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Auteurs

Elisabetta Di Bello (E)

Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy.

Beatrice Noce (B)

Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy.

Rossella Fioravanti (R)

Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy.

Clemens Zwergel (C)

Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy.
ORCID: 0000-0002-3097-0003

Sergio Valente (S)

Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy.
ORCID: 0000-0002-2241-607X

Dante Rotili (D)

Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy.
ORCID: 0000-0002-8428-8763

Giulia Fianco (G)

Institute of Molecular Biology and Pathology, National Research Council (CNR), Via degli Apuli 4, 00185 Rome, Italy.

Daniela Trisciuoglio (D)

Institute of Molecular Biology and Pathology, National Research Council (CNR), Via degli Apuli 4, 00185 Rome, Italy.

Marina M Mourão (MM)

Instituto René Rachou, Fundação Oswaldo Cruz, Avenida Augusto de Lima, 1715, 30190-002 Belo Horizonte, Brazil.

Policarpo Sales (P)

Instituto René Rachou, Fundação Oswaldo Cruz, Avenida Augusto de Lima, 1715, 30190-002 Belo Horizonte, Brazil.

Suzanne Lamotte (S)

Institut Pasteur, Université Paris Cité, INSERM U1201, Unité de Parasitologie Moléculaire et Signalisation, 25-28 Rue du Docteur Roux, 75015 Paris, France.

Eric Prina (E)

Institut Pasteur, Université Paris Cité, INSERM U1201, Unité de Parasitologie Moléculaire et Signalisation, 25-28 Rue du Docteur Roux, 75015 Paris, France.

Gerald F Späth (GF)

Institut Pasteur, Université Paris Cité, INSERM U1201, Unité de Parasitologie Moléculaire et Signalisation, 25-28 Rue du Docteur Roux, 75015 Paris, France.

Cécile Häberli (C)

Swiss Tropical and Public Health Institute, 4002 Allschwil, Switzerland.
University of Basel, Peterspl. 1, 4001 Basel, Switzerland.

Jennifer Keiser (J)

Swiss Tropical and Public Health Institute, 4002 Allschwil, Switzerland.
University of Basel, Peterspl. 1, 4001 Basel, Switzerland.

Antonello Mai (A)

Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy.
Pasteur Institute, Cenci-Bolognetti Foundation, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy.
ORCID: 0000-0001-9176-2382

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Effects of Structurally Different HDAC...
questionsmedicales.fr › Infection › Maladies vectorielles › Maladie de Chagas › Effects of Structurally Different HDAC...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de désacétylase d'histone › Effects of Structurally Different HDAC...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Leishmania › Effects of Structurally Different HDAC...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Plathelminthes › Trematoda › Schistosomatidae › Schistosoma › Schistosoma mansoni › Effects of Structurally Different HDAC...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Trypanosoma › Trypanosoma cruzi › Effects of Structurally Different HDAC...