Transcriptional Pattern Analysis of Virus-Specific CD8+ T Cells in Hepatitis C Infection: Increased Expression of TOX and Eomesodermin During and After Persistent Antigen Recognition.
CD39
Eomesodermin
T cell differentiation
T cell exhaustion
TOX
acute viral hepatitis
chronic viral hepatitis
hepatitis C
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
28
02
2022
accepted:
13
04
2022
entrez:
23
6
2022
pubmed:
24
6
2022
medline:
25
6
2022
Statut:
epublish
Résumé
Thymocyte selection-associated high mobility group box (TOX) has been described to be a key regulator in the formation of CD8+ T cell exhaustion. Hepatitis C virus (HCV) infection with different lengths of antigen exposure in acute, chronic, and after resolution of HCV infection is the ideal immunological model to study the expression of TOX in HCV-specific CD8+ T cells with different exposure to antigen. HCV-specific CD8+ T cells from 35 HLA-A*01:01, HLA-A*02:01, and HLA-A*24:02 positive patients were analyzed with a 16-color FACS-panel evaluating the surface expression of lineage markers (CD3, CD8), ectoenzymes (CD39, CD73), markers of differentiation (CD45RO, CCR7, CD127), and markers of exhaustion and activation (TIGIT, PD-1, KLRG1, CD226) and transcription factors (TOX, Eomesodermin, T-bet). Here, we defined on-target T cells as T cells against epitopes without escape mutations and off-target T cells as those against a "historical" antigen mutated in the autologous sequence. TOX+HCV-specific CD8+ T cells from patients with chronic HCV and on-target T cells displayed co-expression of Eomesodermin and were associated with the formation of terminally exhausted CD127
Identifiants
pubmed: 35734162
doi: 10.3389/fimmu.2022.886646
pmc: PMC9207347
doi:
Substances chimiques
EOMES protein, human
0
HLA-A Antigens
0
High Mobility Group Proteins
0
T-Box Domain Proteins
0
TOX protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
886646Informations de copyright
Copyright © 2022 Wildner, Walker, Brauneck, Ditt, Peine, Huber, Haag, Beisel, Timm and Schulze zur Wiesch.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Annu Rev Immunol. 2019 Apr 26;37:457-495
pubmed: 30676822
J Immunother Cancer. 2020 Feb;8(1):
pubmed: 32098829
Eur J Immunol. 2021 Apr;51(4):915-929
pubmed: 33296081
J Hepatol. 2020 Nov;73(5):1170-1218
pubmed: 32956768
Oncoimmunology. 2019 Apr 2;8(6):e1593809
pubmed: 31069159
Nat Rev Immunol. 2019 Nov;19(11):665-674
pubmed: 31570879
Cancer Res. 2018 Jan 1;78(1):115-128
pubmed: 29066514
J Clin Virol. 2015 Sep;70:43-45
pubmed: 26305818
Immunity. 2018 May 15;48(5):1029-1045.e5
pubmed: 29768164
J Exp Med. 2018 Oct 1;215(10):2520-2535
pubmed: 30154266
J Virol. 2010 Feb;84(3):1656-63
pubmed: 19906915
Nature. 2019 Jul;571(7764):270-274
pubmed: 31207604
Nat Immunol. 2021 Feb;22(2):229-239
pubmed: 33398179
Immunity. 2012 Dec 14;37(6):1130-44
pubmed: 23159438
Nat Immunol. 2011 Jun;12(6):492-9
pubmed: 21739672
Nat Immunol. 2009 Jan;10(1):29-37
pubmed: 19043418
Biomed Res Int. 2019 Dec 14;2019:4093214
pubmed: 31930120
J Clin Virol. 2017 Jun;91:42-48
pubmed: 28463753
Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12410-12415
pubmed: 31152140
Nat Commun. 2017 May 03;8:15050
pubmed: 28466857
Cell Death Dis. 2015 Mar 19;6:e1694
pubmed: 25789969
Front Immunol. 2018 Dec 18;9:2981
pubmed: 30619337
J Virol. 2014 Oct;88(19):11080-90
pubmed: 25008925
Cold Spring Harb Perspect Biol. 2021 Oct 1;13(10):
pubmed: 33782027
Immunity. 2019 Nov 19;51(5):840-855.e5
pubmed: 31606264
Immunity. 2019 Dec 17;51(6):1043-1058.e4
pubmed: 31810882
FEBS Lett. 2015 Nov 14;589(22):3454-60
pubmed: 26226423
Nature. 2005 Aug 18;436(7053):946-52
pubmed: 16107834
Nat Immunol. 2021 Aug;22(8):1020-1029
pubmed: 34312547
Nature. 2019 Jul;571(7764):265-269
pubmed: 31207605
Sci Rep. 2019 Jul 23;9(1):10624
pubmed: 31337800
J Virol. 2006 Nov;80(22):11398-403
pubmed: 16956940
Mol Aspects Med. 2017 Jun;55:9-19
pubmed: 28093236
Viruses. 2018 Nov 17;10(11):
pubmed: 30453612
J Virol. 2000 Nov;74(21):10249-55
pubmed: 11024158
Purinergic Signal. 2018 Dec;14(4):309-320
pubmed: 30097807
J Exp Med. 2014 Sep 22;211(10):2047-59
pubmed: 25225458
Nat Immunol. 2021 Aug;22(8):1008-1019
pubmed: 34312545
J Immunother Cancer. 2021 Jul;9(7):
pubmed: 34253638
Gut. 2020 Oct 23;:
pubmed: 33097558
Immunity. 2016 Aug 16;45(2):415-27
pubmed: 27533016
World J Gastroenterol. 2014 Apr 7;20(13):3418-30
pubmed: 24707125
J Gynecol Oncol. 2012 Oct;23(4):274-81
pubmed: 23094131
Nat Med. 2013 Jul;19(7):859-68
pubmed: 23836236
J Leukoc Biol. 2013 Oct;94(4):551-61
pubmed: 23709688
J Exp Med. 2012 Jan 16;209(1):61-75
pubmed: 22213804
Oncoimmunology. 2021 Jun 21;10(1):1930391
pubmed: 34211801
Front Cell Dev Biol. 2021 Feb 18;9:638037
pubmed: 33681221
Cytometry A. 2015 Jul;87(7):636-45
pubmed: 25573116
Nature. 2019 Jul;571(7764):211-218
pubmed: 31207603
J Virol. 2007 Nov;81(21):11658-68
pubmed: 17699568
J Virol. 2008 Mar;82(6):3154-60
pubmed: 18160439
Immunity. 2020 May 19;52(5):825-841.e8
pubmed: 32396847
Nat Immunol. 2019 Jul;20(7):890-901
pubmed: 31209400
J Infect Dis. 2016 Dec 15;214(12):1965-1974
pubmed: 27683821
J Exp Med. 2001 Nov 19;194(10):1395-406
pubmed: 11714747
Virology. 2015 May;479-480:180-93
pubmed: 25620767
Nature. 2016 Sep 15;537(7620):417-421
pubmed: 27501248
J Exp Med. 2000 May 1;191(9):1499-512
pubmed: 10790425
Science. 2012 Nov 30;338(6111):1220-5
pubmed: 23197535
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2018 May 1;35(5):697-704
pubmed: 30370707
J Virol. 2007 Jan;81(2):945-53
pubmed: 17079288
Blood. 2000 Nov 1;96(9):3094-101
pubmed: 11049989
Science. 2016 Dec 2;354(6316):1160-1165
pubmed: 27789795
PLoS Pathog. 2010 Jun 10;6(6):e1000947
pubmed: 20548953
Biochimie. 2020 Sep;176:21-30
pubmed: 32585229
PLoS Pathog. 2015 Oct 20;11(10):e1005177
pubmed: 26485519
Sci Immunol. 2020 Jul 3;5(49):
pubmed: 32620560
Trends Mol Med. 2013 Jun;19(6):355-67
pubmed: 23601906