Endothelin B Receptor Immunodynamics in Pulmonary Arterial Hypertension.

Animals Autoantibodies / immunology Endothelin-1 / immunology Familial Primary Pulmonary Hypertension / immunology Humans Hypertrophy, Right Ventricular / immunology Inflammation / immunology Mice Pulmonary Arterial Hypertension / immunology Receptor, Endothelin B / immunology Scleroderma, Systemic / immunology
Th2 inflammation autoantibody endothelin B receptor pulmonary arterial hypertension pulmonary vascular hyperresponsiveness systemic sclerosis

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2022
Historique:
received: 13 03 2022
accepted: 09 05 2022
entrez: 27 6 2022
pubmed: 28 6 2022
medline: 29 6 2022
Statut: epublish

Résumé

Inflammation is a major pathological feature of pulmonary arterial hypertension (PAH), particularly in the context of inflammatory conditions such as systemic sclerosis (SSc). The endothelin system and anti-endothelin A receptor (ET Serum levels of anti-ET Anti-ET This study provides evidence for an anti-inflammatory role of ET

Identifiants

DOI: 10.3389/fimmu.2022.895501 PMID: 35757687 PMC: PMC9221837
pubmed: 35757687
doi: 10.3389/fimmu.2022.895501
pmc: PMC9221837
doi:

Substances chimiques

Autoantibodies 0
EDNRB protein, human 0
EDNRB protein, mouse 0
Endothelin-1 0
Receptor, Endothelin B 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

895501

Informations de copyright

Copyright © 2022 Tabeling, González Calera, Lienau, Höppner, Tschernig, Kershaw, Gutbier, Naujoks, Herbert, Opitz, Gruber, Hocher, Suttorp, Heidecke, Burmester, Riemekasten, Siegert, Kuebler and Witzenrath.

Déclaration de conflit d'intérêts

CT received funding for research from Deutsche Gesellschaft für Pneumologie, Bayer HealthCare, Boehringer Ingelheim, and for lectures from Actelion Pharmaceuticals, Boehringer Ingelheim. HH is CEO of CellTrend GmbH, Luckenwalde, Germany. MW received funding for research from Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung, Deutsche Gesellschaft für Pneumologie, European Respiratory Society, Marie Curie Foundation, Else Kröner Fresenius Stiftung, CAPNETZ STIFTUNG, International Max Planck Research School, Actelion, Bayer Health Care, Biotest AG, Boehringer Ingelheim, NOXXON Pharma, Pantherna, Quark Pharma, Silence Therapeutics, Vaxxilon, and for lectures and advisory from Actelion, Alexion, Aptarion, Astra Zeneca, Bayer Health Care, Berlin Chemie, Biotest, Boehringer Ingelheim, Chiesi, Glaxo Smith Kline, Insmed, Novartis, Teva and Vaxxilon. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Christoph Tabeling (C)

Division of Pulmonary Inflammation, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.

Carla R González Calera (CR)

Division of Pulmonary Inflammation, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Jasmin Lienau (J)

Division of Pulmonary Inflammation, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Jakob Höppner (J)

Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Thomas Tschernig (T)

Institute of Anatomy and Cell Biology, University of Saarland, Homburg, Germany.

Olivia Kershaw (O)

Department of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.

Birgitt Gutbier (B)

Division of Pulmonary Inflammation, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Jan Naujoks (J)

Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Julia Herbert (J)

Division of Pulmonary Inflammation, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Bastian Opitz (B)

Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Achim D Gruber (AD)

Department of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.

Berthold Hocher (B)

Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University of Heidelberg, University Medical Centre Mannheim, Heidelberg, Germany.
Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha, China.
Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China.

Norbert Suttorp (N)

Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
German Center for Lung Research (DZL), Partner Site Charité, Berlin, Germany.

Harald Heidecke (H)

CellTrend GmbH, Luckenwalde, Germany.

Gerd-R Burmester (GR)

Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Gabriela Riemekasten (G)

Department of Rheumatology, University of Lübeck, Lübeck, Germany.

Elise Siegert (E)

Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Wolfgang M Kuebler (WM)

German Center for Lung Research (DZL), Partner Site Charité, Berlin, Germany.
Institute of Physiology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site, Berlin, Germany.
St. Michael's Hospital, Keenan Research Centre for Biomedical Science, Toronto, ON, Canada.
Departments of Physiology and Surgery, University of Toronto, Toronto, ON, Canada.

Martin Witzenrath (M)

Division of Pulmonary Inflammation, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
German Center for Lung Research (DZL), Partner Site Charité, Berlin, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Endothelin B Receptor Immunodynamics in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Autoanticorps › Endothelin B Receptor Immunodynamics in...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Endothélines › Endothéline-1 › Endothelin B Receptor Immunodynamics in...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies pulmonaires › Hypertension artérielle pulmonaire primitive familiale › Endothelin B Receptor Immunodynamics in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Endothelin B Receptor Immunodynamics in...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Hypertrophie › Cardiomégalie › Hypertrophie ventriculaire droite › Endothelin B Receptor Immunodynamics in...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Endothelin B Receptor Immunodynamics in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Endothelin B Receptor Immunodynamics in...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies pulmonaires › Hypertension artérielle pulmonaire › Endothelin B Receptor Immunodynamics in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur endothéline › Récepteur de l'endothéline de type B › Endothelin B Receptor Immunodynamics in...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Sclérodermie systémique › Endothelin B Receptor Immunodynamics in...