Recent advances and challenges in graphene-based nanocomposite scaffolds for tissue engineering application.
graphene
graphene-based materials
nanocomposite
regenerative medicine
scaffold
stem cell
tissue engineering
Journal
Journal of biomedical materials research. Part A
ISSN: 1552-4965
Titre abrégé: J Biomed Mater Res A
Pays: United States
ID NLM: 101234237
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
revised:
22
05
2022
received:
07
03
2022
accepted:
08
06
2022
pubmed:
29
6
2022
medline:
5
8
2022
entrez:
28
6
2022
Statut:
ppublish
Résumé
Graphene-based nanocomposites have recently attracted increasing attention in tissue engineering because of their extraordinary features. These biocompatible substances, in the presence of an apt microenvironment, can stimulate and sustain the growth and differentiation of stem cells into different lineages. This review discusses the characteristics of graphene and its derivatives, such as their excellent electrical signal transduction, carrier mobility, outstanding mechanical strength with improving surface characteristics, self-lubrication, antiwear properties, enormous specific surface area, and ease of functional group modification. Moreover, safety issues in the application of graphene and its derivatives in terms of biocompatibility, toxicity, and interaction with immune cells are discussed. We also describe the applicability of graphene-based nanocomposites in tissue healing and organ regeneration, particularly in the bone, cartilage, teeth, neurons, heart, skeletal muscle, and skin. The impacts of special textural and structural characteristics of graphene-based nanomaterials on the regeneration of various tissues are highlighted. Finally, the present review gives some hints on future research for the transformation of these exciting materials in clinical studies.
Substances chimiques
Graphite
7782-42-5
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1695-1721Subventions
Organisme : National Institute of Dental & Craniofacial Research of the National Institutes of Health
ID : R15DE027533
Organisme : National Institute of Dental & Craniofacial Research of the National Institutes of Health
ID : 1R56 DE029191-01A1
Organisme : National Institute of Dental & Craniofacial Research of the National Institutes of Health
ID : 3R15DE027533-0
Organisme : Shahid Beheshti University of Medical Sciences, Tehran, Iran
ID : 29356
Informations de copyright
© 2022 Wiley Periodicals LLC.
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