Micromolding of Thermoplastic Polymers for Direct Fabrication of Discrete, Multilayered Microparticles.
drug delivery
multilayered microparticles
random copolymers
soft lithography
surface-segregating polymers
Journal
Small methods
ISSN: 2366-9608
Titre abrégé: Small Methods
Pays: Germany
ID NLM: 101724536
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
13
05
2022
pubmed:
29
6
2022
medline:
21
9
2022
entrez:
28
6
2022
Statut:
ppublish
Résumé
Soft lithography provides a convenient and effective method for the fabrication of microdevices with uniform size and shape. However, formation of an embossed, connective film as opposed to discrete features has been an enduring shortcoming associated with soft lithography. Removing this residual layer requires additional postprocessing steps that are often incompatible with organic materials. This limits adaptation and widespread realization of soft lithography for broader applications particularly in drug discovery and drug delivery fields. A novel and versatile approach is demonstrated that enables fabrication of discrete, multilayered, fillable, and harvestable microparticles directly from any thermoplastic polymer, even at very high molecular weights. The approach, isolated microparticle replication via surface-segregating polymer blend mold, utilizes a random copolymer additive, designed with a highly fluorinated segment that, when blended with the mold's matrix, spontaneously orients to the surface conferring an extremely low surface energy and nonwetting properties to the template. The extremely nonwetting properties of the mold are further utilized to load soluble biologics directly into the built-in microwells in a rapid and efficient manner using an innovative screen-printing approach. It is believed that this approach holds promise for fabrication of large-array, 3D, complex microstructures, and is a significant step toward clinical translation of microfabrication technologies.
Identifiants
pubmed: 35764872
doi: 10.1002/smtd.202200232
doi:
Substances chimiques
Biological Products
0
Plastics
0
Polymers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2200232Subventions
Organisme : Department of Comparative Medicine
Organisme : Microscopy Facility
Organisme : Whitehead Institute
Organisme : Bill & Melinda Gates Foundation
ID : OPP1095790
Pays : United States
Informations de copyright
© 2022 The Authors. Small Methods published by Wiley-VCH GmbH.
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