An integration-free iPSC line ZZUNEUi028-A derived from a patient with hypertrophic cardiomyopathy carrying a heterozygous mutation (c. 1504 C > T) in MYBPC3 gene.
Journal
Stem cell research
ISSN: 1876-7753
Titre abrégé: Stem Cell Res
Pays: England
ID NLM: 101316957
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
03
06
2022
revised:
16
06
2022
accepted:
19
06
2022
pubmed:
1
7
2022
medline:
10
8
2022
entrez:
30
6
2022
Statut:
ppublish
Résumé
Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease often caused by sarcomeric gene mutations. MYBPC3 is one of the most common genes associated with HCM. In this study, we generated a human induced pluripotent stem cell line ZZUNEUi028-A from a 19-year-old male HCM patient with c. 1504C → T in MYBPC3 gene using non-integrative Sendai viral reprogramming technology. This cell line expresses pluripotency markers, exhibits a normal male karyotype (46, XY) and can differentiate into all three germ layers in vitro. ZZUNEUi028-A can serve as a cell disease model in the understanding of HCM pathogenesis.
Identifiants
pubmed: 35772297
pii: S1873-5061(22)00197-0
doi: 10.1016/j.scr.2022.102848
pii:
doi:
Substances chimiques
Carrier Proteins
0
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102848Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.