Prolactin response to growth hormone stimulation tests.
GH stimulation tests
Growth hormone
Prolactin
Somatomammotrophic cells
Journal
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
ISSN: 1532-2238
Titre abrégé: Growth Horm IGF Res
Pays: Scotland
ID NLM: 9814320
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
01
05
2022
accepted:
16
06
2022
pubmed:
3
7
2022
medline:
22
7
2022
entrez:
2
7
2022
Statut:
ppublish
Résumé
Despite many similarities between the structure, receptors, proliferative and growth promoting actions, the relationship between Prolactin (PRL) and Growth Hormone (GH) in clinical conditions has received little attention. To determine the PRL response to GH stimulation tests. Prepubertal and early pubertal boys (n = 581) and girls (n = 502) with idiopathic, non-syndromatic short stature. Data was retrieved from the computerized records of the Endocrine Laboratory, Schneider Children's Medical Center. Peak GH and PRL levels during GH stimulation tests with glucagon (Gluc), Clonidine (Clon) and Clonidine with arginine (Clon+Arg), were compared. Both PRL and GH were determined by radioimmunoassay. Whereas Gluc stimulated both GH and PRL to similar levels, Clon alone or combined with Arg suppressed the PRL secretion (p < 0.0001). It is also evident that in both boys and girls Clon alone and Clon±Arg are superior to Gluc in GH stimulation. The higher GH levels during Clon+Arg than with Clon alone are attributed to the pubertal stage. This study provides further information on the Prolactin-Growth hormone relationship in children.
Sections du résumé
BACKGROUND
Despite many similarities between the structure, receptors, proliferative and growth promoting actions, the relationship between Prolactin (PRL) and Growth Hormone (GH) in clinical conditions has received little attention.
OBJECTIVE
To determine the PRL response to GH stimulation tests.
SUBJECTS
Prepubertal and early pubertal boys (n = 581) and girls (n = 502) with idiopathic, non-syndromatic short stature.
DESIGN
Data was retrieved from the computerized records of the Endocrine Laboratory, Schneider Children's Medical Center. Peak GH and PRL levels during GH stimulation tests with glucagon (Gluc), Clonidine (Clon) and Clonidine with arginine (Clon+Arg), were compared. Both PRL and GH were determined by radioimmunoassay.
RESULTS
Whereas Gluc stimulated both GH and PRL to similar levels, Clon alone or combined with Arg suppressed the PRL secretion (p < 0.0001). It is also evident that in both boys and girls Clon alone and Clon±Arg are superior to Gluc in GH stimulation. The higher GH levels during Clon+Arg than with Clon alone are attributed to the pubertal stage.
CONCLUSION
This study provides further information on the Prolactin-Growth hormone relationship in children.
Identifiants
pubmed: 35779406
pii: S1096-6374(22)00040-5
doi: 10.1016/j.ghir.2022.101483
pii:
doi:
Substances chimiques
Human Growth Hormone
12629-01-5
Prolactin
9002-62-4
Growth Hormone
9002-72-6
Growth Hormone-Releasing Hormone
9034-39-3
Arginine
94ZLA3W45F
Clonidine
MN3L5RMN02
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101483Informations de copyright
Copyright © 2022. Published by Elsevier Ltd.