ILC2s and Adipose Tissue Homeostasis: Progress to Date and the Road Ahead.
ILC2
adipose tissue
cytokines
innate lymphoid cells
intestine
metabolism
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
15
02
2022
accepted:
04
05
2022
entrez:
5
7
2022
pubmed:
6
7
2022
medline:
7
7
2022
Statut:
epublish
Résumé
Group 2 innate lymphoid cells (ILC2s) were initially identified as a new type of lymphocytes that produce vigorous amounts of type 2 cytokines in adipose tissue. Subsequent studies revealed that ILC2s are present not only in adipose tissue but also in various other tissues such as lung and skin. ILC2s are generally recognized as tissue-resident immune cells that regulate tissue homeostasis. ILC2s express receptors for various humoral factors and thus can change their functions or distribution depending on the environment and circumstances. In this review, we will outline our recent understanding of ILC2 biology and discuss future directions for ILC2 research, particularly in adipose tissue and metabolic homeostasis.
Identifiants
pubmed: 35784368
doi: 10.3389/fimmu.2022.876029
pmc: PMC9243262
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
876029Informations de copyright
Copyright © 2022 Misawa, Wagner and Koyasu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Cell Metab. 2015 Apr 7;21(4):543-57
pubmed: 25863247
Immunity. 2014 Sep 18;41(3):354-365
pubmed: 25238093
Nat Commun. 2022 Feb 2;13(1):624
pubmed: 35110546
Immunity. 2019 Oct 15;51(4):682-695.e6
pubmed: 31353223
Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11489-94
pubmed: 20534524
Immunol Rev. 2017 Jul;278(1):207-218
pubmed: 28658554
N Engl J Med. 2009 Apr 9;360(15):1509-17
pubmed: 19357406
Sci Immunol. 2019 May 3;4(35):
pubmed: 31053655
Diabetes. 2009 Jul;58(7):1526-31
pubmed: 19401428
Nature. 2013 Oct 10;502(7470):245-8
pubmed: 24037376
Immunology. 2018 Dec;155(4):407-417
pubmed: 30229891
Immunity. 2015 Jul 21;43(1):161-74
pubmed: 26092469
Nature. 2010 Apr 29;464(7293):1367-70
pubmed: 20200518
Physiol Rep. 2019 Mar;7(6):e14031
pubmed: 30873754
J Clin Invest. 2017 Sep 1;127(9):3300-3312
pubmed: 28758901
Expert Opin Ther Targets. 2015 Apr;19(4):527-38
pubmed: 25474374
J Exp Med. 2018 Jun 4;215(6):1609-1626
pubmed: 29728440
J Immunol. 2013 Dec 1;191(11):5349-53
pubmed: 24166975
Cell. 2018 Aug 23;174(5):1054-1066
pubmed: 30142344
Nat Immunol. 2018 May;19(5):464-474
pubmed: 29670241
Cell Metab. 2018 Jan 9;27(1):252-262.e3
pubmed: 29320705
J Endocrinol. 2016 Oct;231(1):35-48
pubmed: 27562191
J Exp Med. 2013 Mar 11;210(3):535-49
pubmed: 23420878
Cell Metab. 2017 Oct 3;26(4):686-692.e3
pubmed: 28918935
Immunol Rev. 2018 Nov;286(1):37-52
pubmed: 30294963
Cell. 2012 Jul 20;150(2):366-76
pubmed: 22796012
Cell Metab. 2021 Nov 2;33(11):2277-2287.e5
pubmed: 34473956
Sci Immunol. 2019 May 3;4(35):
pubmed: 31053654
Cell Rep. 2019 Jul 2;28(1):202-217.e7
pubmed: 31269440
J Exp Med. 2018 Jan 2;215(1):263-281
pubmed: 29222107
J Exp Med. 2021 Dec 6;218(12):
pubmed: 34709349
Nature. 2017 Sep 21;549(7672):351-356
pubmed: 28902842
J Exp Med. 2019 Sep 2;216(9):1999-2009
pubmed: 31248899
Nature. 2021 Sep;597(7876):410-414
pubmed: 34408322
Nature. 2017 Sep 14;549(7671):277-281
pubmed: 28869974
Science. 2018 Mar 2;359(6379):1056-1061
pubmed: 29496881
Nature. 2012 Jun 28;486(7404):549-53
pubmed: 22722857
Nature. 2010 Jan 28;463(7280):540-4
pubmed: 20023630
J Exp Med. 2014 Mar 10;211(3):563-77
pubmed: 24516120
Immunity. 2018 Jun 19;48(6):1195-1207.e6
pubmed: 29907525
Immunity. 2019 Oct 15;51(4):709-723.e6
pubmed: 31604686
Nature. 2015 Mar 12;519(7542):242-6
pubmed: 25533952
Front Immunol. 2020 Feb 06;11:116
pubmed: 32117267
Nat Commun. 2020 Jun 10;11(1):2922
pubmed: 32523103
Nat Immunol. 2016 Jan;17(1):76-86
pubmed: 26595888
Nature. 2017 Sep 14;549(7671):282-286
pubmed: 28869965
J Clin Invest. 2003 Dec;112(12):1796-808
pubmed: 14679176
Cell. 2015 Jan 15;160(1-2):74-87
pubmed: 25543153
Biochem Biophys Res Commun. 2016 Feb 19;470(4):930-5
pubmed: 26826380
Science. 2018 Jan 5;359(6371):114-119
pubmed: 29302015