Rational engineering of natural polyhydroxyalkanoates producing microorganisms for improved synthesis and recovery.
Journal
Microbial biotechnology
ISSN: 1751-7915
Titre abrégé: Microb Biotechnol
Pays: United States
ID NLM: 101316335
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
07
01
2022
accepted:
14
06
2022
pubmed:
7
7
2022
medline:
26
1
2023
entrez:
6
7
2022
Statut:
ppublish
Résumé
Microbial production of biopolymers derived from renewable substrates and waste streams reduces our heavy reliance on petrochemical plastics. One of the most important biodegradable polymers is the family of polyhydroxyalkanoates (PHAs), naturally occurring intracellular polyoxoesters produced for decades by bacterial fermentation of sugars and fatty acids at the industrial scale. Despite the advances, PHA production still suffers from heavy costs associated with carbon substrates and downstream processing to recover the intracellular product, thus restricting market positioning. In recent years, model-aided metabolic engineering and novel synthetic biology approaches have spurred our understanding of carbon flux partitioning through competing pathways and cellular resource allocation during PHA synthesis, enabling the rational design of superior biopolymer producers and programmable cellular lytic systems. This review describes these attempts to rationally engineering the cellular operation of several microbes to elevate PHA production on specific substrates and waste products. We also delve into genome reduction, morphology, and redox cofactor engineering to boost PHA biosynthesis. Besides, we critically evaluate engineered bacterial strains in various fermentation modes in terms of PHA productivity and the period required for product recovery.
Identifiants
pubmed: 35792877
doi: 10.1111/1751-7915.14109
pmc: PMC9871526
doi:
Substances chimiques
Polyhydroxyalkanoates
0
Biopolymers
0
Plastics
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
262-285Subventions
Organisme : ANID
ID : Fondecyt Regular Nº 1210332
Organisme : ANID-PIA-Anillo
ID : INACH ACT192057
Organisme : ANID-PIA-Anillo
ID : INACH RG_17_19
Organisme : Junta de Andalucía, Consejería de transformación económica, industria, conocimiento y universidades
ID : EMERGIA20_00048
Informations de copyright
© 2022 The Authors. Microbial Biotechnology published by Society for Applied Microbiology and John Wiley & Sons Ltd.
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