Neurons contribute to pathology in a mouse model of Krabbe disease in a cell-autonomous manner.
Journal
PLoS biology
ISSN: 1545-7885
Titre abrégé: PLoS Biol
Pays: United States
ID NLM: 101183755
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
entrez:
6
7
2022
pubmed:
7
7
2022
medline:
9
7
2022
Statut:
epublish
Résumé
In this issue of PLOS Biology, Kreher and colleagues show in a mouse model that in vivo, neurons and not only myelinating glia are primary effectors of disease progression in Krabbe disease. The neuron-specific model generated allows the unprecedented capacity to investigate the neuronal autonomous component of this disorder.
Identifiants
pubmed: 35793314
doi: 10.1371/journal.pbio.3001706
pii: PBIOLOGY-D-22-01121
pmc: PMC9258894
doi:
Substances chimiques
Galactosylceramidase
EC 3.2.1.46
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
e3001706Commentaires et corrections
Type : CommentOn
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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